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Monographs of essential oils that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Salvia officinalis L. is a perennial, evergreen subshrub, up to 60 cm tall, with a woody base, soft gray-green oval leaves and a mass of blue or violet inflorescences (2). The name Salvia comes from the Latin salvere, which means ‘to be well, to be in good health’, indicating the (perceived) medical value of the plant (3). The Dalmatian sage is native to south-eastern Europe (Albania, former Yugoslavia, Greece, Italy) and is now widely cultivated in many (warm)-temperate regions of the world, mainly to obtain dried leaves to be used as a raw material in medicine, perfumery, and the food industry (1, 13).
An Introduction to the Ethnopharmacology of Wild Plants
Published in Mahendra Rai, Shandesh Bhattarai, Chistiane M. Feitosa, Ethnopharmacology of Wild Plants, 2021
Shandesh Bhattarai, Christiane Mendes Feitosa, Mahendra Rai
Croton lechleri is an herb used in folk medicine as an anti-inflammatory, antimicrobial and anticancer properties (Hartwell 1969, Pieters et al. 1993, Lopes et al. 2004). Crude extracts from plants like Colubrina macrocarpa, Hemiangium excelsum, and Acacia pennatula possess a selective cytotoxic activity against human tumor cells (Popoca et al. 1998). In the Palestinian and Israeli territories, extracts of Teucrium polium and Pistacia lentiscus are known to treat liver disease, jaundice, diabetes, fertility problems and cancer (Howiriny and Sohaibani 2005). Paris polyphylla has been used to treat liver cancer and has been reported as a potent anticancer agent. Salvia officinalis are known for their antitumor effects (Liu et al. 2000), and Solanum nigrum to cure inflammation, edema, mastitis and hepatic cancer (Lee and Lim 2003). Until the development of penicillin in the early 1940s, most natural product-derived drugs were obtained from terrestrial plants. The success of penicillin in treating infection led to an expansion in the area of drug discovery from microorganisms. Unlike the long-standing historical medical uses of terrestrial plants, marine organisms have a shorter history of utilization in the treatment of human disease (Dewick 2002, Newman et al. 2003, Butler 2005, Sneader 2005).
Phytotherapeutic Potential For the Treatment of Alzheimer’s Disease
Published in Atanu Bhattacharjee, Akula Ramakrishna, Magisetty Obulesu, Phytomedicine and Alzheimer’s Disease, 2020
Muhammad Akram, Atanu Bhattacharjee, Naveed Munir, Naheed Akhter, Fozia Anjum, Abida Parveen, Samreen Gul Khan, Muhammad Daniyal, Muhammad Riaz, Fahad Said Khan, Rumaisa Ansari, Umme Laila
An important active component of Salvia officinalis is rosmarinic acid, which has a number of important features, like antioxidant effects, preventing peroxidation of lipids. Patients treated with rosmarinic acid for sixteen weeks showed improvements in their health (Tian, Shi et al. 2010).
Neuroprotective role of medicinal plant extracts evaluated in a scopolamine-induced rat model of Alzheimer's disease
Published in Biomarkers, 2022
Asmaa K. Abdelghany, El-Shymaa El-Nahass, Marwa A. Ibrahim, Akram. M. El-Kashlan, H.H. Emeash, Fatma Khalil
The 90 rats were randomly allocated into six groups of 15 animals: (i) control, receiving intraperitoneal (IP) saline injections; (ii) SCO -treated group, receiving IP injection of scopolamine hydrobromide trihydrate in saline solution, at a dose of 2.2 mg/kg (Bihaqi et al.2012; Lee et al., 2014; Hafez et al., 2017); (iii) NS-treated group, receiving SCO-treatment plus per os (PO) administration of ethanolic extract of nigella sativa at a dose of 400 mg/kg (Hosseini et al., 2015); (iv) RO-treated group, receiving SCO-treatment plus ethanolic extract of Rosmarinus officinalis (200 mg/kg, PO) (Ozarowski et al., 2013); (v) SO-treated group, receiving SCO-treatment plus ethanolic extract of salvia officinalis (600 mg/kg, PO) (Hasanein et al., 2016); and (vi) GS-treated group, receiving SCO-treatment plus ethanolic extract of ginseng (200 mg/kg, PO) (Lee et al., 2010). All groups received treatments daily for 2 months. In groups (iii-vi), extracts were orally gavaged 90 minutes after SCO injection.
Screening and identification of novel inhibitors against human 4-aminobutyrate-aminotransferase: A computational approach
Published in Egyptian Journal of Basic and Applied Sciences, 2018
S. Vijayakumar, G. Kasthuri, S. Prabhu, P. Manogar, N. Parameswari
Among the 32 ligands, rosmarinic acid had the second valuable docking scores (-8.687). Analysis of the docked complex demonstrates that the residue contacts were Gly298, Leu299, Gln267, Gln231, Asp264 and Tyr16. Fig. 6a shows the residue contacts and their distance values in pink color. Among the seven residue contacts, most of the residues were Gln267 (OH), Glh231 (OH), Asp264 (OH) and Tyr261 (O) formed in hydrogen bond side chain contacts with ligand. Gly298 (OH) and Leu299 (OH) were involved in the hydrogen back chain contacts with rosmarinic acid. Surprisingly, the residue Tyr261 is involved in both side chain as well as the π-π stacking contacts with the ligand (Fig. 6b). Rosmarinic acid is a specific bioactive molecule in the plant species of Salvia officinalis which also contains other medicinal plant species like Prunella vulgaris and Melissa officinalis. It reduces the number of harmful actions in induced by Aβ, which include reactive oxygen species configuration, lipid peroxidation, DNA destruction, caspase-3 establishment and protein hyperphosphorylation [42]. Medicinal plants that contain this molecule have been exploited as an effective neurological activity. Salvia officinalis is treated eleven mild to moderate symptoms having Alzheimer disease patients, there it has significantly improved the cognitive functions [43]. This shows the favorable docking score with the human 4-aminobutyrate aminotransferase target (Table 3).
Salvia officinalis attenuates bleomycin-induced oxidative stress and lung fibrosis in rats
Published in Nutrition and Cancer, 2020
Sana Bahri, Ridha Ben Ali, Afef Nahdi, Mona Mlika, Raed Abdennabi, Saloua Jameleddine
Salvia officinalis is one of the most known medicinal plants in the world. Various research works demonstrated the beneficial effect of this herbal plant in the treatment of several functional disorders of the human body, mainly because of its richness with bioactive compounds. Among the pharmacological properties of Salvia officinalis we can include antitumoral and antiangiogenic activities (11), antioxidant activity (12), anti-inflammatory (13) and anti-nociceptive activities (14,15), antimicrobial activity (16), and antidiabetic activity (17). These findings prove that Salvia officinalis can be a good candidate in the treatment of human pathologies such as fibrosis, where inflammation, oxidative stress and angiogenesis play a central role.