China
Africa
Explore chapters and articles related to this topic
Migraine
Published in Charles Theisler, Adjuvant Medical Care, 2023
Riboflavin: In a randomized trial in 55 adults with migraine, 400 mg/day riboflavin reduced the frequency of migraine attacks by two per month compared to a placebo.19 In a retrospective study, 41 children (mean age 13 years) in Italy who took 200 or 400 mg/day of riboflavin for three to six months experienced a significant reduction in the frequency and intensity of migraine headaches.20 High doses of riboflavin (vitamin B2) helps prevent migraines and reduce the frequency of headaches.20 For migraine headaches, the most common dose is 400 mg of riboflavin daily for at least three months.
Nutritional Diseases
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Chelsea Kesty, Madeline Hooper, Erin McClure, Emily Chea, Cynthia Bartus
Overview: Riboflavin deficiency is relatively rare, but it can occur in malnourished patients (anorexia nervosa, malignancy, and malabsorptive state, such as celiac disease and short bowel syndrome), long-term users of phenobarbital, and patients with very restricted diets. It may also be found in breastfed infants whose mothers are riboflavin deficient. Symptoms are nonspecific, and riboflavin deficiency is usually accompanied by other coexisting vitamin deficiencies.
Micronutrients
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
The richest natural sources of riboflavin are milk and dairy products (yogurt, cheese), providing 25% or more of total riboflavin intake in most diets (33). Vitamin B2 is also found in foods such as yeast (for instance, brewer’s yeast), soybeans, malted barley, whole grains, wheat germ, brown rice, mushrooms, broccoli, Brussels sprouts, spinach, eggs, liver, kidney, and heart. (3, 9, 33, 37–38). As riboflavin is easily destroyed by light, food should be stored away from light to protect its riboflavin content (33). Riboflavin can withstand heat, so there is no problem when cooking foods containing this vitamin.
Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
Published in Nutritional Neuroscience, 2022
Yu-Shiue Chen, Huan-Fang Lee, Ching-Hsuan Tsai, Yu-Yun Hsu, Ching-Ju Fang, Chen-Ju Chen, Yu-Hsin Hung, Fang-Wen Hu
Migraine has a tendency to be inherited and is associated with mitochondrial dysfunction. Mitochondrial diseases are a group of inherited diseases that are characterized by defects in oxidative phosphorylation and is caused by gene mutations in nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) [31]. Vitamin B2 or riboflavin, as a non-drug nutrient supplement, is a cofactor in the citric acid cycle and redox reaction in the electron transport chain. Therefore, vitamin B2 plays an important role in energy generation in the mitochondria, and vitamin B2 is used as a potential treatment for mitochondrial diseases affecting energy metabolism [32,33]. Vitamin B2 seems to be a safe and well-tolerated option to prevent migraine symptoms in adults; however, there is currently insufficient evidence to recommend vitamin B2 as an adjuvant treatment for adults with migraine [17]. In 2020, the pain care guidelines in the Cochrane Taiwan website recommended daily administration of 400 mg vitamin B2 (riboflavin) for three continuous months to prevent migraine in adults. The GRADE level of evidence was 1A (strong recommendation, high level of evidence) [34].
Two cases of glutaric aciduria type II: how to differentiate from inflammatory myopathies?
Published in Acta Clinica Belgica, 2019
Meltem Koca, Abdulsamet Erden, Berkan Armagan, Alper Sari, Fatih Yildiz, Sevim Ozdamar, Umut Kalyoncu, Omer Karadag
GAII is caused by defects of ETF or ETFDH which are the parts of electron transfer chain. High energy electrons which are produced in the mitochondrial matrix by several acyl-CoA dehydrogenases are transferred to ETF. ETFDH then conducts dehydrogenation to carry electrons to ubiquinone in the respiratory chain. Vitamin B2 (riboflavin) is the co-factor for ETF, ETFDH and acyl-CoA dehydrogenases. Therefrom in case there is a defect in ETF or ETFDH, all acyl-CoA dehydrogenases in beta oxidation of fatty acids are affected [15,16]. Riboflavin supplementation dramatically improves clinical symptoms in a group of GAII patients. There is an association with riboflavin responsiveness and having ETFDH mutations and these patients are usually those with late-onset form [17]. Knowing that GAII may cause secondary carnitine and CoQ 10 deficiency, supplementation of CoQ 10 and carnitine can be added to treatment regimen [11,17]. In the first case, CoQ 10 and carnitine were added to treatment with this point of view. The patient in the second case whose muscle weakness was less severe at presentation, improved with riboflavin plus carnitine, and her muscle strength returned to normal.
Effect of Phoenix dactylifera L. Sap Against Bleomycin-Induced Pulmonary Fibrosis and Oxidative Stress in Rats: Phytochemical and Therapeutic Assessment
Published in Nutrition and Cancer, 2019
Sana Bahri, Raed Abdennabi, Mona Mlika, Gharsallah Neji, Saloua Jameleddine, Ridha Ben Ali
In addition, niacin or vitamin B3 was reported earlier to inhibit the expression of procollagen I and procollagen III genes (30) and the synthesis of transforming growth factor β (TGF-β) protein (31) in the BLM model of pulmonary fibrosis when associated with taurine. These effects are demonstrated with a decrease in lung hydroxyproline content in rats (32). Riboflavin is also an essential component of coenzymes involved in multiple cellular metabolic pathways, including the energy-producing respiratory pathways (33). It has been reported earlier that patient with cystic fibrosis has an occurrence in riboflavin (34). In our case, we detected a high amount of riboflavin in the DPS from the Ameri variety, which may attenuate the high level of hydroxyproline and counteract the deleterious effects induced by BLM in rat lung. Finally, thiamin was reported to prevent obesity and metabolic disorders (35) and to reverse ethanol-induced hepatic and neuronal damage in rats (36) by its antioxidant properties. Together, all these findings suggest that these vitamins found in DPS can probably converge to play an anti-fibrotic and antioxidant role in the BLM model of pulmonary fibrosis.