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Nickel Allergic Hypersensitivity: Prevalence and Incidence by Country, Gender, Age, and Occupation
Published in Jurij J. Hostýnek, Howard I. Maibach, Nickel and the Skin, 2019
Jurij J. Hostýnek, Katherine E. Reagan, Howard I. Maibach
Based on a retrospective cohort study conducted by interview among a stratified sample of the Danish female population, incidence density of NAH was found to have doubled in all age groups from 1948 to 1973. Out of a total population sample of 1976, 286 recalled a history of allergy to suspenders, metal buttons, fasteners, or costume jewelry (14.2%). This was taken as an indication of the sources of nickel allergy in this study. Based on recall, the highest incidence in the onset of nickel allergy appeared to occur in the age bracket of 10 to 19 years (114; 40%); the highest prevalence of nickel allergy appeared to occur in the age brackets of 20 to 29 and 40 to 49 years at 19%.
The science of nail polish, nail polish remover, and nail moisturizers
Published in Archana Singal, Shekhar Neema, Piyush Kumar, Nail Disorders, 2019
Other reported adverse effects include onychodystrophy, onycholysis, and paronychia. Sometimes nail varnish, used as a barrier against nickel allergy, can itself lead to its sensitization.11 An uncommon but potentially serious adverse effect has been reported with dibutyl phthalate (used as a plasticizer) including decreased sperm mobility and viability15 and endocrine disruption leading to altered development of fetal testes.16
Continuous subcutaneous infusion
Published in Cooper Jo, Burnard Philip, Stepping into Palliative Care 2, 2017
Occasionally, a patient develops a local skin reaction at the site of a continuous subcutaneous infusion. There are several causes, which include drugs and nickel allergy. The risk of developing a site reaction can be reduced by:
Current status of biopsy markers for the breast in clinical settings
Published in Expert Review of Medical Devices, 2022
Elian A. Martin, Neeraj Chauhan, Vijian Dhevan, Elias George, Partha Laskar, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
There are no promising clinical reports indicating severe allergies associated with nickel breast markers; however, it is advised patients not use nickel if they are known to have nickel allergy. If this occurs after implantation, immediate removal of the marker is recommended utilizing vacuum-assisted devices. Titanium or nonmetal breast markers can be utilized in such conditions. Currently, there are no recommended guidelines regarding the management of the migration of breast markers. Marker misplacement and migration may happen due to immediate compression and de-compression cycles of the breast and time gap between biopsy and post-biopsy mammogram. On some occasions because of minute fragments of metal near surgical ligature, it can be visualized as calcification. There is no specific clinical study examined so far to assess the comparison of all types of markers and from different companies. Altogether, breast marker placement offsets the drawbacks. In clinical settings, breast markers enable visualization across multiple breast imaging modalities, pin-point detection of placement and localization of abnormalities in breast tissue, follow-up treatment outcome and follow-up care of patients.
Reference intervals for trace elements in the general Danish population and their dependence on serum proteins
Published in Scandinavian Journal of Clinical and Laboratory Investigation, 2021
Louise H. Jørgensen, Camilla H. Sindahl, Lise Pedersen, Flemming Nielsen, Tina K. Jensen, Janne Tolstrup, Ola Ekholm, Philippe Grandjean
In our data set, nickel in serum appears to have increased dramatically since 1992 from a median of 3.4 nmol/L to 10.73 nmol/L [4] (Table 2). This is possibly a controversial finding since nickel is a potent allergen and elevations in serum-nickel are associated with worsening of dermatitis symptoms in nickel-allergic subjects [32], even though having nickel allergy is not necessarily associated with elevated serum-nickel concentrations as such [33]. Interestingly, results of nickel concentrations in serum have varied much [34], and our median concentration is in line with a recent study from France, where a mean of 0.63 µg/L is reported. However, the routinely used matrix for nickel determination is urine, and thus the serum concentrations may represent a different marker that may not adequately reflect the bioavailable nickel load in the body. Whether the apparently increased nickel concentrations found in this study indeed represent an unstable and time-dependent picture or in fact is due to increased environmental, work-related or dietary changes is unknown [35]. However, it could also be a matter of different analytical techniques, since methods have improved with the implementation of mass spectrometry-based methods as used in this study. While we use nickel cones for our ICP-MS analyses, blanks consisting of dilution buffer show no sign of contamination from the cones, thus arguing against internal contamination as a cause of elevated values.
Metal Nanoparticles in Infection and Immunity
Published in Immunological Investigations, 2020
An additional factor that must be taken into account in assessing toxicity of metal nanoparticles is that the nanoparticles do not necessarily remain at the site of administration (Falconer et al. 2018; Falconer and Grainger 2018; Vila et al. 2018). Instead, particles injected intramuscularly in an animal may traffic to the regional lymph nodes. As another example, nanoparticles administered by inhalation do not remain in the lungs and airways, but may translocate to other organs, including mediastinal lymph nodes, bloodstream, and kidneys (Choi et al. 2010). This requires a careful assessment of possible action of metal nanoparticles in organs and tissues distant from the site of administration. In addition to direct toxicity, nickel nanoparticles triggered nickel allergy in mice, and this was potentiated by lipopolysaccharide (LPS)(Hirai et al. 2016). Nickel allergy is the most common type of metal allergy in humans, and is important because nickel alloys are used in buttons and snaps on clothing, in eyeglass frames, and in jewelry. Nanoparticles appear especially prone to triggering inflammatory reactions in the lung, including pulmonary fibrosis in animals such as rats (Cho et al. 2011; Lai et al. 2018; Thompson et al. 2014).