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Benign Disorders of Leukocytes
Published in Harold R. Schumacher, William A. Rock, Sanford A. Stass, Handbook of Hematologic Pathology, 2019
Gene L. Gulati, Zoran Gatalica, Bong H. Hyun
Based on clinical findings, the laboratory evaluation of basophilia, particularly persistent basophilia, may include any of the following studies: Blood smear examinationTest(s) for suspected or identified underlying condition(s)Bone marrow examination, if a malignancy is suspectedCell marker studies, as needed, to establish or confirm the specific cell lineage.
Reproductive System and Mammary Gland
Published in Pritam S. Sahota, James A. Popp, Jerry F. Hardisty, Chirukandath Gopinath, Page R. Bouchard, Toxicologic Pathology, 2018
Justin D. Vidal, Charles E. Wood, Karyn Colman, Katharine M. Whitney, Dianne M. Creasy
The most recent basophilic corpora lutea in the ovary have attained their greatest diameter and begin to have an eosinophilic appearance (Figure 20.26d). Apoptotic cells are not present in the corpora lutea and this may help distinguish diestrus from proestrus. The uterine lumen is narrow and lined by low columnar epithelial cells and mitotic figures are common; granulocytes tend to be less prominent in the endometrial stroma. At the end of metestrus and beginning of diestrus, the vaginal epithelium has reached its thinnest appearance, consisting of 3–6 layers of the stratum germinativum (Figure 20.27d). Infiltration of the epithelium by neutrophils is often still present in mice. As diestrus progresses, the epithelium increases in thickness to 8–10 layers and the superficial layers of cells start to become polygonal and slightly basophilic as early mucification occurs.
Benzene Hematotoxicity
Published in Muzaffer Aksoy, Benzene Carcinogenicity, 2017
Some investigators have reported eosinophilia in chronic benzene toxicity. Heim de Balzac and Lafont125 reported that eosinophilia may occur without concomitant changes in other blood parameters. Duvoir and Derobert126 have corroborated this. In their study, relative eosinophil values greater than 5% were found in 21.8% of the 555 workers. One case had 18.1% eosinophils. Savilahti40 found eosinophils above 6% in 18 workers. In one case the eosinophils reached 15.5%. Hernberg et al.127 studied the eosinophil values in 120 out of 144 workers who were exposed heavily to benzene 10 years prior.40 According to this study, following a 10-year cease of exposure, the eosinophilia had evidently decreased, thus suggesting that the high rate of eosinophilia, ranging between 0 and 15.5%, was due to the effect of benzene. Sungur128 reported eosinophils above 3% in 28.2% of the workers studied. It should be pointed out that all these studies accept low eosinophil values as normal. Today, relative eosinophil values up to 8% have come to be considered normal.129 In our study we found eosinophilia in 5 workers, that is 2.3% of the 217 workers.64 Eosinophil values were in the range of 8 to 39%. If the one case involving both basophilia and eosinophilia is added to this number, the ratio becomes 2.76%. However, this finding was not statistically significant.
Basophilia of the peripheral blood in patients with ulcerative colitis
Published in Scandinavian Journal of Gastroenterology, 2020
Omid Amouzadeh-Ghadikolai, Gerhard Reicht, Franz Quehenberger, Christoph Robier
Furthermore, we examined the medical records of the study participants with basophilia in order to obtain clinical information. One patient with left-sided CU and one with pancolitis had acute flares; two patients suffered from an acute flare and therapy-refractory pancolitis leading to proctocolectomy. Basophilia remained after surgery in these cases. Three patients were proctocolectomized several years ago and three showed a stable disease. Overall, patients with stable disease or status post proctocolectomy showed mild elevations of the basophil count, whereas most of the patients with acute flares and severe disease showed basophil counts near to or above 300/µL. However, the number of patients with basophilia was too low to calculate a correlation with the severity of CU.
High absolute basophil count is a powerful independent predictor of inferior overall survival in patients with primary myelofibrosis
Published in Hematology, 2018
Marko Lucijanic, Ana Livun, Tajana Stoos-Veic, Vlatko Pejsa, Ozren Jaksic, David Cicic, Jelena Lucijanic, Zeljko Romic, Biserka Orehovec, Gorana Aralica, Marko Miletic, Rajko Kusec
Besides factors included into the currently established prognostic scores, a variety of other disease-associated parameters can contribute to better prognostic discrimination in PMF patients, such as lactate dehydrogenase (LDH) levels [9], red cell distribution width (RDW) [10] and monocytosis in the peripheral blood [11]. Elevation in the number of circulatory basophils is a known feature of both chronic myelogenous leukemia (CML) and Ph-MPNs [12–15]. In CML, basophilia is recognized as an important diagnostic and prognostic parameter and it is included into the variety of prognostic scores [16–19]. However, there are limited insights into the possible role of basophils in Ph-MPNs [20] and their role in the pathogenesis and prognosis of PMF patients is currently unknown.
Role of blood inflammatory cells in chronic rhinosinusitis with nasal polyps
Published in Acta Oto-Laryngologica, 2019
Giuseppe Brescia, Paolo Sfriso, Gino Marioni
Basophils are the rarest granulocytes, but recent studies have demonstrated that they have a crucial, non-redundant role in the immune system. Basophils can be expanded by thymic stromal lymphopoietin (TSLP), which is expressed in significant amounts in nasal polyp epithelial cells from patients with chronic rhinosinusitis. Once recruited and activated in response to a variety of stimuli, basophils release IL-4 in both an immunoglobulin E (IgE)-dependent and an IgE-independent manner. It is widely accepted that IL-4 plays a major part in promoting the differentiation of naïve CD4+ T cells into Th2 cells, and contributes to innate lymphoid cell activation. Basophil-derived IL-4 particularly enhances the expression of IL-5, IL-13, IL-33, and γ-interferon in type 2 innate lymphoid cells, leading to the accumulation of eosinophils [10]. Tissue basophilia in CRSwNP has very rarely been investigated. Mahdavinia et al. [11] found a significantly higher number of basophils in the nasal polyp tissue than in the uncinate tissue of both controls and patients with chronic rhinosinusitis without AERD. Basophil levels showed a significant positive correlation with eosinophil levels in polyps, suggesting a coordinated recruitment or survival of these two important effectors in type 2 immune responses in nasal polyps. The authors hypothesized that, in an environment rich in potential activators, and considering their ability to produce multiple inflammatory mediators, basophils could make an important contribution to the pathogenesis chronic rhinosinusitis. In a retrospective study conducted by Brescia et al. [9] on 280 patients with CRSwNP, the patients’ blood eosinophil and basophil counts and percentages were strongly correlated. An earlier study of ours also found significant direct associations between recurrent CRSwNP and blood basophil counts and percentages [12]. In a recent investigation on CRSwNP that aimed to identify the best-fitting cutoffs for binarizing preoperative blood basophil levels for prognostic purposes, patients with basophil counts ≥0.03 cells ×109/L and percentages ≥0.5% had ORs of 2.19 and 2.24, respectively, for disease relapse [9].