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Blood
Published in T.M. Craft, P.M. Upton, Key Topics In Anaesthesia, 2021
FFP can further be separated into cryoprecipitate and supernatant. Cryoprecipitate is rich in factor VIII and fibrinogen. Supernatant contains albumin, factor IX and immunoglobulins. Human albumin solution has a shelf life of about 2 years and is available as 4.5% and 20% solutions.
Transfusion products
Published in Jennifer Duguid, Lawrence Tim Goodnough, Michael J. Desmond, Transfusion Medicine in Practice, 2020
Furthermore, the Cochrane Injuries Group 1998 systematic review of human albumin concluded that there was no evidence that albumin reduces mortality in patients with hypovolaemia, burns, and hypoalbuminaemia, and also concluded that albumin might increase mortality.40
Concepts of Replacement Therapy: Blood Components, Blood Derivatives, and Medications
Published in Harold R. Schumacher, William A. Rock, Sanford A. Stass, Handbook of Hematologic Pathology, 2019
Human albumin and plasma protein fraction (PPF) are also prepared by fractionation of pooled human plasma. These products are heat treated, and are generally accepted to be virally safe. Albumin is available as a 5% or 25% solution, in which 96% of the total protein is albumin. PPF is a 5% solution with albumin comprising 83% of the total protein. These products provide volume expansion and colloid (oncotic) replacement in hypovolemic states.
Serum Albumin as a Predictor of Survival after Interval Debulking Surgery for Advanced Ovarian Cancer (AOC): A Retrospective Study
Published in Journal of Investigative Surgery, 2022
Dairui Dai, Janos Balega, Sudha Sundar, Sean Kehoe, Ahmed Elattar, Andrew Phillips, Kavita Singh
Our data suggests that if serum albumin can be normalized and complete cytoreduction achieved, a survival advantage may be obtained. Theunclear role of albumin as a marker of nutrition and a negative acute phase protein poses issues in the interpretation of serum albumin levels and, specifically, any change in serum albumin levels. Experimental studies have established that serum albumin levels are a poor reflection of prolonged starvation and inflammation, without malnutrition, independently caused hypoalbuminaemia [7, 21]. In the highly inflammatory environment of advanced cancer, the cause of hypoalbuminaemia is unclear, although various mechanisms have been proposed [9]. There is a clear relationship between reducing tumor burden and improving albumin levels with NACT. However, without a clearer understanding of the mechanisms behind hypoalbuminaemia, serum albumin levels cannot be utilized as anything more than a surrogate predictive marker. Conversely, correcting albumin has been a controversial topic in medical literature. It has long been observed that without correction of the underlying disease process, serum albumin is not predictably increased through refeeding or with administration of human albumin solution [22, 23]. Further work is required to clarify whether disease manipulation, using chemotherapy or pre-operative nutritional/other optimization techniques, is the main driver of the improved albumin seen in this study.
Development of liposome as a novel adsorbent for artificial liver support system in liver failure
Published in Journal of Liposome Research, 2020
Yue Shen, Yifeng Wang, Yuanyuan Shi, Huajun Tian, Qiuyu Zhu, Feng Ding
Orthotropic liver transplantation has been the best defined treatment for patients suffering from acute liver failure (ALF), acute-on-chronic liver failure, and decompensated end-stage liver disease, in which injured livers are unable to regenerate or recover (Faybik and Krenn 2013). However, because of the deficiency of suitable organ donors and the short time span available for liver transplantation, many patients become ineligible for liver transplantation or die in the waiting line. Under such circumstances, a number of extracorporeal liver support or liver dialysis systems have been created and developed in the past decades to serve as bridging therapies to transplantation or supportive therapies for patients with liver failure. Represented by the Molecular Adsorbent Recirculating System™ (MARS™), the albumin dialysis (AD) system has proved the improvement of certain biochemical parameters without causing a notable elevation in the incidence of adverse events (Banares et al. 2014). Promising as albumin dialysis is, its application has been somehow restricted by the large amount of human albumin consumed during albumin dialysis treatments.
Effect of intraoperative dexmedetomidine on renal function after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a randomized, placebo-controlled trial
Published in International Journal of Hyperthermia, 2019
Young Song, Do-Hyeong Kim, Tae Dong Kwon, Dong Woo Han, Seung Hyuk Baik, Hwan Ho Jung, Ji Young Kim
Hemodynamic monitoring included the cardiac index (CI) and stroke volume variation (SVV) derived from the VigileoTM System (Edwards Lifesciences, Irvine, CA) and central venous pressure (CVP) obtained from the internal jugular vein. Anesthesia was maintained with sevoflurane inhalation and remifentanil infusion. Mean arterial pressure (MAP) was maintained between 60 and 80 mmHg with adequate fluid resuscitation and the use of norepinephrine. Goal-directed fluid therapy was performed under the guidance of SVV with concomitant consideration of preoperative deficit, maintenance and surgical loss. Balanced crystalloid (Plasma Solution A Inj.; CJ Pharma, Seoul, Korea) was administered as a primary resuscitation fluid and balanced synthetic colloid (Volulyte; Fresenius Kabi, Bad Homburg, Germany) was administered up to 1000 ml to compensate for blood loss. Packed red blood cells (pRBC) were transfused when the hematocrit was <25%. A 20% human albumin solution (SK chemical, Seoul, Korea) was administered to maintain serum albumin concentration at >2.0 g/dL. Active cooling with a cooling mattress forced air and infusion of cold fluids was performed during HIPEC. After surgery, all participants were transferred to the ICU with or without extubation at the attending anesthesiologist’s discretion. Postoperative care was performed by the attending physician and intensivist.