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Injuries Due to Burns and Cold
Published in Ian Greaves, Keith Porter, Jeff Garner, Trauma Care Manual, 2021
Ian Greaves, Keith Porter, Jeff Garner
Artificial skin dressings fall into two broad categories: temporary skin substitutes and dermal regeneration. Temporary skin substitutes, such as Biobrane™ or Transcyte™, reduce pain scores, length of hospital stay and time to healing.22, 23 The frequency of dressing changes is also greatly reduced with the use of these dressings. However, they are suitable only for superficial to mid-dermal injuries. Biobrane™ is also used as a temporary wound dressing while the skin graft donor site heals, to allow re-harvest, or while cultured epithelial cells are prepared.24
Introduction to Bio-Implants
Published in S Santhosh Kumar, Somashekhar S. Hiremath, Role of Surface Modification on Bacterial Adhesion of Bio-Implant Materials, 2020
S Santhosh Kumar, Somashekhar S. Hiremath
Bio-implants are prostheses devices used to regularize physiological functions. They are made up of biosynthetic materials like collagen, and tissue-engineered products like artificial skin or tissues. Most bio-engineered products like cardiac pacemakers and orthopaedic artificial implants are also covered under bio-implants because they are implanted entirely in the patient’s body. Bio-implants are mostly classified at a broader level such as orthopaedic, cardiovascular, dental, ophthalmic, and neurostimulation implants; these are listed in Table 1.1.
Human Skin Xenografts to Athymic Rodents as a System to Study Toxins Delivered to or Through Skin
Published in Rhoda G. M. Wang, James B. Knaak, Howard I. Maibach, Health Risk Assessment, 2017
Gerald G. Krueger, Lynn K. Pershing
It is intuitive that a very significant advance in clinical medicine would come with the ability to generate an artificial skin in vitro, also referred to as a skin-equivalent. This skin could be transplanted onto human subjects to replace burned skin, cover skin ulcers, or possibly even to correct a disorder inherent to skin. Such skin would, ideally, be non-immunogenic, functional, and persistent or slowly undergo resorption in the transplanted state. Current technology dictates that skin equivalents have an artificial dermis that can be impregnated with fibroblasts and covered with keratinocytes or an artificial barrier. The cellular constituents in such a skin-equivalent can be either allogeneic or, if they can be generated from the patient needing the artificial skin, autologous. In each scenario, there are questions as to the function, survival time, etc. of the artificial skin in the grafted state. Being able to observe such grafts in the in vivo state of the nude rat or mouse has and will answer at least some of the preclinical questions inherent to this technology.24-27
Vascularization of Lando® dermal scaffold in an acute full-thickness skin-defect porcine model
Published in Journal of Plastic Surgery and Hand Surgery, 2018
Xuewen Qiu, Jiahan Wang, Guifang Wang, Huangdin Wen
Skin defects are very common and caused by various acute and chronic factors such as mechanical damage, burns, body surface tumor resection and chronic ulcers [1,2]. Skin graft is often the main form of treatment. Because the sources and applications of autologous or allogeneic skin are limited in some cases, the search for an ideal skin substitute is ongoing. While the dermis is known to play an important role in skin grafts, tissue engineering skin with the epidermis and dermis is not ideal; therefore, there are still considerable clinical needs for dermal substitutes (such as Integra artificial skin). The clinical application of dermal substitutes has been greatly expanded and the clinical curative effect was found to be satisfactory [3–6].
Cell-Biomaterial constructs for wound healing and skin regeneration
Published in Drug Metabolism Reviews, 2022
Ingrid Safina, Luke T. Childress, Srinivas R. Myneni, Kieng Bao Vang, Alexandru S. Biris
Commercial skin substitutes are divided into three categories: epidermal, dermal, and dermo-epidermal grafts. Skin grafts generally contain two sections in order to achieve proper healing and integration to the host. The outer section acts as a scaffold and is biodegradable; it supports the inner section, which allows for vascularization, growth factors, and cellular adhesion (Briquez et al. 2015; Castellano et al. 2018). There are many artificial skin substitutes available on the market; this review will cover some of the more commonly used products.
Evaluating and reducing xerosis in competitive swimmers: an in vitro study and randomized controlled clinical trial
Published in Journal of Dermatological Treatment, 2021
Kimball Sheehan, Darrah Sheehan, Mary Margaret Noland
Using an in vitro model, we tested the ability of five different agents to protect an artificial ‘skin’. The control group demonstrated 74% and 80% reductions in skin thickness and weight, respectively (Table 1(a,b)). Moisture Barrier #1 best preserved the skin’s thickness and weight after 1 week of in vitro testing; preservation of thickness and weight provided by Moisture Barrier #1 was statistically superior to controls (Table 1(a,b)).