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Role of Bacteria in Dermatological Infections
Published in K. Balamurugan, U. Prithika, Pocket Guide to Bacterial Infections, 2019
Thirukannamangai Krishnan Swetha, Shunmugiah Karutha Pandian
In addition, the novel lantibiotics synthesized by commensal coagulase negative Staphylococcus spp. were found to synergize with cathilicidin (a cationic antimicrobial peptide), which curtails the growth of S. aureus (Nakatsuji et al., 2017). However, S. aureus evade the attack of host cationic antimicrobial peptides (CAMP) by modulating its cell surface charge, which is actively accomplished by Dlt protein and MprF enzyme that neutralize the negative charge of cell wall surface by substituting D-alanine in cell wall teichoic and lipoteichoic acids, and adding L-lysine to phosphatidyl glycerol, respectively (Cogen et al., 2008). Besides, staphyloxanthin, a golden-colored carotenoid pigment produced by S. aureus, protects it from oxidants and neutrophilic attack by exhibiting antioxidant activity (Sethupathy et al., 2017).
Synthesis and biological evaluation of thiazolidinedione derivatives with high ligand efficiency to P. aeruginosa PhzS
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Thamires Quadros Froes, Bianca Trindade Chaves, Marina Sena Mendes, Rafael Matos Ximenes, Ivanildo Mangueira da Silva, Priscila Brandão Gomes da Silva, Julianna Ferreira Cavalcanti de Albuquerque, Marcelo Santos Castilho
The development of novel antibiotic drugs continues to be of utmost importance61,62. However, the research and development of novel antibiotic drugs by the Big-Pharma industries has steadily declined in the last decades63,64. There are some promising alternatives to deal with this issue65,66. Among them, anti-virulence drug development relies on the hypothesis that is better to “live in peace with the enemy” than to kill it67. One way to achieve this goal is by rendering the pathogenic bacteria harmless to the human host and assuming this process will put less evolutive pressure on the microorganism than the currently available drugs67–70. Much effort has been put into the inhibition of pigmented virulence factors such as staphyloxanthin and pyocyanin71,72 but the approach is taken to their modulation is rather distinct. The first relies on the inhibition of druggable targets that are responsible for staphyloxanthin biosynthesis,73,74 whereas the second is focussed on the modulation of quorum sensing mechanisms that lie upstream the biosynthetic pathway that builds up this virulence factor75–78.