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The Roman Empire
Published in Scott M. Jackson, Skin Disease and the History of Dermatology, 2023
Within the pages of De medicina can be found the first use of the term, tinea, the medical term used today for the fungal infection that the layperson calls ringworm. The word tinea in Latin translates to a type of worm that puts holes in books or clothing. Since the condition frequently presents with ring-shaped lesions, it is easy to see how ringworm developed as the term for this condition. Cassius Felix's description of tinea, however, sounds more like what is known today as favus in that it describes a thick and viscous humor, similar to honey, emitted by the skin from holes in the skin.
Ringworm/Dermatophytosis/Tinea Infections
Published in Charles Theisler, Adjuvant Medical Care, 2023
Ringworm, also known as dermatophytosis, is not a worm but a fungal (tinea) infection of the skin. The fungi live on the dead tissues of the skin, hair, and nails. Tinea infections are commonly referred to as ringworm due to the characteristic circular lesions. These infections are named for the affected body part, such as tinea pedis (feet), tinea capitis (scalp), and tinea corporis (body). Typically, it results in a circular red, itchy, scaly rash. Ringworm occurs in people of all ages, but it is particularly common in children. It occurs most often in warm, moist climates. Ringworm is a contagious disease and can be passed from person to person by contact with infected skin areas or by sharing combs and brushes, other personal care items, or clothing.'
Chronic erythematous rash and lesions on trunk and limbs
Published in Richard Ashton, Barbara Leppard, Differential Diagnosis in Dermatology, 2021
Richard Ashton, Barbara Leppard
Ringworm of the body is due to an infection with one of the dermatophyte fungi of the Microsporum, Trichophyton and Epidermophyton species. Dermatophytes live on keratin so the clinical picture is of one or more pink scaly papules or plaques, which gradually extend outwards healing from the centre and forming a ring (Fig. 8.23).
Fenticonazole nitrate loaded trans-novasomes for effective management of tinea corporis: design characterization, in silico study, and exploratory clinical appraisal
Published in Drug Delivery, 2022
Rofida Albash, Maha H. Ragaie, Mahmoud A. El Hassab, Radwan El-Haggar, Wagdy M. Eldehna, Sara T. Al-Rashood, Shaimaa Mosallam
Fungal diseases are becoming more common these days. They have greater toxic side effects encountered with traditional systemic therapy (Kumar et al., 2014). Tinea corporis, also known as ringworm, is a dermatophytosis (superficial fungal infection especially on the skin) (Merad et al., 2021). The therapeutic efficacy of medication applied topically is mainly determined by its capability to enter and penetrate the skin. Thereby, the development of an innovative drug delivery system will produce better outcomes owing to passing the stratum corneum (SC) and targeting the site of infection (Mosallam et al., 2021a). Fenticonazole nitrate (FTN) is an antifungal agent that belongs to imidazoles. It works by blocking ergosterol production and therefore damaging the cell membrane (Campos et al., 2018). FTN has both fungistatic and fungicidal properties against yeasts, fungi, and dermatophytes. It also inhibits the growth of gram-positive bacteria (Jung et al., 1988). Hence, FTN is thought to be a promising topical agent for treating skin fungal infections. Unfortunately, the low aqueous solubility of FTN (<0.10 mg/mL) (Albash et al., 2020) arouses the need for designing a new vesicular system to deliver FTN effectively and compel cure of fungal infections.
Sodium thiosulfate protects from renal impairement following hyperthermic intraperitoneal chemotherapy (HIPEC) with Cisplatin
Published in International Journal of Hyperthermia, 2020
N. Laplace, V. Kepenekian, A. Friggeri, O. Vassal, F. Ranchon, C. Rioufol, W. Gertych, L. Villeneuve, O. Glehen, N. Bakrin
As a nonspecific agent, ST has been used for many years in variable and heterogeneous indications. In nephrology, its chelation of cations led to it being used for the treatment of calciphylaxis occurring in patients under dialysis [11]. Historically, it has been used for the treatment of ringworm or as an antifungal agent, and its use is also described in the management of cyanide poisoning [25]. It has antioxidant properties related to its reaction with oxidized glutathione and reactive oxygen species leading to the formation of glutathione, a natural antioxidant; it would therefore restore the functions of endothelial cells. In addition, ST also interacts with various enzymes by transsulfurization producing hydrogen sulfite, a vasodilator at the microcirculatory level. The plasma concentration of ST increases linearly with the injected dose. The half-life of the plasma distribution phase is approximately 23 min. Regarding its elimination, some of the injected ST is oxidized into sulfite and then into sulfate at the hepatic level. Only a small fraction of thiosulfate is incorporated into the endogenous sulfur compounds. ST is then mainly eliminated by the renal route, by glomerular filtration, and secretion. In healthy subjects, renal clearance is approximately 1.86 ml/min/kg and non-renal clearance is 2.25 ml/min/kg, for an elimination half-life of approximately 16–80 minutesr. The reported side effects of ST are rare. Metabolic acidosis and a QT prolongation in patients with chronic renal impairment or dialysis patients were reported; furthermore possible anaphylactic reactions have been described, but none of these adverse effects were found in the present study.
Medical social workers as mediators between patients, physicians, and the court: the case of former ringworm patients
Published in Social Work in Health Care, 2020
Dan Even, Shifra Shvarts, Dorit Segal-Engelchin
Until the 1960s, scalp ringworm was one of the most widespread fungal diseases in children and remained a major public health issue, concentrated in communities with a high prevalence of malnutrition, poverty, and neglect (“Author”, 2010, 2013). This was not singular to Israel: Reports of ringworm infections in the USA date back to 1900; several documents describe a high prevalence of the disease among immigrating children arriving at the Ellis Island intake facility in New York, where ringworm was among the diseases – minor and major, that were grounds for barring entry into the United States, with some patients treated on-site and others denied entrance and sent back to their home countries (Kraut, 1994).