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A Perspective of Ultrasound-Related Micro/Nano Cancer Therapy
Published in Hala Gali-Muhtasib, Racha Chouaib, Nanoparticle Drug Delivery Systems for Cancer Treatment, 2020
Tingting Zheng, Yun Chen, Jiao Peng, Yu Shi, Jun Zhang, Haitao Xiao, Xiangmei Chen, Yongcan Huang, Tao Pei, Zhuxia Zhang, Xue Zhang, Xiaohe Bai, Li Liu, Jinrui Wang
Detection and propagation of high-frequency (>20 kHz) acoustic wave in tissue is quite a mature technique in clinical diagnosis [50]. Ultrasound impedance could distinguish among different tissues. The echo received could be processed to show 2D and/or 3D tissue images [51]. Besides, damped acoustic energy that accumulates in tissue could cause fluid streaming, tissue motion and heat in situ. For therapeutic adhibition, heating enables ultrasound applications in thermal ablation and/or local physiotherapy; while fluid steaming is related to transdermal sonophoresis [52]. One of the most typical ultrasound therapy effects is cavitation. Once there is a rapid decrease of local pressure, vaporization and/or evolution of dissolved gases show up. However, when there is an increase in local pressure mediated by ultrasound, bubbles form and then collapse violently, yielding significant damage at local and surrounding tissues or structures [53]. Moreover, pre-existing bubbles can be applied in combination with low amplitude ultrasound, leading to prominent mechanical effects.
Head and neck
Published in Tor Wo Chiu, Stone’s Plastic Surgery Facts, 2018
In a randomised placebo-controlled trial, a group of 10 infants with congenital muscular torticollis had physiotherapy/exercises along with ultrasound therapy, whilst a second group had additional microcurrent treatment. Microcurrent therapy consists of a probe placed on the skin delivering small amounts of electricity to the tissues, supposedly increasing blood flow reducing spasm. Ultrasound therapy generates deep heat supposedly decreasing inflammation. The latter group had significantly better passive range of motion, as well as a shorter treatment time (2.6 months vs. 6.3 months).
Metabolic Therapies for Muscle Injury
Published in Kohlstadt Ingrid, Cintron Kenneth, Metabolic Therapies in Orthopedics, Second Edition, 2018
Ana V. Cintrón, Kenneth Cintron
Ultrasound has both thermal and non-thermal effects, by which the proposed treatment for wounds and inflammation is based on the belief that either its heat production (by increasing blood flow and metabolic or enzymatic activity) or non-thermal effects (by changing cell wall permeability) accelerate healing [27]. Even so, there are few studies specifically evaluating its use in muscle strains. A systematic review by Van der Windt et al. [28] from well-designed trials evaluating ultrasound therapy concluded that there is little evidence to show efficacy in the treatment of musculoskeletal disorders. Similarly, a literature review by Shanks et al. [29] from studies dating from 1975 to 2009 found that there is currently no high-quality evidence available to suggest that therapeutic ultrasound is effective for musculoskeletal conditions of the lower limb.
Low-intensity ultrasound promotes uterine involution after cesarean section: the first multicenter, randomized, controlled clinical trial
Published in International Journal of Hyperthermia, 2022
Yi Qin, Xiaobo Zhao, Xiaojing Dong, Juntao Liu, Longqiong Wang, Xiaohua Wu, Bin Peng, Chengzhi Li
Women suffer different types of pain and discomfort after delivery, including incision pain after cesarean section and uterine involution pain [41]. Acute and chronic pain caused by severe tissue trauma after delivery may increase the risk of postpartum depression and affect women to return to normal activities and care for their babies [42]. The incidence of chronic pain ranges from 1% to 18% [43], many scholars are paying more attention to the postpartum pain of parturients [44,45]. Ultrasound therapy can downregulate inflammatory mediators to promote extracellular matrix production [46], and LIUS shows significant effects on cell proliferation and collagen deposition [47]. Xin et al. reported that soft tissue regeneration can be accelerated by promoting cell proliferation in the disease [48]. Jia et al. also confirmed that ultrasound in the treatment of knee osteoarthritis (KOA) has been proved to be a safe and effective treatment, which can relieve the pain of patients with KOA [49]. The effect of reducing pain is remarkable when treating soft tissue injuries by ultrasound therapy. In this study, the VAS score of the LIUS group shows a sharper decline than that of the control group, with a significant difference (p < 0.0001). We believe that ultrasound has the same ability to provide postpartum analgesia for the smooth muscle of the uterus, as a type of soft tissue.
Comparison of thermal ablative methods and myomectomy for the treatment of fibroids: a systematic review and meta-analysis
Published in International Journal of Hyperthermia, 2021
Deku Liang, Juan Li, DanDan Liu, Hu Zhao, Yonghong Lin
The modalities of thermal ablative treatment for uterine fibroids vary in clinical practice. The result of therapy after percutaneous magnetic resonance (MR) image-guided laser ablation was found to be comparable to hysterectomy for the management of menorrhagia caused by fibroids [39]. Berman et al. [40] reported a significant improvement in symptoms by using radiofrequency volumetric thermal ablation in patients with fibroids. Zhang et al. [41] found that fibroids could shrink by 93.1% without complications and fever, after percutaneous microwave thermal ablation. The safety and efficacy of focused ultrasound guided by ultrasound or MRI have been confirmed for the treatment of fibroids [42,43]. In the relevant 13 studies, we included, focused ultrasound therapy was used in 10 trials, and radiofrequency therapy was used in the rest.
Six month nonunion tibial diaphysis osteotomy treated with conventional pulsed therapeutic ultrasound: a case report
Published in Physiotherapy Theory and Practice, 2022
Carlos E. Pinfildi, Ricardo S. Guerra, Mariana C. Ventura
The literature has shown that therapeutic ultrasound has been widely used to treat established nonunion fractures, with low-intensity pulsed ultrasound (LIPUS) being the most studied ultrasound modality (Leighton et al., 2017). The LIPUS is characterized by a pulsed ultrasound device with a frequency of 1.5 MHz, a burst frequency of 1 KHz, a duty cycle of 20% (200 µs burst width), and an intensity of 30 mW/cm2 (Watanabe et al., 2010). Although LIPUS is a particular device developed to treat fractures, it is not widely available, thus limiting its practical application. In contrast, conventional ultrasound therapy is widely used in contemporary physiotherapy practice (Warden, 2003).