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Can Recurrent Pregnancy Loss Be Prevented by Antithrombotic Agents?
Published in Howard J.A. Carp, Recurrent Pregnancy Loss, 2020
Audrey A. Merriam, Michael J. Paidas
However, the question is whether anticoagulants are warranted in patients with RPL and a thrombophilia. The editor performed a meta-analysis of the figures in Skeith et al.'s [18] meta-analysis for patients with RPL [19–22] and a trial by Aynioglu [23]. The figures are shown in Figure 9.2 of Chapter 9. There was a statistically significant increase in the live birth rate (odds ratio [OR] 4.88; CI 2.82–8.47). However, the OR is dependent on Aynioglu's [23] trial, which is at variance with the other three trials. Hence the need for the use of treatment with prophylactic anticoagulation, either heparin or LMWH, in women with a history of thrombophilia and RPL or second trimester fetal demise, is an open question. It is inappropriate to recommend treatment on the basis of one randomized controlled trial [23], as benefit, defined as successful pregnancy, has not been consistently demonstrated. In addition, anticoagulant medication does carry risk to the patient, even at prophylactic doses. Heparin-induced thrombocytopenia and major bleeding episodes are rare but can occur. More commonly, aversion to daily injections, cost, and potential injection site reactions can be seen. These potential serious and non-serious side effects question the use of anticoagulant medications solely for improved pregnancy outcomes if benefit is not consistent.
Mental health law
Published in Marc Stauch, Kay Wheat, Text, Cases and Materials on Medical Law and Ethics, 2018
Section 23 states: It should be noted that, under s 23, these are powers, and not duties, and therefore a patient cannot claim that, for example, once he ceased to be a danger to self, or others, he should be discharged under s 23.
The Ultrastructure of Olfactory and Nasal Respiratory Epithelium Surfaces
Published in D. V. M. Gerd Reznik, Sherman F. Stinson, Nasal Tumors in Animals and Man, 2017
Table 8 shows that the fraction of P-face particle densities as a percentage of the summated densities of particles in both fracture faces of all structures considered, except for respiratory cilia (see Section VI), fluctuates between 70 and 85%, indicating that the partitioning of particles between fracture faces results from fracturing procedures rather than from the chemical nature of the particles.231 Menco's23 results show that
Social media’s impact on widespread SARMs abuse
Published in The Physician and Sportsmedicine, 2023
Henrik A. Hahamyan, Nikhil Vasireddi, James E. Voos, Jacob G. Calcei
Despite the lack of robust clinical research, safety data, and even reliable purchasing sources, these World Anti-Doping Agency (WADA) prohibited substances have continued to see annual increases in positive test results by means of novel hair, nail, urine, and blood detection methods [9]. Famous SARMs-related doping cases on the professional level, such as Chijindu Ujah (Ostarine and S-23), Joakim Noah (LGD-4033), and the controversial case of Laurence Vincent Lapointe (LGD-4033), have circulated throughout social media bringing further attention to the drugs’ performance enhancing capabilities [10–12]. Broadly, a 2021 online based randomized response technique (RRT) survey found that 2.7% of male gym-goers in the Netherlands have used SARMs specifically [13]. True population prevalence is likely higher as illegal substance use is commonly underreported, so indirect SARMs prevalence measures like wastewater-based epidemiology are being studied [14]. Analysis of social media trends suggests just that, SARMs usage is growing.
Effects of sensory cues on dynamic trunk control in children with spastic diplegic cerebral palsy
Published in Physiotherapy Theory and Practice, 2022
Nalin Khumlee, Duangporn Suriyaamarit, Sujitra Boonyong
In the present study, a seat pressure mat device (Tekscan CONFORMat, Model#5330, Boston, MA, USA) with a specific-designed program (Tekscan CONFORMat research 7.20) was used to measure the CoF trajectory and LOS. The sampling rate used was 15 Hz, with a low-pass filtering noise threshold (< 3 Hz). System calibration was performed with S-23 sensitivity (range 1–40). Each recording was set to 4,500 frames per 300-s (5-min) recording. The CoF trajectory included four directions: 1) forward; 2) backward; 3) left; and 4) right indicating the maximum anterior, posterior, left, and right-leaning movements in centimeters (cm) away from the subject’s center of balance. The LOS (total area encompassed during maximum trunk leaning in the four directions) was represented in square centimeters (cm2).
Assessment of de novo copy-number variations in Italian patients with schizophrenia: Detection of putative mutations involving regulatory enhancer elements
Published in The World Journal of Biological Psychiatry, 2019
Giulio Piluso, Palmiero Monteleone, Silvana Galderisi, Teresa Giugliano, Alessandro Bertolino, Paola Rocca, Alessandro Rossi, Armida Mucci, Eugenio Aguglia, Ileana Andriola, Antonello Bellomo, Anna Comparelli, Francesco Gambi, Andrea Fagiolini, Carlo Marchesi, Rita Roncone, Emilio Sacchetti, Paolo Santonastaso, Alberto Siracusano, Paolo Stratta, Alfonso Tortorella, Luca Steardo, Paola Bucci, Vincenzo Nigro, Mario Maj
One patient (S-23) showed a de novo heterozygous deletion affecting only part of the intron 12 of CNTNAP2. This gene is highly conserved and expressed in different areas of the brain, where it encodes for Caspr2 protein, which has been implicated in neuronal migration (Allen et al. 2011). Mutations in CNTNAP2 have already been described in members of Old Order Amish families presenting a neuropathological phenotype with cortical dysplasia and focal epilepsy, as well as in two other unrelated families with Pitt-Hopkins-like syndrome (Strauss et al. 2006; Wurst and Prakash, 2014). In addition, several studies indicate that CNTNAP2 is an autism susceptibility gene (Alarcón et al. 2008; Zweier et al. 2009). Recently, Friedman et al. (2008) first demonstrated an association between CNTNAP2 and schizophrenia, describing different gene deletions in three unrelated patients with schizophrenia and autism. Like our patient who showed a deletion involving only the intron 12 of CNTNAP2, one of Friedman’s patients had a small deletion of the CNTNAP2 intron 3. The pathogenic significance of these intronic rearrangements remains to be clarified. For patient S-23, the deleted region of intron 12 seems to be enriched in putative transcription factor binding sites conserved in the human/mouse/rat alignment, as well as DNaseI hypersensitivity clusters that could perturb CNTNAP2 expression or act at distance, affecting other genes (http://genome.ucsc.edu).