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Fenugreek in Management of Immunological, Infectious, and Malignant Disorders
Published in Dilip Ghosh, Prasad Thakurdesai, Fenugreek, 2022
Rohini Pujari, Prasad Thakurdesai
The limitation of synthetic anti-arthritic drugs, such as side effects, led the researchers to investigate natural anti-inflammatory alternatives (Choudhary et al. 2015). Fenugreek is a dietary spice ingredient traditionally used to treat inflammation (Baliga et al. 2015). Furthermore, fenugreek containing Ayurvedic formulation was reported to have anti-arthritic efficacy during randomized placebo-controlled clinical studies (Almuhareb et al. 2019; Chopra, Saluja, and Tillu 2010).
Gestational Weight Gain and Postpartum Obesity
Published in Priyanka Bhatt, Maryam Sadat Miraghajani, Sarvadaman Pathak, Yashwant Pathak, Nutraceuticals for Prenatal, Maternal and Offspring’s Nutritional Health, 2019
Trigonella foenum-graecum, commonly referred to as fenugreek, is an erect annual herb from the soy family that originated from India and North Africa. [46, 47] This has been used as a galactogogue historically, the reason being that it contains significant levels of phytoestrogens. Diosgenin is a phytoestrogen that is believed to be responsible for an increase in milk flow. [42] Habitually, fenugreek tea is prepared by brewing the seeds in boiling water for 20 minutes and it is consumed. This ingredient is also an excellent weight loss supplement, as fenugreek seeds contain saponins and alkaloids as well as soluble dietary fibers, which help increase the feeling of satiety, reducing the wish to eat throughout the day. [46] These seeds have also demonstrated hypoglycemic and hypolipidemic effects in multiple preclinical and clinical studies, as summarized by Parveen Kumar and Uma Bhandari in the review titled “Common medicinal plants with ant obesity potential: A special emphasis on fenugreek.” [48]
Nutraceutical Herbs and Insulin Resistance
Published in Robert E.C. Wildman, Richard S. Bruno, Handbook of Nutraceuticals and Functional Foods, 2019
Giuseppe Derosa, Pamela Maffioli
Fenugreek is a herb that is widely used in cooking and as a traditional medicine for diabetes in Asia. It has been shown to acutely lower PPG levels. Animal studies have shown that fenugreek seed extracts have the potential to slow enzymatic digestion of carbohydrates, reduce gastrointestinal absorption of glucose, and thus reduce post-prandial glucose levels.73 In addition, fenugreek stimulated glucose uptake in peripheral tissues74 and had insulinotropic properties in isolated rat pancreatic cells.75 In humans, fenugreek seeds acutely reduced PPG and insulin levels.76–79 In addition, several longer-term clinical trials showed reductions in FPG and PPG levels and HbA1c.80,81
Effect of cold cabbage leaf application on breast engorgement and pain in the postpartum period: A systematic review and meta-analysis
Published in Health Care for Women International, 2023
Wong et al. (2017) reported that breast engorgement, which was evaluated seven different times, was decreased more in mothers in the cold cabbage leaf group compared to the mothers in the cold gel pack group. In both studies conducted in different years in India (Kumari, 2019; Sharma, 2018), it was determined that cold cabbage leaf application reduced breast engorgement more than application of hot compresses and hot water bags, while the studies conducted in Egypt and India found that hot compress and cold cabbage leaf application reduced breast engorgement equally. The research by Zagloul et al. (2020) was the only study to report that hot compress application reduced breast engorgement more than cold cabbage leaf application. In a study comparing cold cabbage leaf with fenugreek seeds, it was found that fenugreek seeds reduced breast engorgement in a shorter time (Hassan et al., 2020). The researchers, according to the results of these studies indicate that the effect of cold cabbage leaf application on breast engorgement varies, and the combined results did not show a significant reduction in breast engorgement.
Diosgenin inhibits TGF-β1/Smad signaling and regulates epithelial mesenchymal transition in experimental pulmonary fibrosis
Published in Drug and Chemical Toxicology, 2022
Vadivel Dinesh Babu, Anandasadagopan Suresh Kumar, Ganapasam Sudhandiran
Phytochemicals from herbs have gained enormous attention toward treatment as chemotherapeutic agents. Among these phytochemicals Diosgenin, a bioactive steroidal triterpene sapogenin present in the species of Trigonella foenum graecum and Dioscorea villosa, has greatly influenced the ‘drug discovery’ realm as it is a main precursor in progesterone synthesis. Pharmacological features such as anti-inflammatory, androgenic and contraceptive properties are observed in the seeds and leaves of fenugreek (Premanath et al.2011). Over the past few years, growing body of evidences suggests that diosgenin possesses anti-inflammatory (Gao et al.2013), anti-atherosclerosis (Liu et al.2012), hypoglycemic and anti-cancer properties (Mao et al.2012, He et al.2014, Jiang et al.2016). Accumulating evidences indicate that diosgenin inhibits hepatic and renal fibrosis (Wang et al.2014, Xie et al.2015). However, there is lack of evidence against BLM induced pulmonary fibrosis which mimics human fibrosis. Therefore, in the present study, the fibro-protective effect of diosgenin against experimental pulmonary fibrosis in in vivo and in vitro is studied.
Blocking of gastric acid induced histopathological alterations, enhancing of DNA content and proliferation of goblet cells in the acute lung injury mice models by nano-fenugreek oral administration
Published in Toxicology Mechanisms and Methods, 2020
Sherin Ramadan Hamad, Mehrez E. El-Naggar
From last years, researchers have used natural products to treat/prevent various diseases. Recently, researches also go in synthesizing nanoparticles from various natural products (Bharali et al. 2011). Nanomaterial is a particle of size ranging between 1 nm and 100 nm as recorded by many studies (Auffan et al. 2009). Nanoparticles forms have high capability to manipulate particles in order to target specific areas of the body and control the release of drugs (Watkins et al. 2015). Fenugreek (Trigonella foenum graecum) seeds, one of the herbal medicines in the world, which used for tonic, carminative, aphrodisiac effects (Xue et al. 2007) and widely used as spice in food preparations in India, China, Middle East, Egypt, Ethiopia and in oriental countries due to their strong flavor and aroma (Kaviarasan et al. 2007; Ghedira et al. 2010). It also stimulates appetite and activates lung, breathing and lung secretion as well as used as clearance the voice and stimulates menstruation (Azam Khan and Azam 2004; Alavi Khorasani 2018). Fenugreek dose has a wide range. In one human study, daily 25 g of powder from fenugreek seed was good tolerated and no serious side effects (Vijayakumar and Bhat 2008).