5-HT1B

5-HT1B

The stress-response

Published in Herman Staudenmayer, Environmental Illness, 2018

Medications that are hypothesized to inhibit the reuptake of 5-HT in the neural synapses — selective serotonin reuptake inhibitors (SSRIs), e.g., Prozac (fluoxetine hydrochloride), Zoloft (sertraline hydrochloride), and Paxil (paroxetine hydrochloride) — have proven effective in amelioration of symptoms of depression and anxiety. Obsessive thoughts and compulsive behaviors in particular are reduced by SSRIs (Jenike et al., 1990), an effect consistent with reduced hyperarousal and decreased hypervigilance.

Regio- and stereo-selective ring expansion of keto-aziridines to the corresponding thiomorpholines

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Journal Information

Published in Journal of Sulfur Chemistry, 2021

Fatemeh Khodadadi, Heshmat Allah Samimi, Jalal Albadi, Ahmadreza Momeni

The earliest example of the synthesis of a 3-oxothiomporpholine and thiomorpholines were described by Karrer and Bestian respectively [1]. The 3-thiomorpholinone skeleton plays a significant role for biological activity, such as enhancement of brain noradrenaline and dopamine turnover [2], hypnotic activity [3], and antagonism on 5-HT1b [4], and EP4 receptors [5]. Thiomorpholines have also been found to exhibit antihypertensive [6] and antimycobacterial activities [7] as well as in the 1,4-benzothiazine calcium antagonist Semotiadil [8–10], pyrimidothiazine derivatives [11]. In addition, chiral thiomorpholines have been used as a chiral catalyst for sulfur ylide mediated symmetric epoxidation of aldehydes [12].

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The stress-response

Regio- and stereo-selective ring expansion of keto-aziridines to the corresponding thiomorpholines