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Assyria
Published in Michael J. O’Dowd, The History of Medications for Women, 2020
Another agent ‘for uterine disease’ in the Assyrian Herbal was storax (from Styrax officinalis). Much used as incense during church ceremonies the plant contains benzoic acid and is in medical use as Benzoin Tincture Co., (The British Pharmacopoeia, 1932 pp. 438–9; Reynolds and Prasad, 1982 p. 314). An effective antifungal agent, it was combined with salicylic acid in Whitfield’s ointment (Harvey, 1985 p. 973). It is tempting to think that the Assyrians could have prescribed it for ‘uterine’ (possibly meaning uterus and genital tract) itch and discomfort. It is currently in vogue as treatment for ‘cracked’ nipples caused by breastfeeding.
W
Published in Anton Sebastian, A Dictionary of the History of Medicine, 2018
Whitfield Ointment Benzoic and salicylic acid, used for treatment of fungal infections. Formulated by London dermatologist, Arthur Whitfield (1867–1947). He graduated from King’s College in 1892 where he was professor of dermatology in 1906.
Rural diseases
Published in Jim Cox, Iain Mungall, Rural Healthcare, 2017
Treatment with a topical imidazole cream, such as clotrimazole or miconazole, is normally adequate. Occasionally a keratolytic such as Whitfield’s ointment can be effective. Improvement can be expected within one week and a cure within one month. For severe cases griseofulvin (500 mg daily by mouth for at least a month) may be necessary. For griseofulvin-resistant cases, oral terbinafine is effective.
Nanotechnological interventions in dermatophytosis: from oral to topical, a fresh perspective
Published in Expert Opinion on Drug Delivery, 2019
Riya Bangia, Gajanand Sharma, Sunil Dogra, Om Prakash Katare
Butenafine is another drug that shows potent anti-dermatophytic action along with fungicidal activity against Aspergillus, dimorphic, and dematiaceous fungi. Moreover, it has anti-inflammatory activity. FDA has approved butenafine 1% cream for treating interdigital tinea pedis, tinea corporis, and tinea cruris [37]. According to Thaker et al., topical 1% butenafine is found to have more efficacy, low cost, and equal safety in comparison to 2% sertaconazole but less efficacious, cost-effective, and safe than Whitfield’s ointment consisting of weekly 150 mg dose of oral fluconazole for the management of tinea infections [38,39].