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Community-Based Methods for Preventing Dental Caries and Periodontal Disease
Published in Lars Granath, William D. McHugh, Systematized Prevention of Oral Disease: Theory and Practice, 2019
The American Dental Association currently accepts Crest, Aim, Macleans, Colgate with MFP, and Aquafresh as therapeutic fluoride dentifrices. The first two contain sodium fluoride as the active ingredient, the last three use sodium monofluorophosphate. All contain about the same concentration of fluoride (1000 to 1100 ppm F); an adult toothbrush-load of such a toothpaste contains about 1 mg F. A number of other formulations are available in various countries, some using stannous fluoride and others using amine fluoride as the active ingredient.
Nano-hydroxyapatite use in dentistry: a systematic review
Published in Drug Metabolism Reviews, 2020
Ioana Roxana Bordea, Sebastian Candrea, Gabriela Teodora Alexescu, Simion Bran, Mihaela Băciuț, Grigore Băciuț, Ondine Lucaciu, Cristian Mihail Dinu, Doina Adina Todea
Wang et al. (2016) conducted a 3-month clinical trial that evaluated the hypersensitivity management of nano-HA pastes. They included 28 subjects in this study with 137 teeth that presented a minimal hypersensitivity of 4 on the visual analog scale (VAS). Four groups were formed: desensibilize nano-P paste (20% HA potassium nitrate and NaF, 9000 ppm F), desensibilize nano-P associated with home-care pastes (10% HA, potassium nitrate and NaF, 900 ppm F), Pro-Relief professional paste (8% Arginine) associated with home care tooth paste (8% Arginine, sodium monofluorophosphate, 1450 ppm F) and Duraphat professional varnish (NaF varnish, 22.600 ppm F), respectively. After applying the professional treatment over a 3-week period and the home-care over a 3-month period, statistical analysis could be made with data collected at baseline, at 1 month and 3 months, data consisting in VAS evaluation.
Assessment of cytotoxic and genotoxic effects of conventional and whitening kinds of toothpaste on oral mucosa cells
Published in Acta Odontologica Scandinavica, 2018
Antonija Tadin, Lidia Gavic, Ana Zeravica, Klara Ugrin, Nada Galic, Davor Zeljezic
Other toothpaste components such as sodium monofluorophosphate, silicon dioxide, hydrated silica, sodium benzoate, preservatives, colors, flavors, and essences might also exhibit toxic effects [17,23]. Colgate Whitening toothpaste contains the highest amount of fluoride components (sodium monofluorophosphate 1.1%), which combined with abrasive particles and sodium lauryl sulfate turned this toothpaste to seem least biocompatible. We monitored the effect of the use of this toothpaste over a period of 60 days, but it may be speculated that the micronucleus incidence would fall to referent level with prolonged use. Our results are likely to differ from those obtained by in vitro studies due to numerous factors such as saliva, a mucus layer, creatine levels, blood flow, and oral flora, which can influence the efficiency of epithelial cell protection against harmful materials [6].
Nanoencapsulated fluoride as a remineralization option for dental erosion: an in vitro study
Published in Acta Odontologica Scandinavica, 2021
Juliane Rolim de Lavôr, Nayanna Lana Soares Fernandes, Elizabeth Barreto Galvão de Sousa, Juliellen Luiz da Cunha, Ingrid Andrade Meira, Fábio Correia Sampaio, Andressa Feitosa Bezerra de Oliveira
Dentifrices incorporate arginine in its formulation to act in conjunction with calcium carbonate and fluoride to promote mineral deposition on the exposed surface [36]. Conflicting findings are described in the literature regarding the performance of these components in remineralization/protection of dental erosion [14,28,33–36]. A poor performance was also found in other studies [14,28,35,37], demonstrating that this product acted as a placebo or dentifrice without fluoride. In contrast, Rege et al. [15], Yamashita et al. [38] and Sullivan et al. [39] found a satisfactory remineralizing potential. A layer rich in calcium was observed on the demineralized enamel, in which arginine is believed to modify the enamel surface charge, increasing the affinity of calcium carbonate for the dental surface and filling the microscopic spaces created by the acid, which would lead to enamel recovery and protection of the surface against future erosion challenges [15]. However, this may not guarantee the effective remineralizing action of the toothpaste, since, according to Lussi et al. [10], the calcium carbonate layer is very soluble and has a short life to lead to precipitation of the mineral, which may explain its lack of remineralization performance in the model used. Also, AG has sodium monofluorophosphate in its composition, which needs to be cleaved in the oral environment through phosphatases to release ionic fluoride and act in the remineralization process. Finally, discreet surface microhardness remineralization was presented in the NC group that may have been due to the type of model used, remineralizing, which is characterized by a remineralization > demineralization [40].