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Mitigation of Obesity: A Phytotherapeutic Approach
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
A.B. Sharangi, Suddhasuchi Das
Peanut is a legume or “bean” belonging to the Fabaceae family and free from transfats. Germinated peanut contains lots of resveratrol in addition to polyphenols, isoflavones, and essential amino acids. Peanut sprout extract has anti-obesity potential by reducing the PPARγ expressions which in turn regulates expression of adiponectin (Kang et al., 2014). So, it reduces body weight gain, liver triglyceride content and liver size in addition to increased fecal lipid excretion, suggesting an inhibitory mechanism on lipid absorption (Ranjbar et al., 2012).
Natural Products from the Amazon Region as Potential Antimicrobials
Published in Mahendra Rai, Chistiane M. Feitosa, Eco-Friendly Biobased Products Used in Microbial Diseases, 2022
Josiane E. A. Silva, Iasmin L. D. Paranatinga, Elaine C. P. Oliveira, Silvia K. S. Escher, Ananda S. Antonio, Leandro S. Nascimento, Patricia P. Orlandi, Valdir F. Veiga-Júnior
In the Fabaceae family, several species stand out for their traditional medicinal use and in treatment of parasitic diseases. In the Copaifera genus, not only are the extracts of the bark and leaves used, but also the oleoresins exudated from the trunk. Endemic species, such as C. langsdorffii, C. officinalis, C. reticulata and C. multijuga can exude more than 30 litres of resin, sought by animals to heal their wounds. The popular use of these resins includes healing, anti-inflammatory, antiseptic and anti-tumor activities, and as an agent to treat bronchitis, skin diseases, leishmaniasis, dermatoses and ulcers. “Barbatimão”, Stryphnodendron adstringens, is another legume with traditional use for the treatment of wounds. Its most frequent use, as the name implies, is as an astringent, with these pharmacological actions confirmed scientifically, mainly due to its tannins (Leandro et al. 2012; Cavalcante et al. 2017; Ricardo et al. 2018; Mauro et al. 2019).
Phytochemicals from Wild Medicinal and Aromatic Plants of Argentina
Published in Mahendra Rai, Shandesh Bhattarai, Chistiane M. Feitosa, Wild Plants, 2020
María Paula Zunino, Andrés Ponce, Alejandra Omarini, Julio Alberto Zygadlo
The main phytochemical compounds studied from medicinal plants were essential oils, flavonoids, phenolic acids, and phenols. In some groups, such as Solanaceae or Apocynaceae, the emphasis was placed on nitrogenated compounds, such as alkaloids and its derivatives. The most popular medicinal plants used in traditional medicine by aboriginal communities, to treat the signs or symptoms of ailments related to microbial infection, are Asteraceae, Fabaceae, Polygonaceae, Solanaceae, and Euphorbiaceae. However, 85% of the extracts did not show activity against Candida spp., or dermatophytes (Cordisco et al. 2019).
The kidney antifibrotic effects of 5,7,3′,4′,5′-pentamethoxyflavone from Bauhinia championii in streptozotocin-induced diabetic rats: in vivo and in vitro experiments
Published in Pharmaceutical Biology, 2023
Jialin Li, Xiaocui Huang, Kailun He, Suzhen Wu
Traditional herbal medicine has been used for intractable and chronic diseases for thousands of years (Adam et al. 2016; de Moura Barbosa et al. 2018). Multiple studies have shown that flavonoids, as natural products from herbal medicine had few side effects. (Hashem et al. 2016; Li et al. 2019; Yaribeygi et al. 2019; Wei et al. 2021). Bauhinia championii Benth. (Fabaceae) is a folk medicine used for the treatment of rheumatoid arthritis, and its main active ingredient is flavonoids (Zheng et al. 2013; Aung et al. 2016; Chen et al. 2020). It has been found to alleviate collagen-induced arthritis in rats by inhibiting the TLR4/NF-κB signaling pathway (Xu et al. 2013). DM is also an inflammatory-related disease, and many traditional hypoglycemic herbs are also found to have anti-inflammatory effects (Xie and Du 2011). It is reported that B. championii could alleviate inflammation in the collagen-induced arthritis rat model (Xu et al. 2013, 2016a, 2016b). Flavones from B. championii could alleviate myocardial ischemia/reperfusion injury via antioxidant, anti-apoptotic and anti-inflammatory effects (Jian et al. 2016). However, it is unknown if B. championii can exert kidney protective effects on diabetic rats.
Pharmacokinetic study on the co-administration of abemaciclib and astragaloside IV in rats
Published in Pharmaceutical Biology, 2022
Sen Sun, Lu Liu, Hongming Song, Hong Li
Traditional Chinese medicine has been widely used in clinic, especially in China. Except for cancer patients, some people received herbal treatments for anticancer therapy also increase the possibility of drug-drug interactions (Qi et al. 2015; Wang et al. 2020). Astragalus membranaeus (Fisch.) Bge. (Fabaceae) is a Chinese traditional medicinal plant with various pharmacological functions and has been used in the clinical treatment of breast cancer (Fu et al. 2014; Dong et al. 2022). As one of the most active ingredients of astragalus, astragaloside IV has been reported to suppress metastasis and tumour progression and enhanced the chemosensitivity of breast cancer (Jiang et al. 2017; Zheng et al. 2019; Hu et al. 2021). It is prescribed to breast cancer patients who received therapy of abemaciclib and influenced the pharmacokinetics and pharmacology of abemaciclib.
Pharmacokinetic study on the interaction between pachymic acid and bavachin and its potential mechanism
Published in Pharmaceutical Biology, 2021
Jie Zhang, Lu Liu, Hong Li, Bin Zhang
In the clinic, traditional Chinese medicine has been considered as an important source for the anticancer agent and has been currently used in practice (Feng et al. 2011). Poria cocos (Schw.) Wolf (Polyporaceae) is a well-known traditional Chinese medicine, with a variety of pharmacological effects (Zhang et al. 2018). Pachymic acid is one of the major natural compounds of P. cocos, which has been demonstrated to possess the effects of immunomodulatory, antitumor, anti-inflammation, and antioxidation (Kim et al. 2013; Lee et al. 2013; Zhang et al. 2017). Previous studies have reported that pachymic acid could inhibit cell growth and induce cell apoptosis of lung cancer, which makes it frequently applied in the clinical prescription for lung cancer (Ling et al. 2010; Ma et al. 2015). In the therapy of lung cancer, Psoralea corylifolia Linn. (Fabaceae) is also a commonly used herbal medicine, which can inhibit cell activity of lung cancer (Yin et al. 2019). Bavachin is the main flavonoid in P. corylifolia that has been reported to have antibacterial, anti-inflammation, and antidiabetic activities (Yin et al. 2004; Alam et al. 2018; Hung et al. 2019).