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Nutrition Part I
Published in Mark C Houston, The Truth About Heart Disease, 2023
Nuts are high in MUFA and PUFA but may also contain some omega-6 FA. The beneficial effects of nut consumption on cardiovascular disease, CV deaths, CHD, and MI was well documented in the PREDIMED trial with a reduction in total CV death of 28% with nut consumption (15–18). In the Adventist Health Study, which examined obesity and metabolic syndrome in more than 800 people, there was a strong inverse relationship between tree nut consumption and developing both medical conditions (169). Other studies suggest that eating tree nuts does not lead to weight gain, and the high concentration of fiber and nutrients offsets the calories consumed. Nuts may reduce CHD deaths and all-cause mortality as well (15–18,170). In a larger analysis of the Adventist Health Study examining death in residents over age 84 and consuming nuts >5 times a week, there was a 20% reduction in total mortality and a 40% reduction in CHD mortality (170). The impact of including nuts in the diet has been analyzed in a recent large meta-analysis (171). The habit of eating 28 grams of nuts/day reduced the risk for CHD by 29%. It was estimated that 4 million deaths a year could be avoided worldwide by eating a handful of nuts daily (172). In a study of 40 subjects comparing a walnut-enriched diet to a control diet over eight weeks, the walnut diet reduced total cholesterol and apolipoprotein B, which is the carrier in the blood for LDL cholesterol (173). Walnuts also significantly improve endothelial function (174).
Plant Source Foods
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
The consumption of walnuts (Figure 5.4) may be related to the reduction of cardiovascular risk both by improvement in lipid profile and reduction of inflammatory and atherogenic processes which are due to the high concentration of antioxidants present in walnuts, such as α-linolenic acid and alpha-tocopherol (163).
Healthy Cooking Techniques
Published in Nicole M. Farmer, Andres Victor Ardisson Korat, Cooking for Health and Disease Prevention, 2022
Joel J. Schaefer, Mary Schaefer
Food selection and preparation must take into account our individual needs. For instance, foods that may prevent the onset of chronic diseases for one person may harm or even kill someone with a severe allergy. Walnuts are a healthy nut, containing a large amount of polyunsaturated fats, which includes omega-3 fatty acids that reduce inflammation. While they are healthy for some, they are also high in phosphorus which doesn’t make them a good choice for someone with chronic kidney disease, and they can be fatally harmful to someone with a severe tree nut allergy.
Walnut intake, cognitive outcomes and risk factors: a systematic review and meta-analysis
Published in Annals of Medicine, 2021
Danielle Cahoon, Shruti P. Shertukde, Esther E. Avendano, Jirayu Tanprasertsuk, Tammy M. Scott, Elizabeth J. Johnson, Mei Chung, Nanguneri Nirmala
Previous systematic reviews and meta-analyses did not show an effect of dietary walnut intake on blood pressure [71,74], or oxidative stress [74]. However, the meta-analysis by Guasch-Ferré et al. [74] found that walnut consumption resulted in significantly higher reduction of total cholesterol, LDL cholesterol, triglycerides, ApoA, and ApoB. Two previous meta-analyses also showed an association between walnut intake and endothelial function, although the effect-size was small and there was no dose-response curve [21,72]. Given the link between damage to brain vasculature and cognitive decline, vascular dementia, and Alzheimer’s disease [75–77] there are plausible biological mechanisms by which incorporating walnuts into a regular diet can promote cognitive health. Our review of risk factors for cognitive decline suggests that walnuts may promote cognitive health by targeting cardiovascular mechanisms, specifically dyslipidemia, rather than other metabolic disturbances. However, additional studies are necessary to investigate the mechanistic role of walnuts on cognition.
Therapeutic effects of walnut oil on the animal model of multiple sclerosis
Published in Nutritional Neuroscience, 2019
Ali Ganji, Iman Farahani, Mohammad Reza Palizvan, Ali Ghazavi, Mostafa Ejtehadifar, Mohsen Ebrahimimonfared, Mana Shojapour, Ghasem Mosayebi
In this way, walnut is a supplement with anti-inflammatory effects that also improves circulation, inhibits heart attacks, prevents eczema, and stabilizes hormones.13 Although walnut trees originated in Asia, they have also been cultivated in Europe.14 Walnut oil contains unsaturated fatty acids and is highly enriched in omega-6 and omega-3 fatty acids, tocopherols, sterols, triterpenes, aliphatic alcohol, proteins, fibre, vitamin E, magnesium, potassium, and copper, all of which have antioxidant and anti-inflammatory activities. These features make walnut oil effective in the treatment of many inflammatory and metabolic diseases, including cardiovascular disease and diabetes.15 Furthermore, the impacts of walnut oil in the improvement of rheumatoid arthritis and the reduction of brain inflammation have been confirmed.16,17
Application of liquisolid technology for promoting the renoprotective efficacy of walnut extracts in chronic renal failure rat model
Published in Drug Development and Industrial Pharmacy, 2019
Sahar Youssef Al-Okbi, Doha Abdou Mohamed, Thanaa El-Sayed Hamed, Sameh Hosam Abd El-Alim, Ahmed Alaa Kassem, Dina Mahmoud Mostafa
Walnut (Juglans regia L., family Juglandaceae) is a popular food around the world. It is rich in bioactive constituents that could be utilized as nutraceuticals for the protection and use as complementary medicine in different chronic diseases. The nonpolar extract of walnut was reported to contain tocopherols, unsaturated fatty acids and phytosterols [5–7]. It contains oleic acid (C18:1), a monounsaturated fatty acid, linoleic acid (C18:2) as omega-6 fatty acid and linolenic acid (C18:3) as omega-3 fatty acid. It also contains campesterol, stigmasterol and beta-sitosterols. The polar extract is rich in phenolic compounds, the main of which is pedunculagin, an ellagitannin [5,7]. Walnut bioactive constituents were demonstrated to possess anti-inflammatory and antioxidant activities [5,7]. Potential health role of walnut on initiation and progression of cardiovascular disease, cancer, and neurodegenerative diseases were reported [5,6,8]. Walnut oil, when used in combination with other plant food extracts, has therapeutic role in adjuvant arthritis in rats [9]. In a previous work, a mixture of both the alcohol i.e. polar, and petroleum ether i.e. non polar extracts of walnut showed high safety and proved to have renoprotective effect in rat model of cisplatin induced renal dysfunction when applied at a dose level of 250 mg/kg rat body weight [7]. This dose level equals 2800 mg for 70 kg human when changing the dose from rat to human according to Paget & Barnes [10]. In spite of the health benefits of walnut extracts, the poor water solubility and incomplete absorption of its constituents leads to diminished biological effects.