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Potential of Fenugreek in Management of Fibrotic Disorders
Published in Dilip Ghosh, Prasad Thakurdesai, Fenugreek, 2022
Amit D. Kandhare, Sunil Bhaskaran, Subhash L. Bodhankar
Trigonelline, a major alkaloid constituent of fenugreek seed, has several pharmacological activities, including anti-fibrotic potential (Zhou, Chan, and Zhou 2012). Fenugreek seed endosperm contains a higher amount of alkaloids (35%), with a primary component of these alkaloids (Jani, Udipi, and Ghugre 2009).
Bioactive Compounds in Coffee: Health Benefits of Macronutrients and Micronutrients
Published in Megh R. Goyal, Durgesh Nandini Chauhan, Assessment of Medicinal Plants for Human Health, 2020
Trigonelline (N-methylnicotinic acid) has hypoglycemic effect in aloxan-treated diabetic rats.12 Trigonelline is an intermediate metabolism of vitamin B3, one of many alkaloids contained raw coffee beans. Trigonelline is a therapeutic coffee compound.1
Diabetes and Phytopharmaceuticals: Translational Pharmacology Perspective
Published in Vikas Kumar, Addepalli Veeranjaneyulu, Herbs for Diabetes and Neurological Disease Management, 2018
Priyanka Ingle-Jadhav, Trupti Rajkumar Angolkar, Ginpreet Kaur
Trigonelline is an alkaloid, possesses hypoglycemic action, present in T. foenum-graecum.35 Galactomannan is a dietary fiber isolated from T. foenum-graceum and it involves in lowering glucose level in type 2 diabetic animals.36
The effects and molecular mechanism of heat stress on spermatogenesis and the mitigation measures
Published in Systems Biology in Reproductive Medicine, 2022
Yuanyuan Gao, Chen Wang, Kaixian Wang, Chaofan He, Ke Hu, Meng Liang
Trigonelline is an alkaloid extracted from coffee beans. Trigonelline is rich in selenium, has anti-radiation effects, and can help the human body use oxygen. To date, there have been numerous reports on the anti-bacterial, anti-cancer, and anti-hyperglycemic effects of trigonelline (Qiu et al. 2020; Choi et al. 2021). Some studies have shown that trigonelline can significantly reduce the production of ROS, for example, the oxygen-glucose deprivation/reperfusion-caused ROS generation and decreased concentrations of SOD and GPX were markedly attenuated by trigonelline (Qiu et al. 2020). Studies have shown that trigonelline can alleviate the oxidative damage induced by intracellular heat stress, and the corresponding dose of trigonelline therapy can reduce oxidative stress and increase the antioxidant capacity of experimental mice (Costa et al. 2020; Lorigooini et al. 2020). It has been shown that trigonelline can relieve the injury induced by heat stress in mice testes. The experimental mice were subjected to heat stress in a 43°C bath, and then given the corresponding dose of trigonelline by intragastric administration. It was concluded that, compared with the control group, the drug intervention group showed an increase in the organ coefficient of reproductive organs and the sperm count of epididymis, improving the response to testicular injury caused by heat stress (Jing et al. 2019). Trigonelline inhibits the NF-KB pathway and decreases the level of superoxide dismutase (SOD), thereby inhibiting the oxidative stress response (Lone et al. 2020; Lorigooini et al. 2020).
A Review on Biosynthesis, Analytical Techniques, and Pharmacological Activities of Trigonelline as a Plant Alkaloid
Published in Journal of Dietary Supplements, 2018
Neda Mohamadi, Fariba Sharififar, Mostafa Pournamdari, Mehdi Ansari
Plants contain several bioactive compounds that have biological effects on a living organisms, tissues, or cells (Chopra et al., 2007). Trigonelline (TRG), a plant alkaloid, was extracted for the first time from the fenugreek seeds (Trigonella foenum-graecum; Fabaceae) (Zia, Hasnain, & Hasan, 2001). It was reported in many other plant species (e.g., Allium sepapea, Pissum sativum, Glycine max, Zea mays, Hordeum vulgare, Lycopersicon esculentum, and Coffea spp.; Fodor & Colasanti, 1985). TRG has been seen in red algae (Tichocarpus crinitus, Botryocladia botryoides, and Pterocladia capillacea; Sciuto, Chillemi, & Piattelli, 1988), in marine sponges such as Calyx nicaensis (nicacensis) and Stryphnusponderosus (Demospongiae), within the Cnidaria (Hydrozoa, Scyphozoa, and Anthozoa; Anthoni et al., 1991), and in mammalians after using nicotinic acid (Shibata & Taguchi, 1987).
Anti-Inflammatory Subfractions Separated from Acidified Chloroform Fraction of Fenugreek Seeds (Trigonella foenum-graecum L.)
Published in Journal of Dietary Supplements, 2018
Mostafa Pournamdari, Ali Mandegary, Fariba Sharififar, Ghazaleh Zarei, Rahele Zareshahi, Amir Asadi, Mohammad Mehdipour
Trigonelline as the main alkaloid of fenugreek seeds was used for standardization of the plan. At first, the absorption spectrum of a stock solution from trigonelline (50 ppm) was recorded and its λmax (the wavelength at which the extract exhibits maximum absorbance) was determined in water by scanning the fresh solution between 200 and 400 nm. For depiction of the standard curve, several concentrations (5, 10, 20, 40, 80 µg/ml) of trigonelline were prepared in distilled water, and absorbance of each sample was measured at λmax (265.5 nm). Different concentrations of fenugreek extract were prepared in distilled water (10, 15, 20, 40, 60, 80, 100 μg/ml). The absorbance of each sample was measured at 265.5 nm. The experiment was done in triplicate and the results were reported as mean ± standard deviation (SD).