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The Treatment of Hypertension with Nutrition, Nutritional Supplements, Lifestyle and Pharmacologic Therapies
Published in Stephen T. Sinatra, Mark C. Houston, Nutritional and Integrative Strategies in Cardiovascular Medicine, 2022
Pomegranate (Punica granatum L.) reduces serum ACE activity by 36%, improves endothelial function, lowers BP and reduces carotid IMT [2–4,231–234]. A meta-analysis from 8 RCTs showed significant reductions in both SBP (4.96 mmHg − p < 0.001) and DBP (p = 0.021) after 6 oz of pomegranate juice consumption [231].
Biblical times
Published in Michael J. O’Dowd, The History of Medications for Women, 2020
The pomegranate (Punica granatum) is an Oriental fruit much cultivated in warm countries. It takes its name from the Latin pomum, apple, and granatum, having many grains or seeds. ‘Punic’ refers to ancient Carthage (Latin punicus or poeni, the Carthaginians) and the ‘Punic apple’ was the pomegranate. The first reference to pomegranate in the Bible is found in Exodus 28: 33–34: A golden bell [a pomegranate flower] and a pomegranate, upon the hem of the robe round about’. The Lord here commanded Moses that the skirts of the priestly robes, or ephods, should be embroidered in blue, purple and scarlet in imitation of the flowers and fruit of the pomegranate. In The Song of Solomon there are a number of references to the pomegranate, one of which relates to the perceived aphrodisiac qualities of the plant: ‘How beautiful you are my love ... let us [see] ... whether the pomegranates are come into flower; there will I give you my love’ (7: 6–12).
Natural Products as Economical Agents for Antioxidant Activity
Published in Hafiz Ansar Rasul Suleria, Megh R. Goyal, Masood Sadiq Butt, Phytochemicals from Medicinal Plants, 2019
Nida Nazar, Abdullah Ijaz Hussain, Syed Makhdoom Hussain, Poonam Singh Nigam
Some tropical fruits have also been studied for their antioxidant properties, such as mangosteen (Garcinia mangostana), guava (Psidium guajava), papaya (Carica papaya L.), dragon fruit (Hylocereus undatus), and star fruit (Averrhoa carambola), as well as banana (Musa sapientum) and water apple (Syzygium aqueum) that are well known for their antioxidant properties.92 Pomegranate (Punica granatum L.) has been widely used in medicine for a number of therapeutic reasons due to its high antioxidant capacity.39,106
Antimicrobial activity of denture adhesive associated with Equisetum giganteum- and Punica granatum-enriched fractions against Candida albicans biofilms on acrylic resin surfaces
Published in Biofouling, 2018
Nara Ligia Martins Almeida, Luiz Leonardo Saldanha, Rafaela Alves da Silva, Karen Henriette Pinke, Eliane Ferraz da Costa, Vinicius Carvalho Porto, Anne Lígia Dokkedal, Vanessa Soares Lara
The antimicrobial activity of Punica granatum L. has been widely investigated (Endo et al. 2012; Bakkiyaraj et al. 2013; Labsi et al. 2016). The crude extract of P. granatum appears to be able to inhibit microbial adhesion. Researchers have claimed that oral bacterial biofilms and C. albicans were sensitive to this extract. Considering the gaps in knowledge about the mechanism of action and the bioactive principles of these microorganisms, tannins, which are the main polyphenols of the P. granatum extract, are believed to act on cellular metabolism through the cell walls. These compounds bind to the cell wall, cross this structure and interfere with the production of proteins and enzymes responsible for microbial adhesion (Vasconcelos et al. 2006). Thus, these herbal medicines could play an important role in the treatment and/or prevention of DS (Casaroto and Lara 2010; Alavarce et al. 2015). Overall, these herbal medicines contain compounds with antimicrobial activity, and, in recent years, there has been growing interest in identifying them (Endo et al. 2010; Anibal et al. 2013).
A Proprietary Herbal Blend Containing Extracts of Punica granatum Fruit Rind and Theobroma cocoa Seeds Increases Serum Testosterone Level in Healthy Young Males: A Randomized, Double-Blind Placebo-Controlled Study
Published in Journal of Dietary Supplements, 2023
Poorna Gopal Azad Sreeramaneni, Amulya Yalamanchi, Manikyeswara Rao Konda, Sree Harsha Varma Cherukuri, Joseph C. Maroon
Punica granatum L., commonly known as the pomegranate, is one of the most popular edible fruits of tropical and subtropical regions. In traditional medicine, the juice of the fruit and its pericarp is considered beneficial for the treatment of colic, colitis, menorrhagia, headache, and other conditions (9, 10). Pomegranate fruit rind is a rich source of anti-oxidant phytochemicals that include ellagitannins, gallic acid, ellagic acid, flavonols such as quercetin, myricetin; flavones such as luteolin and anthocyanidins; cyanidin, and pelargonidin (11). The fruit rind has various pharmacological activities such as anti-oxidant, immunomodulatory, anti-diabetic, anti-plasmodial, anti-microbial, wound healing, anti-hyperglycaemic, hepatoprotective, anti-diarrhoeal, etc (9, 12).
Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation in vitro
Published in Nutritional Neuroscience, 2019
Nicholas A. DaSilva, Pragati P. Nahar, Hang Ma, Aseel Eid, Zhengxi Wei, Susan Meschwitz, Nasser H. Zawia, Angela L. Slitt, Navindra P. Seeram
The pomegranate (Punica granatum L.) fruit, which is popularly consumed as juice and botanical dietary supplements/extracts, is a rich source of ellagitannins, a class of bioactive polyphenols, which release ellagic acid on hydrolysis. Extensive human and animal studies have shown that while pomegranate ellagitannins are not bioavailable, their gut microbial-derived metabolites, known as urolithins (formed from colonic microflora biotransformation of ellagic acid), achieve detectable concentrations and persist through enterohepatic circulation in vivo.5 Consequently, urolithins are widely regarded as relevant in vivo compounds which contribute, in part, to the biological effects attributed to pomegranate consumption.5