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Recent Advances of Alginate Biomaterials in Tissue Engineering
Published in Shakeel Ahmed, Aisverya Soundararajan, Marine Polysaccharides, 2018
Jayachandran Venkatesan, Sukumaran Anil, Sandeep Kumar Singh, Se-Kwon Kim
Dental bone tissue engineering is similar to bone tissue engineering, and the utilisation of alginate in dental tissue regeneration is increasing. Recently, Davillard et al. (2017) developed a collagen–alginate–stem cell composite scaffold for endontics regeneration. MSCs were differentiated and formed an osseous ECM [108]. Peri-implantitis is one of the common inflammatory problems in dental implantology. Silver lactate containing an RGD-coupled alginate hydrogel scaffold with stem cells was developed. The developed scaffold showed good antimicrobial properties against Aggregatibacter actinomycetemcomitans in a dose-dependent manner. Osteogenic mineralisation of stem cells in the scaffold was measured by mineral matrix deposition [109].
Next-generation DNA sequencing of oral microbes at the Sir John Walsh Research Institute: technologies, tools and achievements
Published in Journal of the Royal Society of New Zealand, 2020
Nicholas C. K. Heng, Jo-Ann L. Stanton
For decades, students of the oral health-related professions across the world have been taught that the mutans streptococci (i.e. Streptococcus mutans and related species) cause dental caries and that the development of periodontal disease (periodontitis) is mainly attributed to the Gram-negative bacterium, Porphyromonas gingivalis (Socransky and Haffajee 2005; Paster et al. 2006). As these bacteria, especially the streptococci, are readily cultured in the laboratory and also amenable to genetic modification, the virulence factors of these organisms have been, and still are being, widely-studied. New species, e.g. Scardovia wiggsiae, have since been identified in dental caries lesions (Downes et al. 2011). Similarly, the periodontal pathogens have been categorised into complexes by Socransky (reviewed by Socransky and Haffajee 2005) with P. gingivalis being in the Red complex (high pathogenicity/association) and organisms exhibiting lower pathogenicity, e.g. Aggregatibacter actinomycetemcomitans and Prevotella spp. in the Orange and Yellow complexes.