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Developmental Social Neuroscience and the Autism Spectrum of Disorders
Published in Christopher J. Nicholls, Neurodevelopmental Disorders in Children and Adolescents, 2018
Given the delineation of these diagnostic criteria, consensual diagnostic strategies have begun to emerge. It has become common that most children with ASD are first identified by primary care physician screening. The Centers for Disease Control suggests but does not endorse multiple tools for pediatric autism screening, including the Ages and Stages Questionnaire (Ages & Stages Questionnaire, 2017); the Communication and Symbolic Behavior Scales (Wetherby & Prizant, 2002); the Modified Checklist for Autism in Toddlers-revised (Robins, Fein, Barton, & Green, 2001); and other screening tools that focus upon the symptoms of autism in toddlers and young children (CDC, 2017). If the outcome of this screening process suggests the possible presence of ASD, the CDC recommends a more comprehensive evaluation be performed by a child development professional.
Treat the Whole, Not the Parts*
Published in Elizabeth B. Torres, Caroline Whyatt, Autism, 2017
Elizabeth B. Torres, Caroline Whyatt
It was at his 9-month visit to our pediatrician for a routine wellness checkup that we were first alerted to the fact that Daniel may face challenges. During this visit, we completed the Modified Checklist for Autism in Toddlers (M-CHAT)—a particularly memorable and, in hindsight, pertinent moment in our journey. Focusing on the task at hand, we were perplexed to notice that Daniel did not fit neatly into the check boxes provided. When marking the presence or absence of behaviors in Daniel, we quickly realized that we needed to improvise by drawing a crude third column (“sometimes,” “not always,” “maybe”). Not knowing that this was screening for the key symptomatology of autism, we did know that Daniel did not fit our understanding of the “commercialized version” as seen in popular movies such as Rain Man. He displayed a clear attachment to both parents and grandparents, was highly affectionate and engaged in a social smile, and displayed no obvious repeated behaviors or rocking. We were unaware of what autism could look like in what people loosely call “high-functioning” individuals, and so we never considered that our son may go on to later receive a diagnosis. This ambiguity also posed a problem for the pediatrician and specialists that we would later work with. Daniel would “flirt” and smile with those evaluating him, engaging in social behaviors such as peekaboo—yet these overt skills masked a level of awkwardness that would not be overly apparent until his later years.
Evaluation of IL1B rs1143634 and IL6 rs1800796 Polymorphisms with Autism Spectrum Disorder in the Turkish Children
Published in Immunological Investigations, 2022
Kubra Cigdem Pekkoc Uyanik, Aysel Kalayci Yigin, Burak Dogangun, Mehmet Seven
The study group consists of 179 individuals. The cases (n = 95) were 2–10 years old children diagnosed with ASD from Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine (CMF) Department of Child and Adolescent Psychiatry. The cases were diagnosed as ASD according to The Diagnostic and Statistical Manual of Mental Disorders (DSM-V) and screened the Modified Checklist for Autism in Toddlers (M-CHAT) scale. Eleven cases had a family history of autism. In the case group, there were 2 pairs of siblings, one of which were dizygotic twins. Patients were excluded from the study if their primary diagnosis was not ASD and if they had a history of neurologic or medical disorder that would affect their neuropsychologic functions. Age-matched, unrelated healthy controls (n = 84) were selected from the Istanbul University-Cerrahpasa, CMF, Department of Pediatrics.
Efficacy of a Telehealth Parent Training Intervention for Children with Autism Spectrum Disorder: Rural versus Urban Areas
Published in Evidence-Based Practice in Child and Adolescent Mental Health, 2022
Angela V. Dahiya, Lisa Ruble, Grace Kuravackel, Angela Scarpa
Participants were recruited through various methods, including flyers posted at the two university sites and support group websites. Eligibility criteria included the following: (a) the child’s age must be between 3 to 12 years; (b) the child must have a DSM-IV or DSM-5 diagnosis of ASD verified by the Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2; Lord et al., 2012); (c) the child must be receiving special education services under the eligibility category of ASD; and (d) the child must be experiencing at least one of the following target problem behaviors: noncompliance, aggression/tantrums, escape behaviors, rigid behaviors, or inappropriate social initiations. Additionally, the participants agreed to the following: random assignment to a condition, audiotaped sessions, commitment to activities related to the condition, and no plans to relocate during the timeframe of the study. Parents and their children completed a screening process which include the completion of the Modified Checklist for Autism in Toddlers (M-CHAT; Robins et al., 2001) or Social Communication Questionnaire (SCQ; Rutter et al., 2003), in which the M-CHAT was administered for children less than 4 years of age and the SCQ was administered for children 4 years of age or older. This screener was followed up by an intake appointment to confirm a diagnosis of ASD, pending the child’s eligibility based on either of the screening measures. Informed consent was obtained from all participants included in the study.
Comparison of tidos with m-chat for screening autism spectrum disorder
Published in Psychiatry and Clinical Psychopharmacology, 2018
Seda Topçu, Betül Ulukol, Özgür Öner, Filiz Şimşek Orhon, Sevgi Başkan
There are many developmental screening tools available to practitioners [8]. Those screening tests are appropriate for young children with ASD who had language and cognitive delays. However, those became problematic for children with other developmental problems and are associated with high false-positive screening results. Parent-report tools often have the advantage of being easy, inexpensive, and practical in the office setting. Modified Checklist for Autism in Toddlers (M-CHAT) is one of those parent-report tools and widely used internationally for screening ASD. It was firstly modified from Checklist for Autism in Toddlers in 2001 [9] and revised with additional follow-up test in 2014 [10]. However, M-CHAT has high false-positive screening results for screening ASD and it leads to increase the concerns of the parents. In different countries, by the validation of M-CHAT, the outcomes for the M-CHAT for screening ASD were reported; Baduel et al. [11] from France and Yıkgeç [12] from Turkey reported that the use of as a screening tool of M-CHAT for ASD was not appropriate because of the high false-positive results of the test.