China
Africa
Explore chapters and articles related to this topic
Asparagus Sp.: Phytochemicals and Marketed Herbal Formulations
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
Vikas Bajpai, Pratibha Singh, Preeti Chandra, Brijesh Kumar
The quantitation of the major bioactive compounds in different samples of Asparagus species are summarized in Table 12.3. Significant differences in total contents of saponin, sapogenin, flavonoids, and phenolic acids were observed in the three species of Asparagus samples. Saponin, shatavarin-IV was detected highest (12.40 mg/g) in twig of A. adscendens. While sapogenin, sarsasapogenin was found second highest (6.55 mg/g) in roots of A. racemosus. Flavonoids (quercetin, apigenin) raise up to 0.75 mg/g and 0.02 mg/g, respectively. Similarly, among phenolic acids, caffeic acid (3.05 mg/g) was the highest in A. adscendens twig in comparison to ferulic acid (0.67 mg/g) and vanillin (0.30 mg/g), which were analyzed highest in A. racemosus twig. Stem and leaf of A. racemosus were having relatively lower content of bioactive compounds (caffeic acid, 0.24 and 0.03 mg/g; vanillin, 0.17 and 0.12 mg/g, respectively) while some of these compounds were not able to detected in Asparagus species samples.
Preclinical Antidepressant-Like Effects of Terpenes, Polyphenolics, and Other Non-Flavonoid Phytochemicals
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
Sarsasapogenin is a steroidal triterpene that was initially identified in plants of the genus Smilax. That genus includes various sarsaparilla plants, which lends the triterpene its name.194 Sarsasapogenin is also found, even more abundantly, in the Asian plant, Anemarrhena asphodeloides. Anemarrhena is a plant genus in family Asparagaceae. It has only one species, Anemarrhena asphodeloides, which is native to China, Korea, and Mongolia.195 Sarsasapogenin extracted from Anemarrhena asphodeloides is used as a starting point for synthesis of steroids. Anemarrhena asphodeloides itself has long been used in Traditional Chinese Medicine. In Chinese, the name of the herb is zhi mu, and it is commonly used for inflammatory conditions and to treat symptoms of menopause.196 It is also used in the herbal combination zhi bai di huang wan to treat depression-like symptoms in human patients, and suan zao ren tang to treat restlessness and insomnia.197
Research progress of natural products and their derivatives against Alzheimer’s disease
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Jin-Ying Liu, Hong-Yan Guo, Zhe-Shan Quan, Qing-Kun Shen, Hong Cui, Xiaoting Li
Sarsasapogenin is a steroidal sapogenin isolated from the Chinese herbal medicine Anemarrhena. It is similar in structure to diosgenin and has a similar structure-activity relationship. Current studies have shown that sarsasapogenin significantly inhibits key enzymes involved in AD pathogenesis, namely AChE, BuChE, BACE1, and MAO-B77,78, in a concentration-dependent manner. It also inhibits neuroinflammation and Aβ amyloid production79,80. It can exert neuroprotective effects in many ways, thereby improving pathological symptoms. Derivative design has also received considerable attention. Based on the activity of lead compounds, the synthesis of potential AD drugs with stronger activity and minimal side effects has also been extensively studied (Figure 12).
Sarsasapogenin and fluticasone combination improves DNFB induced atopic dermatitis lesions in BALB/c mice
Published in Immunopharmacology and Immunotoxicology, 2021
Deepa S. Mandlik, Satish K. Mandlik, Snehal S. Patel
Sarsasapogenin (Figure 1) is a steroidal sapogenin found in numerous Smilax species, including Smilax china, Smilax officinalis, Smilax aspera, Smilax ornata, Smilax febrifuga and Smilax aristolochiifolia [23]. It is also present in the Anemarrhena asphodeloides rhizome that is utilized in Chinese traditional medicine. Also used as a starting product for the development of steroidal hormones. It has a wide range of pharmacological properties, including anti-depressant and anti-tumor properties. SG improves memory by raising the number of acetylcholine receptors in the brains of the memory-deficient model in the rat [24]. The anti-inflammatory function of SG obtained from S. officinalis is equivalent to that of traditional anti-inflammatory drugs such as dexamethasone [25]. Psoriasis, arthritis, and rheumatism are also treated with SG [26–28]. The effect of SG has also been evaluated in rats in the early stages of diabetic nephropathy [29]. Ingawale et al. [30] have studied the effect of combining SG and FC in ovalbumin convinced bronchial asthma in a mice model [30].
Combination of Sarsasapogenin and Fluticasone attenuates ovalbumin-induced airway inflammation in a mouse asthma model
Published in Immunopharmacology and Immunotoxicology, 2020
Deepa K. Ingawale, Satish K. Mandlik, Snehal S. Patel
Sarsasapogenin (SG) (Figure 1) is a steroidal sapogenin obtained from many smilax species such as Smilax ornata, S. aspera, S. febrifuga, S. china, S. aristolochiifolia, and S. officinalis belonging to the family Smilacaceae [12]. It is also found in the rhizome of Anemarrhena asphodeloides, which is used in Chinese traditional medicine. It is used as a preliminary material for the synthesis of steroids. It shows numerous pharmacological activities, such as antitumor and anti-depressant activities. Hu et al. [13] have studied the memory-enhancing activity of SG by increasing the concentration of muscarinic acetylcholinergic receptor in the brains of memory-deficit rat models. SG obtained from S. officinalis has anti-inflammatory activity comparable to conventional anti-inflammatory drugs like dexamethasone [14]. It is also used for the treatment of psoriasis, arthritis and rheumatism [15–17]. Recently, Liu et al. [18] have studied the effects of SG in rats against the early stage of diabetic nephropathy by inhibition of IL‐18, NLRP3 gene, and caspase 1 in renal cortex of diabetic rats. To the other side, different preclinical research studies have shown significant anti-inflammatory and antioxidant effects of SG [19]. However, none of the study has been reported on the probable protective effect of SG in the treatment of OVA-induced allergic asthma inflammation. Glucocorticosteroids (GCs) are the choice of drug for the regular treatment of asthma. However, these drugs are normally associated with major adverse effects. The chronic use of minimum dose of GCs with phytosteroid like SG can be a possible therapeutic substitute for the treatment of asthma patients with fewer side effects.