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Hair Cosmetics and Cosmeceuticals
Published in Rubina Alves, Ramon Grimalt, Techniques in the Evaluation and Management of Hair Diseases, 2021
Aurora Alessandrini, Michela Starace, Bianca Maria Piraccini
Beside normal shampoos, there is the group of “medicated” shampoos, which contain active ingredients selected to treat medical conditions, mainly seborrheic dermatitis or psoriasis. Active ingredients include tar derivates, salicylic acid, ketoconazole, ciclopirox olamine, zinc pyrithione, piroctone olamine, selenium sulfide, poly-vinyl-pyrrolidone, iodine complex, menthol, and colloidal sulfur. The combination of cosmetic and medical therapy allows the benefits of cosmetic products together with the efficacy of medical agents.
Hair cosmetology
Published in Pierre Bouhanna, Eric Bouhanna, The Alopecias, 2015
Claude Bouillon, Michèle Verschoore
Efficient and safe antifungal agents are available, mainly zinc pyrithione (ZPT), piroctone olamine, selenium sulfide, climbazole, and ketoconazole, used at 0.5–1.5 g% in anti-dandruff shampoos. Regular application (i.e., twice a week) of such active ingredients within a mild cleansing base significantly eliminates the symptoms and improves scalp condition.
Novel drug delivery approaches for the management of hair loss
Published in Expert Opinion on Drug Delivery, 2020
Waleed Alsalhi, Ammar Alalola, Michael Randolph, Eran Gwillim, Antonella Tosti
Minoxidil encapsulated nanoparticles have largely been studied in animals. Minoxidil encapsulated poly(L-lactide-co-glycolide) nanoparticles (PLLGA) prepared using water-in-oil-in-water solvent evaporation (W/O/W) and sonification were percutaneously administered to mice and resulted in 2.5 times hair follicle delivery compared to standard minoxidil solution [35]. Chitosan, a natural polymeric nanoparticle, was used as a minoxidil sulfate carrier and was shown to have a sustained release time, five times that of minoxidil solution, and to provide a twofold increase of minoxidil in hair follicle when applied to porcine ear skin [36]. Additionally, nanoparticles had less irritant effect compared to commercial solution [37]. Lipid nanoparticles were developed as carries for the delivery of topical finasteride and minoxidil, they were found to maintain good stability with ability to be stored for at least 28 days [38]. Data on nanoparticle delivery in humans are still limited but a small non controlled prospective study showed that topical application of a solution containing 5% NanoxidilR (a nanosome-based preparation of Pyrrolidinyl Diaminopyrimidine Oxide, a potassium channel opener, Azelaic acid, Copper Tripeptide-1, Lysophosphatidic acid) and several hair growth promoters including myristoyl pentapeptide-17, adenosine, piroctone olamine, retinol, and caffeine, significantly reduced hair shedding, and increase the hair mass and density at 3 and 6 month in 49 women with female pattern hair loss [39].