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Drugs for Treatment of Neurological and Psychological Conditions
Published in Richard J. Sundberg, The Chemical Century, 2017
Antipsychotic drugs are those used in the more severe types of mental illness, including schizophrenia, manic-depressive bipolar disorder, psychotic depression, and some types of dementia. The term psychotic implies disordered thoughts and behavior and dissociation from reality, such as delusions and hallucinations.
Uncertainty, emergence and adaptation: A complex adaptive systems approach to quality improvement
Published in Quality Management Journal, 2023
William Wilson, Scott McLachlan, Kudakwashe Dube, Kathleen Potter, Nihal Jayamaha
A significant proportion of people living in residential aged care are exposed to antipsychotic medication, with approximately one-third of residents receiving a medicine in this class at some point during their admission. Antipsychotic use is associated with significant adverse effects and an increased risk of premature death, especially for people with dementia. Studies of antipsychotic deprescribing in people living in residential care have produced mixed results (Van Leeuwen et al. 2018). Some trials have successfully withdrawn antipsychotics in participants without apparent adverse effect, but other trials have either failed to reduce antipsychotic use successfully, failed to show any benefit associated with cessation, or reported an increase in adverse outcomes associated with deprescribing (Van Leeuwen et al. 2018).
Synthesis, crystal structure, hirshfeld surface analysis, molecular docking and molecular dynamics studies of novel olanzapinium 2,5-dihydroxybenzoate as potential and active antipsychotic compound
Published in Journal of Experimental Nanoscience, 2022
V. Natchimuthu, Mohnad Abdalla, Manasi Yadav, Ishita Chopra, Anushka Bhrdwaj, Khushboo Sharma, S. Ravi, Krishnan Ravikumar, Khalid J. Alzahrani, Tajamul Hussain, Anuraj Nayarisseri
Antipsychotic medication, also known as neuroleptics is a class of psychotropics primarily manoeuvred for short- or long-term treatments of psychotic disorders (bipolar depression, delusions, paranoia, schizophrenia, etc.). Studies have revealed that Olanzapine, a novel atypical antipsychotic drug elicits a high response with low dosage on the patients suffering from psychotic ailments. It consists of a thieno-benzodiazepinyl structure and exhibits a similar in vitro binding profile with an atypical anti-psychotic agent; an FDA-approved drug, Clozapine [1,2]. According to the Biopharmaceutical Classification System (BCS), Olanzapine belongs to class II (low solubility, high permeability) cadre, and is highly effective in positive, negative, and cognitive symptoms for acute and relapsing schizophrenics. This drug is marketed under the trademark, Zyprexa by Eli Lilly and Company [3,4].
Precautions & Possible Therapeutic Approaches of Health Hazards of Astronauts in Microgravity
Published in The International Journal of Aerospace Psychology, 2021
Nikita Pal, Shambaditya Goswami, Rajveer Singh, Tejpal Yadav, Ravindra Pal Singh
Behavioral and psychiatric conditions as signs and symptoms of anxiety, depression, asthenia, psychosomatic reactions, salutogenic responses, and so on, are observed in astronauts during space flight. Donepezil, Rivastigmine, and other antidepressants, anti-anxiety medications, antipsychotics can be prescribed to treat cognitive behavior or Alzheimer’s-like conditions. Stress Management and Resilience Training for Optimal Performance (SMART-OP) is specially designed for astronauts to detect, prevent, and manage stress during space exploration. Besides these techniques, according to Eastern spiritual practices, especially Buddhism, mindfulness-based stress reduction or meditation practice might be a good self-management practice for them. Mindfulness meditation is an introspective psychological mind state that reduces mind wandering and focuses on increasing awareness with clear comprehension (Bishop et al., 2004; Healthline, 2019; NASA, 2016).