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Common Medicines from Herbs, Minerals and Animal Sources
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
Zingiber officinale or ginger belongs to the family Zingiberaceae (similar to turmeric and cardamom) and is among the most frequently used herbs and flavouring agents all around the world (Surh, 1999). The spicy smell of ginger is primarily because of the existence of ketones, particularly gingerols, which emerge to be the principal constituent of ginger researched in most of the health-associated scientific studies. The most consuming part of ginger is a rhizome which also has medicinal properties. Chinese and Indians are believed to have discovered ginger as a tonic for health more than 5,000 years ago to manage numerous diseases, and this herb is nowadays growing in all tropical regions, though India is its biggest producer (Bode & Dong, 2011).
Biological Effects of Ayurvedic Formulations
Published in D. Suresh Kumar, Ayurveda in the New Millennium, 2020
G.R. Arun Raj, Kavya Mohan, R. Anjana, Prasanna N. Rao, U. Shailaja, Deepthi Viswaroopan
Sahacarādi kvātha contains only three ingredients – Zingiber officinale, Cedrus deodara and Barleria prionitis (Vaidyan and Pillai 1985c). In this recipe, Zingiber officinale acts as an improver of “digestive fire” and Cedrus deodara pacifies vāta. Sahacaram means “walking along with”. As Barleria prionitis has the specific property of gativiśēṣatvam (ability to cause movement), Sahacarādi kvātha can be administered in conditions like difficulty in walking or improper walking. The combination of all these drugs is therapeutically effective in lower back pain, sciatica, debility of lower limbs (Supraja and Vidyanath 2013) and chronic rheumatoid arthritis with bilateral hip involvement (Mamidi and Gupta 2015; Nimesh and Shetty 2018) It is also effective in nerve-related diseases like hemiplegia, epilepsy (Kumar et al. 2018), disc prolapse, facial palsy and paralysis (Ratha et al. 2018).
Role of Natural Agents in the Management of Diabetes
Published in Rohit Dutt, Anil K. Sharma, Raj K. Keservani, Vandana Garg, Promising Drug Molecules of Natural Origin, 2020
Monika Elżbieta Jach, Anna Serefko
The main bioactive compounds of Zingiber officinale are gingerol, shogaol, and zerumbone. Whereas shogaol, and zerumbone exert the antioxidant effects, gingerol is particularly responsible for the antidiabetic potential of ginger (Rahman et al., 2014). It was demonstrated that ginger inhibits α-amylase, α-glucosidase, and enzymes involved in gluconeo-genesis and glycogenolysis, enhances insulin sensitivity and its release, increases glucose uptake through translocation of the GLUT4 to the cell surface and improves the lipid profile (Li. et al., 2012). Mozaffari-Khosravi et al. (2014) have shown that daily administration of ginger powder (3 g for 8 weeks) may improve insulin resistance and reduce both FBG and HbA1c values.
The role of ginger’s extract and N-acetylcysteine against docetaxel-induced oxidative stress and genetic disorder
Published in Drug and Chemical Toxicology, 2023
Farzaneh Motafeghi, Parham Mortazavi, Amir Hossein Salman Mahiny, Mohammad Mehdi Abtahi, Mohammad Shokrzadeh
Ginger, scientifically known as Zingiber officinale, is a plant of the Zingiberaceae family. It is a herbaceous perennial which grows annual pseudostems (false stems made of the rolled bases of leaves) which are about one meter tall and also bear narrow leaf blades. It is indigenous to Southeast Asia, and for centuries, it has played an essential role in Chinese, Ayurvedic, and Unani-Tibb herbal medicine for disease treatment. It has been highly theorized that ginger could benefit human health due to its antioxidant properties. The main components of ginger are 6-gingerol, 6-shogaol, 8-gingerol, and 10-gingerol. These constituents have previously demonstrated potent in-vitro antioxidant activity. Ginger extract has shown to reduce oxidative stress and increase plasma non-enzymatic antioxidant capacity (de WAARD and ANUNCIADO 1999, Atashak et al. 2014). It has been used as a spice and herbal medicine throughout time (Han et al. 2013, Mao et al. 2019). Ginger is rich in phenolic and terpenes compounds such as gingerol, shogaol, polysaccharides, lipids, and fiber (Stoner 2013). Studies have shown that ginger extract has antioxidant, anti-inflammatory, and anti-apoptotic activity. It has also been shown to increase the activity of antioxidant factors such as SOD, catalase, and GPx. The results of cellular and molecular studies have shown that ginger can also inhibit oxidative stress factors (Hosseinzadeh et al. 2017).
Preventive Effect of Combined Zingiber officinale and Terminalia chebula against DMBA-Induced Breast Cancer Rats via mTOR Inhibition
Published in Nutrition and Cancer, 2022
Jayasindu Mathiyazhagan, Ramamoorthy Siva, Rama Jayaraj, Harishkumar Madhyastha, Gothandam Kodiveri Muthukaliannan
Breast cancer is the most prevalent form of cancer affecting women and is the second most common cause of cancer deaths globally (1). Breast cancer incidence is higher in younger (premenopausal) women (2). Overall mortality and morbidity emphasize the need to prevent breast cancer at its earliest. Tamoxifen is an estrogen receptor modulator that has been used for hormone therapy for the treatment of breast cancer. However, prolonged usage of this drug can cause serious complications such as stroke (3), pulmonary embolism (4), and retinal vein occlusion (5). A myriad of studies have shown the various effects of herbal and dietary compounds in cancer prevention (6). Thus, identifying dietary and herbal products with anticancer potential might provide an alternative for a treatment with significantly lower toxicity and at the same time readily available for all patients. Zingiber officinale (ZO) rhizome is a dietary product used in traditional medicine for diverse ailments such as migraine, arthritis, depression, high cholesterol, diabetes, and cancer (7, 8). Terminalia chebula (TC) fruit is well known in traditional medicine as a cardiotonic, antidiabetic, and anticancer agent (9). Many herbal/ayurvedic formulations (National Library of Ayurved Medicine) use a combination of ZO and TC. However, their combined property is yet to be validated scientifically.
A systematic review of the efficacy of alternative medicine in the treatment of nausea and vomiting of pregnancy
Published in Journal of Obstetrics and Gynaecology, 2020
Fahimeh Khorasani, Hossein Aryan, Abousaleh Sobhi, Reihaneh Aryan, Arefeh Abavi-Sani, Masumeh Ghazanfarpour, Masumeh Saeidi, Fatemeh Rajab Dizavandi
The search was undertaken by two separate reviewers on PubMed, Cochrane Library, and Scopus databases since inception until January 14, 2019 to investigate the effects of herbal medicines on NVD, using keywords such as (Pregnant OR pregnancy) AND (emesis OR anti-emetic OR Nausea OR vomit OR morning sickness), AND (Complementary treatments OR alternative treatments OR phytomedicine, herbal treatments, zingiber officinale OR Ginger OR Citrus lemon OR lemon OR Matricaria chamomilla OR Citrus medica L OR alternative medicine OR complementary medicine OR Citron OR Cydonia oblonga mill OR Quince OR Elletaria cardamomum OR Cardamom OR, Mentha spicata L. OR Spearmint OR, Mentha piperta L OR Mint OR Myristica fragrans Houtt OR Nutmeg OR Pistacia lentiscus Linn OR Mastic, Punica granatum L OR Pomegranate OR Malus domestica Borkh OR Apple OR Piper cubeba) . The researchers reviewed all abstracts and then the full-texts of relevant articles were found. Any disagreement was resolved by a third party.