China
Africa
Explore chapters and articles related to this topic
Multicentre Studies
Published in Michael Ljungberg, Handbook of Nuclear Medicine and Molecular Imaging for Physicists, 2022
Terez Sera, Ronald Boellaard, Andres Kaalep, Michael Ljungberg
For cases 1 and 3, multiple metastases were inserted (seven for case 1; three for case 3). For case 1, some metastases were clearly visible, whereas others were smaller and therefore exhibited less contrast (Figure 27.7). For case 2, an increased uptake in a degenerative manner was observed in the vertebral column located between the vertebrae. The aim of cases 4 and 5 was to demonstrate the ease of finding the metastases when SPECT was used in combination with the planar images. In case 4, an uptake occurred in the pelvis, which was partly obscured by the bladder. Case 5 involved two removals in the lumbar spine that appeared significantly better on the SPECT than on the planar images. In 2017, a new survey regarding bone scintigraphy was initiated, and 10 simulated skeletal scintigraphs were included to detect and outline increased activity uptake.
Radionuclide Bone Scintigraphy
Published in Michael Ljungberg, Handbook of Nuclear Medicine and Molecular Imaging for Physicists, 2022
Kanhaiyalal Agrawal, Gopinath Gnanasegaran
Radionuclide bone scintigraphy is one of the most common Nuclear Medicine investigations. There have been significant advances in both the instrumentation and in radiopharmaceuticals. However, conventional bone scan remains to be an extremely valuable diagnostic test in several benign and malignant bone diseases.
McCune−Albright Syndrome
Published in Dongyou Liu, Handbook of Tumor Syndromes, 2020
Bone scan (bone scintigraphy) is useful for determining the extent of bone disease. A harmless radioactive dye is injected into the affected bone and a special camera is used to track the dye as it travels through bone.
Classification and management strategies for paediatric chronic nonbacterial osteomyelitis and chronic recurrent multifocal osteomyelitis
Published in Expert Review of Clinical Immunology, 2023
Shabnam Singhal, Caren Landes, Rajeev Shukla, Liza J McCann, Christian M Hedrich
Imaging of bone lesions, their distribution, and complications are among the most important tools to diagnose and monitor CNO/CRMO. Examples of pathological changes on imaging can be seen in Figure 5 and are summarized in Table 3. Whole-body (WB)-MRI has become the gold-standard for both diagnosis and monitoring of treatment response. Bone scintigraphy has been superseded by MRI but may be considered as an alternative where WB-MRI or serial MRI imaging is unavailable or contraindicated for safety reasons. MRI is preferred because it does not involve ionizing radiation, allows assessment of bone marrow and soft tissues and has greater sensitivity at detecting the overall number of lesions compared to x-rays and bone scintigraphy [10,79,80]. The metaphyses show physiologically increased uptake on bone scintigraphy making identification of pathology at these sites very difficult and MRI has been shown to be superior in detecting metaphyseal lesions [79–81].
Prevalence of cardiac amyloidosis among elderly patients with systolic heart failure or conduction disorders
Published in Amyloid, 2019
Ángela López-Sainz, F. Javier de Haro-del Moral, Fernando Dominguez, Alejandra Restrepo-Cordoba, Almudena Amor-Salamanca, Aitor Hernandez-Hernandez, Luis Ruiz-Guerrero, Isabel Krsnik, Marta Cobo-Marcos, Victor Castro, Jorge Toquero-Ramos, Enrique Lara-Pezzi, Ignacio Fernandez-Lozano, Luis Alonso-Pulpon, Esther González-López, Pablo Garcia-Pavia
Our study describes a 2% (95%CI: 0–4%) prevalence of ATTRwt amyloidosis in elderly patients with advanced conduction disorders requiring pacemaker implantation (Figure 3). Although, this prevalence could be judged as small and not sufficiently relevant to justify a systematic screening effort, we would highlight that bone scintigraphy is an inexpensive, widely available and non-invasive test, and that the ECG, echocardiographic and clinical characteristics of the two patients identified would not have been enough to establish a diagnosis of ATTRwt (mild and non-specific phenotype). Moreover, several new pharmacological agents are currently under development to treat ATTR cardiomyopathy and some of them have already shown positive results and will be available soon [25]. As in other infiltrative diseases, prompt recognition of the disorder and early initiation of therapy has been associated with better outcomes. Accordingly, it is of the utmost importance to raise a diagnosis of ATTR cardiomyopathy as early as possible. In this regard, several clinical, electrocardiographic and echocardiographic signs including the presence of carpal tunnel syndrome, spinal lumbar stenosis, ruptured biceps tendon, pseudo-infarct ECG pattern, pericardial effusion or a decreased ECG voltage/echocardiographic mass ratio, have been described to facilitate cardiac amyloid diagnosis [11,26,27]. In our opinion, an unexplained conduction problem should be added to this red-flag list and cardiac amyloidosis, particularly ATTRwt amyloidosis, should always be ruled out in elderly patients with unexplained AVB.
New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions
Published in Expert Review of Clinical Immunology, 2019
Concetta Schiano, Andrea Soricelli, Filomena De Nigris, Claudio Napoli
Bone scintigraphy evaluates the body segments, in which there is a greater rate of bone remodelling. The widely used tracer that emits ionizing radiation is metastable technetium (99mTc) [58]. The scintigraphic score of 99mTc uptake, which is the sum of the extent and intensity of uptake, represents a valid imaging biomarker that identifies the bone involvement [58,59]. Compared to traditional radiographic examinations, it is a more sensitive method, although it has a low specificity (range from 62 to 89%, with a false-positive rate as high as 40%) [59]. Although planar imaging is widely used, single-photon emission computed tomography (SPECT) imaging, which allows a three-dimensional representation of the skeletal system and the comparison or fusion of images with those of other imaging modalities has demonstrated higher sensitivity [59,60].