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Polymers-Based Devices for Dermal and Transdermal Delivery
Published in Severian Dumitriu, Valentin Popa, Polymeric Biomaterials, 2020
Donatella Paolino, Margherita Vono, Felisa Cilurzo
More recently, hyaluronic acid has been investigated as a vehicle able to localize the drug in the epidermis, and a formulation, marketed as Solaraze®, was already approved in the United States, Canada, and most European countries for the topical treatment of actinic keratoses (Jarvis and Figgitt 2003). In this application hyaluronic acid, as largely demonstrated (Brown et al. 1995), enhances significantly the partitioning of diclofenac into human skin and its retention and localization in the epidermis with respect to other pharmaceutical formulations (aqueous solution, or other gelling agents as polysaccharides [Brown and Martin 2001]).
ADTBO: Aquila driving training-based optimization with deep learning for skin cancer detection
Published in The Imaging Science Journal, 2023
Vadamodula Prasad, Emil Selvan G. S. R., Ramkumar M. P.
The repeated identification of lesions from dermoscopy image overcomes numerous complications owing to the complex lesion features and its shape. Melanoma, Benign Keratosis, Actinic Keratosis, Basal Cell Carcinoma, Melanocytic Nevus, Dermatofibroma and Vascular are the eight different types of skin cancer in which Melanoma is the harmful type of skin cancer causing severe damage to the skin and spreading to other areas of the body. Timely detection of skin cancer has been shown in studies to significantly reduce the death rate. Detecting skin cancer at an early stage is a tedious task for dermatologists, which motivates researchers to design a simplified and automatic skin cancer detector to detect skin cancer at an early stage, which can greatly assist dermatologists [4]. Melanoma is most commonly found on the behind of a person's lower limb and also it can occur anywhere on the human body. Moreover, individuals’ risk aspects for skin cancer illness have to be condensed by sensing it at an early stage. The detection of skin cancer in its primary stages can effect in a significant diminution in death. As a result, identifying and classifying this disease in its early stages is critical [3].
WEL-ODKC: weighted extreme learning optimal diagonal-kernels convolution model for accurate classification of skin lesions
Published in The Imaging Science Journal, 2023
V. Auxilia Osvin Nancy, P. Prabhavathy, Meenakshi S. Arya
This dataset was mainly created by the Federal University of Espírito Santo (UFES-Brazil) for a non-profit programme that affords free treatment to non-privileged individuals who cannot afford private hospital treatment. This dataset comprises a total of 2298 samples belonging to six different types of skin cancers. Every image has a total of 22 clinical features associated with it. The six different classes present in the dataset are actinic keratosis, squamous cell carcinoma, Seborrheic Keratosis, Basal Cell Carcinoma, nevus, and melanoma. The image size of the dataset varies since they are taken using different smartphone cameras. For classifications, 9 diseases were obtained from the two datasets, and the dataset distribution is listed in Table 1.
Recent advances in nanotechnology based combination drug therapy for skin cancer
Published in Journal of Biomaterials Science, Polymer Edition, 2022
Shweta Kumari, Prabhat Kumar Choudhary, Rahul Shukla, Amirhossein Sahebkar, Prashant Kesharwani
Transfersomes are an artificial vesicular carrier which is designed to show the features of a cell vesicle or cells engaged in exocytosis. These transferosomes are suitable for controlled and potentially targeted delivery of drugs [55]. These are special types of liposomes, composed of phosphatidylcholine and an edge activator. Transferosomes are biodegradable, biocompatible, have better penetration and better solubilities in both hydrophilic and lipophilic structures. These have advantage of having phospholipids vesicles as transdermal drug delivery system also. Transfersomes can distribute higher quantities of both larger and smaller therapeutic agents through and into the skin. The transfersomes usage in cancer patients may be utilized in the treatment of actinic keratosis, basal cell carcinoma, squamous cell carcinoma, melanoma and kaposi’s sarcoma. The transfersomes may be a good carrier for the delivery and distribution of the drugs into the skin layers and so, are useful in the skin carcinoma treatment [56].