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Medicinal Plants of the Trans-Himalayas
Published in Raymond Cooper, Jeffrey John Deakin, Natural Products of Silk Road Plants, 2020
Ajay Sharma, Garima Bhardwaj, Pushpender Bhardwaj, Damanjit Singh Cannoo
Sea Buckthorn is a well-known plant in folk medicine applied to relieve stomach problems, diarrhea, and coughs and also to treat coronary heart disease and tracheitis (Zheng et al., 2009). Quercetin, kaempferol, isorhamnetin, myricetin, and gallic acid have been isolated from a methanol extract of the leaves (Cumbalov et al., 1976). Isorhamnetin and kaempferol 3-O-β-d-glucoside have also been recorded in the leaves (Rasputina et al., 1976). Quercetin 3-β-d-glucopyranoside, isorhamnetin 3-β-d-glucofuranoside-6-β-d-glucopyranoside, and quercetin 3-galactoglucosides have been isolated from a methanol extract by using column chromatography and paper chromatography (Muxamedyarova and Cumbalov, 1977). Five carotenoids, viz. α-, β-carotenes, lycopene, poly-cis-lycopene, and zeaxanthin, were determined from a hexane extract of H. rhamnoides. Sitosterin was also isolated from unsaponified fractions of the hexane extract (Novruzov, 1981). Kim et al. (2010, 7) reported kaempferol-3-O-β-D-(6″-O-coumaroyl) glycoside, 1-feruloyl-β-D-glucopyranoside, isorhamnetin-3-O-glucoside, quercetin 3-O-β-D-glucopyranoside, quercetin 3-O-β-D-glucopyranosyl-7-O-R-L-rhamnopyranoside, and isorhamnetin-3-O-rutinoside in leaf extracts. Hyperin, tiliroside, 1,2,6-tri-O-galloyl-β-D-glucase, pedunculagin, casuarictin, strictinin, tellimagrandin I, isostrictinin, and casuarinin were isolated from an ethyl acetate fraction, whereas stachyurin, castalagin, and vescalagin were isolated from the water-soluble portion of leaves of H. rhnmnoides (Yoshida et al., 1991). Hipporhamnin, strictinin, and isostrictinin were the reported tannins in the leaves (Sheichenko et al., 1987). Carotenoids, vitamins B, C, and E, riboflavin, and folic acid are present (Suleyman et al., 2001). Zu et al. (2006) have estimated through HPLC that the leaves contain five flavonoids, viz. catechin, rutin, quercetin, kaempferol, and isorhamnetin.
Inhibition of protein phosphatase-1 and -2A by ellagitannins: structure-inhibitory potency relationships and influences on cellular systems
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Zoltán Kónya, Bálint Bécsi, Andrea Kiss, Dániel Horváth, Mária Raics, Katalin E. Kövér, Beáta Lontay, Ferenc Erdődi
Previous results provided data for the effects of tellimagrandin I on cells and revealed that differentiation of human leukemic K562 cells26 and gap junctional communication of HeLa cells were influenced by this polyphenol27. However, no attempts were made to relate these effects to changes in phosphatase activities. We tested first the effect of tellimagrandin I and mahtabin A on the survival and on the phosphatase activity of HeLa cells. Tellimagrandin I suppressed the viability of HeLa cells dramatically in 5–50 µM concentration range after 24 h incubation (Figure 4(A)). Tellimagrandin I partially reduced the phosphatase activity of HeLa cells (after 1 h incubation) in a concentration dependent manner and the effective concentration range was 10–50 µM (Figure 4(B)). These data may suggest that phosphatase inhibition by tellimagrandin I contributes to the initiation of cell death of HeLa cells, however, the different time courses of the viability and phosphatase assays as well as the lack of revealing more detailed molecular background make this conclusion elusive. Quite surprisingly mahtabin A, which is similar in structure to tellimagrandin I and it is also among the potent ellagitannin inhibitors of PP1 (Table 1), was without effect on either the survival or the phosphatase activity of HeLa cells (Figure 4(A,B)).