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Hormones of the Moss Protonema
Published in R. N. Chopra, Satish C. Bhatla, Bryophyte Development: Physiology and Biochemistry, 2019
To study this problem the enzyme which removes the side chain from kinetin, kinetin oxidase (cytokinin oxidase), was extracted and analyzed in vitro. In Figure 11 it is shown that the enzyme is very active on kinetin. After 24 h about 35 to 40% of the initial radioactivity of 14C-labeled kinetin could be detected in adenine and 10% in hypoxanthine, whereas BAP (Figure 12) was practically not degraded to adenine, but was very strongly metabolized to the benzyladenine ribotide and riboside, from which the benzyl group could then be removed.101,102
Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery
Published in Expert Opinion on Drug Discovery, 2018
Balaguru Ravikumar, Tero Aittokallio
Traditional molecular docking approaches in drug discovery involve virtual screening compound libraries against a given target to identify potential lead molecules. Recent advancements in computational efficiency have facilitated the optimization of standard docking algorithms to address specific demands when predicting off-targets or identifying drug repositioning opportunities. Such docking strategies are termed as inverse or reverse docking, wherein a given compound can be virtually screened across multiple targets. There are currently only few docking algorithms that have successfully implemented inverse docking strategy, including idTarget, INVDOCK, and DRAR-CPI [56–58]. For instance, a recent study by Kumar et al. revealed seven novel targets for kinetin using idTraget algorithm, four of which were experimentally validated [59]. Similarly, Ye et al. used PharmMapper [60] in combination with DRAR-CPI to identify a potentially novel target for capsaicin [61]. These inverse docking algorithms are often followed by a target ranking schema based on comparing the docking score, affinity profile or target-ligand profile to identify the most potent targets.
Melatonin-stimulated biosynthesis of anti-microbial ZnONPs by enhancing bio-reductive prospective in callus cultures of Catharanthus roseus var. Alba
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Hafiza Rida Riaz, Syed Salman Hashmi, Tariq Khan, Christophe Hano, Nathalie Giglioli-Guivarc’h, Bilal Haider Abbasi
Callogenesis occurred on media supplemented with NAA, 2,4-D, kinetin and TDZ (2.25 µM, 4.5 µM, 9 µM and 13.5 µM). NAA, 2,4-D and NAA showed the best responses over callogenesis (Figure 2), while even a single concentration of kinetin did not show any response for callus induction.
Book Reviews
Published in Journal of Dermatological Treatment, 2020
Sivamani's 3rd edition complements the previously reviewed book by Draelos. The chapters specifically summarize the evidence for their use in dermatology. Individual chapters include caffeine, kinetin, resveratrol, and the expanding information on niacinamide.