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Fascial Syndromes
Published in Kohlstadt Ingrid, Cintron Kenneth, Metabolic Therapies in Orthopedics, Second Edition, 2018
The fascia also contains an abundance of cell types including mast cells, T cells, macrophages, lymphocytes, adipocytes and the recently discovered telocytes [6]. Telocytes are mechanosensitive cells that are vital to many physiological processes like stem cell upkeep, tissue repair and immune function. Telocytes share genetic material with other cells via extracellular vesicles. This discovery lends additional credence to the theory that the fascial system is a body-wide, cellular signaling network [7,8].
Angiogenesis and Roles of Adhesion Molecules in Psoriatic Disease
Published in Siba P. Raychaudhuri, Smriti K. Raychaudhuri, Debasis Bagchi, Psoriasis and Psoriatic Arthritis, 2017
Asmita Hazra, Saptarshi Mandal
These cells are elusive but ubiquitous “interstitial cells of Cajal”-like atypical myofibroblastic cells with very long, moniliform processes (telopods with podoms and podomeres) that form an interconnected network and play diverse roles related to communication, pacemaker activity, stem niche formation, and potentially mesenchymal stem cell function. In dermal perivascular adventitia, they have been described as veiled cells by Braverman et al. (1986). Manole et al. (2015) believe that in psoriatic lesions the telocyte network is disrupted and their number is decreased (but recovers after corticosteroid therapy), and they believe that this might explain the mechanistic basis of the Auspitz sign. Telocytes also make contact with endothelial cells, pericytes, smooth muscle cells and play important roles in both vasomotor control and angiogenesis.
Interstitial lung diseases
Published in Louis-Philippe Boulet, Applied Respiratory Pathophysiology, 2017
Dion Geneviève, Cormier Yvon, Boulet Louis-Philippe
A recent study has shown loss of telocytes in the lung of systemic sclerosis (SSc) patients. Telocytes are a type of stromal cell, which may have a role in the regulation of tissue homeostasis, suggesting that this loss could be implicated in the pathogenesis of fibrosis [45].
Investigation of apoptotic and antiproliferative effects of Turkish natural tetraploids Trifolium pratense L. extract on C6 glioblastoma cells via light and electron microscopy
Published in Ultrastructural Pathology, 2023
Gamze Tanrıverdi, Aynur Abdulova, Hatice Çölgeçen, Havva Atar, Belisa Kaleci, Tuğba Ekiz-Yılmaz
Recently, Mitrofanova L et al. explained that glioblastoma consists of different type of cells like pericytes, gliomas, astrocytomas, etc. Some of these cells that are CD117 positive, are also called telocytes (Tcs).41 These unique cells are located in the neighborhood of vessels and are responsible for maintenance of tumor growth and have stem cell like properties. In addition, Mou et al. published that Tcs had contributed to typical tumor formation and promoted the proliferation of tumoral cells along with the other stromal cells.42 And also, Mirancea et al. reported that Tcs seem to promote the tumor formation to become even more invasive.43 In our study, we lost a lot of cells due to the effect of the herb, but also found out that a part of the living cells which stained with immunocytochemistry highly expressed CD117. The presence of this large number of positive cells made us think that these cells that remained unaffected or slightly affected by the drug, might actually be Telocytes. And also, while Trifolium pratense L. is effective on many other cells that are forming the glioblastoma microenvironment, its activity on CD117 positive cells is seen to be limited. As it is known, CD117 is a tyrosine kinase receptor. As a result, tyrosine kinase inhibitors like imatinib are used for treatment of gastrointestinal tumors, Ewing sarcoma and ovarian cancers that are rich in CD117 positive cells.44 When we look from this aspect, we think that Trifolium pratense L. can be more effective when used together with tyrosine kinase inhibitors like imatinib.
Telocytes, c-Kit positive cells, Smooth muscles, and collagen in the ureter of pediatric patients with congenital primary obstructive megaureter: elucidation of etiopathology
Published in Ultrastructural Pathology, 2021
Mohamed Wishahi, Ehab Hafiz, A M K Wishahy, Mohamed Badawy
The interstitial cells of Cajal (ICC), a peculiar type of cells reported in most tissues so far examined with multiple functions including pace-maker activity.12,13 Telocytes (TCs) are distinct population of interstitial cells and was described to play a role in conducting electrical information and characterized by their long, thin processes termed telopodes. Numerous studies determined that mostly all tissues have TCs and were attributed to various functions as smooth muscles connectivity, and tissue regeneration.1,13,14
Recent insights into human bronchial proteomics – how are we progressing and what is next?
Published in Expert Review of Proteomics, 2018
Heng Wee Tan, Yan-Ming Xu, Dan-Dan Wu, Andy T. Y. Lau
The air is filled with potentially harmful airborne particles/substances that may elicit lung-related diseases and complications (Figure 1). The lung is equipped with several defense mechanisms to deal with these unwelcome objects. First of all, the inner surface of trachea and primary bronchi that come into direct contact with inhaled air is lined with epithelial cells with cilia (involved in mucociliary clearance) and is covered with a layer of protective lung-lining fluid [3]. The tracheobronchial epithelium contains goblet cells that produce mucus to trap foreign substances [4]. The terminal and respiratory bronchioles have no goblet cells but club (Clara) cells in their epithelial lining that secrete a range of proteins involved in the protection, reparation, regeneration, and structural support of bronchiolar epithelium, as well as in the defense against foreign substances that managed to pass through the primary bronchi [5]. The alveoli are made up of three main cell types: the epithelial (type I) cells that form the alveolar wall, the septal (secretory; type II) cells that secrete surfactant and function similarly to the bronchiolar club cells, and the macrophages [6]. Alveolar macrophages are phagocytic white blood cells capable of engulfing and destroying harmful microbes and substances through phagocytosis, and they are responsible for initiating inflammatory and immune responses in the lung [4]. Myeloid cells that are involved in the innate immune system, such as dendritic cells, monocytes, and neutrophils, can also be found in the lung [6]. A newly defined cell type, the telocytes, can be found throughout the respiratory system, including the tissues and interstitial space of the trachea, bronchioles, and alveoli [7]. Telocytes play an important role in intercellular signaling and may be involved in regulating lung inflammation and the pathogenesis of lung diseases.