China
Africa
Explore chapters and articles related to this topic
Imbalance
Published in R James A England, Eamon Shamil, Rajeev Mathew, Manohar Bance, Pavol Surda, Jemy Jose, Omar Hilmi, Adam J Donne, Scott-Brown's Essential Otorhinolaryngology, 2022
Symptoms can be treated with a variety of vestibular sedatives: Antihistamines for acute-on-chronic vertigoDopamine antagonists: Not to be used in children <10 kgExtrapyramidal side effects can be treated with procyclidine.HT3 antagonists: Powerful antiemeticsHighly effective in acutely vertiginous child
Schizophrenia
Published in Ben Green, Problem-based Psychiatry, 2018
Procyclidine is an example of an anticholinergic, often prescribed with antipsychotics to overcome acute movement disorders like dystonia and other cholinergic side-effects. Such anticholinergics should not be prescribed automatically with antipsychotics, but on a more rationalised basis.
Drug therapy
Published in Jeremy Playfer, John Hindle, Andrew Lees, Parkinson's Disease in the Older Patient, 2018
It is a common misconception that these drugs are effective in preventing Parkinson’s signs and tardive dyskinesias in patients on neuroleptic drugs, whereas in fact they may worsen both of these conditions.44 Procyclidine and benzatropine, when given parenterally, have been shown to be effective as an emergency treatment for acute drug-induced dystonic reactions, and this is probably now their main indication for use.45
Metabolism of the areca alkaloids – toxic and psychoactive constituents of the areca (betel) nut
Published in Drug Metabolism Reviews, 2022
A PD interaction was reported in two schizophrenic patients maintained on depot neuroleptics (fluphenazine decanoate or flupenthixol) who both heavily consumed AN (Deahl 1989). Both patients experienced severe extrapyramidal symptoms in spite of being maintained on procyclidine, an anticholinergic agent that prevents extrapyramidal side effects induced by neuroleptics (Deahl 1989). A possible mechanism proposed in this report was PD antagonism, since arecoline, a known cholinergic agonist (Horenstein et al. 2019), may counter the anti-cholinergic effects of procyclidine (Deahl 1989).
Balamuthia mandrillaris: pathogenesis, diagnosis, and treatment
Published in Expert Opinion on Orphan Drugs, 2020
Mohammad Ridwane Mungroo, Naveed Ahmed Khan, Ruqaiyyah Siddiqui
Procyclidine, an anticholinergic drug commonly used to treat akathisia, acute dystonia, and Parkinson's disease, showed amoebicidal activity against B. mandrillaris at a concentration of 250 μM [69]. The activity of the drug on the amoeba was shown to be irreversible as they did not grow when seeded on brain endothelial cells, confirming that the activity was amoebicidal [65].