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Herbs with Antidepressant Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
Chronic consumption of yerba mate tea has been found to be useful against obesity and in improving the lipid parameters in humans and animal models. Animal studies have shown that yerba mate modulates signaling pathways that regulate adipogenesis, antioxidant, anti-inflammatory, and insulin signaling responses.7 Such a combination of effects would likely be useful in the treatment of depression. Water extracts of yerba mate have been shown to improve markers of insulin resistance and inflammation in mice made obese with high fat diets. Treatment reduced glucose blood level and improved insulin sensitivity in liver and soleus muscle. In liver tissue, insulin substrate receptor (IRS)-1 and AKT phosphorylation were restored. Treatment also reduced serum levels of the inflammatory cytokines TNF-α and IL-6.8 In a study of human subjects that were pre-diabetic, consumption of yerba mate tea promoted a significant increase of GSH concentration and a decrease of serum lipid hydroperoxides.9
Mode of Action of Selected Botanicals That Lower Blood Glucose
Published in Robert Fried, Richard M. Carlton, Type 2 Diabetes, 2018
Robert Fried, Richard M. Carlton
Yerba mate tea is made from the leaves of mate, Ilex paraguariensis (Aquifoliaceae), which is gaining popularity in South America. A study published in the journal Phytomedicine aimed to determine the effects of an aqueous extract of mate (pronounced ma-tay) on metabolic syndrome features in a metabolic syndrome model Tsumura Suzuki obese diabetic mouse.
Anxiety and depression
Published in Hilary McClafferty, Mind–Body Medicine in Clinical Practice, 2018
In any patient with anxiety, it is important to consider and rule out clinical conditions that can present with features of anxiety such as thyroid disorders, pheochromocytoma (adrenal gland tumor that produces adrenaline), and the use of any exacerbating food, caffeinated beverages, sympathomimetics, beta-agonists, corticosteroids, thyroid supplements, stimulant medications, drugs of abuse, or over-the-counter products with caffeine or other stimulant ingredients. Certain dietary supplements such as S-adenosylmethionine (SAM-e) typically used for osteoarthritis pain and depression can cause anxiety in some individuals. Yerba mate is another popular natural product high in caffeine, typically prepared as a tea.
Enzyme-assisted modification of flavonoids from Matricaria chamomilla: antioxidant activity and inhibitory effect on digestive enzymes
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Elida Paula Dini de Franco, Fabiano Jares Contesini, Bianca Lima da Silva, Anna Maria Alves de Piloto Fernandes, Camila Wielewski Leme, João Pedro Gonçalves Cirino, Paula Renata Bueno Campos, Patrícia de Oliveira Carvalho
Though a number of polyphenols have been reported as inhibitory to the action of digestive enzymes in vitro, only a limited number of reports have diagnosed their mode of inhibition, showing, however, contradictory results. For instance, phenolics from the methanolic extract of finger millet seed coat showed strong inhibition towards glucosidase and pancreatic amylase with non-competitive inhibition35, while phenolic acids from potato cultivars acted as effective mixed inhibitors for α-amylase and α-glucosidase and non-competitive inhibitors for aldose reductase36. Main polyphenols in yerba maté (chlorogenic acids, caffeoylquinic acids, dicaffeoylquinic acids) competitively inhibited pancreatic lipase activity in a concentration-dependent manner with an IC50 value of 1.5 mg MT/ml8. Such a variation in inhibitor potency, as well as the mode of enzyme inhibition, is not unusual since the inhibitor potency of polyphenolic compounds depends on several factors, such as the structure and stability of the inhibitors.
Evaluation of Natural Product Compositions for Appetite Suppression
Published in Journal of Dietary Supplements, 2019
Mesfin Yimam, Ping Jiao, Mei Hong, Lidia Brownell, Young-Chul Lee, Eu-Jin Hyun, Hyun-Jin Kim, Tae-Woo Kim, Jeong-Bum Nam, Mi-Ran Kim, Qi Jia
Morus alba root bark extract was produced by 70% ethanol extraction of the ground root bark powder with not less than 10% total bioflavonoids including kuwanon G, albanin G, and morusin. Magnolia officinalis bark was extracted by a supercritical fluid and further crystalized to give a mixture of magnolol and honokiol at about 1:1 ratio with content higher than 90% of those two compounds. Ilex paraguayensis leaf was extracted with water to give yerba mate extract containing not less than 4% caffeine. The dried powders of Magnolia officinalis bark extract, Morus Alba root bark extract, and Ilex paraguariensis leaf extracts were mixed at a proprietary ratio to produce the standardized UP601 composition.
Associations between urinary caffeine and caffeine metabolites and cognitive function in older adults
Published in Nutritional Neuroscience, 2023
Xihang Fu, Huiru Li, Xinzhen Chen, Jinliang Cai, Ting Yao, Lingling Song, Manqiu Cen, Jing Wu
Cognitive dysfunction is caused by multiple factors, such as genetics, demographics, socioeconomics and diet [4,5]. As neuroinflammation and oxidative stress are involved in the pathomechanism of AD, antioxidant nutrients, such as caffeine, have attracted increasing attention [6]. Caffeine is present in daily beverages and some foods, such as coffee, tea, yerba mate, soft drinks, energy drinks and cocoa-containing foods. Recent studies have indicated that the majority (approximately 85%) of the US population consumes at least one caffeinated drink per day [7]. In addition, previous studies have documented the beneficial effects of caffeine on the cardiovascular system, diabetes, and neuroinflammation [8–10].