Infracyanine green

Infracyanine green (IFCG) is a standard dye used for staining the internal limiting membrane (ILM) in medical procedures. It is often used in double staining techniques alongside trypan blue for staining the epiretinal membrane (ERM). Indocyanine green (ICG) is another standard dye used for ILM staining, and IFCG is a similar dye that can also be used for this purpose.From: Vitreoretinal Surgical Techniques [2019], Advances in the tools and techniques of vitreoretinal surgery [2020]

Indocyanine green and trypan blue in vitreoretinal surgery

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Published in A Peyman MD Gholam, A Meffert MD Stephen, D Conway MD FACS Mandi, Chiasson Trisha, Vitreoretinal Surgical Techniques, 2019

Ron Afshari Adelman

Adequate visualization is critical in vitreoretinal surgery. Using dyes may enhance visualization and help the removal of transparent or semitransparent tissues, including epiretinal membranes (ERMs), the posterior hyaloid, and the internal limiting membrane (ILM). In recent years, indocyanine green (ICG), infracyanine green, and trypan blue have been utilized frequently in vitreoretinal surgery. This chapter discusses the techniques, advantages, disadvantages, and toxicity of ICG and trypan blue in ocular surgery.

Advances in the tools and techniques of vitreoretinal surgery

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Published in Expert Review of Ophthalmology, 2020

Ashish Markan, Aman Kumar, Jayesh Vira, Vishali Gupta, Aniruddha Agarwal

Indocyanine green (ICG) and infracyanine green are standard dyes for staining of internal limiting membrane [49]. These dyes possess strong affinity for collagen type 4 and laminin, which are important components of internal limiting membrane. The problem with ICG is that it is toxic to retinal photoreceptors and retinal pigment epithelium. It is safe to use ICG in concentration of 0.05% and osmolarity of less than 290mOsm. The toxicity of ICG is mainly attributed to iodine, which acts as a solvent for the dye. ICG also causes phototoxic damage to the retinal cells. Infracyanine green is relatively less toxic because it does not contain iodine.

Infracyanine green

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Indocyanine green and trypan blue in vitreoretinal surgery

Advances in the tools and techniques of vitreoretinal surgery