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Antihistamines, Decongestants, and Expectorants during Pregnancy
Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022
The frequency of birth defects was not increased among 865 infants born to women who used diphenhydramine during the first trimester (Aselton et al., 1985; Heinonen et al., 1977). No studies regarding the use of bromodiphenhydramine during pregnancy are published. Ten normal infants whose mothers were exposed to bromodiphenhydramine during early gestation were reported (Heinonen et al., 1977), but this cannot be related to risk of birth defects. Ethanolamine derivatives are reported to have oxytocic-like effects when used parenterally (Hara et al., 1980; Klieger and Massart, 1965; Rotter et al., 1958).
Antibodies and Antisera
Published in Lars-Inge Larsson, Immunocytochemistry: Theory and Practice, 2020
In spite of these limitations, antigen-coated beads have served well in many investigations. They are also very frequently used in solid-phase absorptions. A description of their preparation is given in the Appendix. It should be noted that following addition of the antigen to the beads, many unoccupied reactive sites may still occur on them. These sites must be blocked in order to prevent covalent binding of subsequently applied reagents (e.g., antibodies). Such blocking of cyanogen bromide-activated Sepharose® may be carried out with either an inert protein, amino acids, or ethanolamine. The use of ethanolamine is strongly advocated for this purpose. Thus, a bulky protein may cause steric hindrance, and amino acids will introduce carboxyl groups, thereby turning the beads into an ion exchanger.
Ocular Irritation Testing
Published in David W. Hobson, Dermal and Ocular Toxicology, 2020
George P. Daston, F. E. Freeberg
There have been a few published studies which have directly compared the skin and eye irritating potentials of a representative sampling of materials. For example, Dutertre-Catella et al.62 compared these two parameters for a series of ethanolamines. They reported good correlation between the dermal and ocular irritancies of these compounds. Ciuchta and Dodd63 compared the ocular and dermal irritancy of seven surfactants and reported good agreement between the tests in how they rank ordered the seven.
Biomolecular assembly on interdigitated electrode nanosensor for selective detection of insulin-like growth factor-1
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2021
Yan Gu, Lijie Liu, Jian Guo, Shun Xiao, Fang Fang, Xiaoyun Yu, Subash C. B. Gopinath, Jianlie Wu, Xunqiang Liu
IGF1, IGF2 Anti-IGF1 were procured from Sino Biological (China). Al-coil, Phosphate buffered saline (PBS). Al-etching solution, and 1,1′-Carbonyldiimidazole (CDI) and human serum were acquired from Sigma-Aldrich (USA). Ethanolamine was received from Fisher Scientific (UK). Biotinylated-aptamer for IGF1 detection was synthesized and received from the local supplier. The original aptamer sequence (5′-ATACGGGAGCCAACACCAGATGCGAGGACGGTGGGTGGGAGGGTGGAGGTCTCGAGAGCAGGTGTGACGGAT-3′) was adopted from the earlier report [29]. For the control experiment, the non-complementary sequences of the aptamer (5′-TATGCCCTCGGTTGTGGTCTACGCTCCTGCCACCCACCCTCCCACCTCCAGAGCTCTCGTCCACACTGCCTA-3′) were prepared. Silica wafer was received from Mallinckrodt Baker (USA). Resist developer and positive photoresist were purchased from Futurrex Inc. (USA).
Hybrid nanocarrier system for guiding and augmenting simvastatin cytotoxic activity against prostate cancer
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Mohammed Sedki, Islam A. Khalil, Ibrahim M. El-Sherbiny
Appropriate amounts of FeCl3 and FeCl2 (molar ratio Fe3+:Fe2+ of 2:1) were dissolved in 25 ml de-oxygenated distilled water. In this protocol, ethanolamine was used as the base. 3% ethanolamine solution was added dropwise to the reaction mixture under nitrogen purging, and at 60 °C with stirring to increase the pH to 11. After agitation for 3 h, the products were separated from reaction mixture by an external magnet, washed with distilled water and dried at 50 °C to obtain SPIONS. The morphology and size of the prepared SPIONS were determined by high resolution transmission electron microscope HR-TEM (JEM-2100F; JEOL, USA), and zetasizer (Nano-ZS, Malvern, UK) while their magnetic properties were assessed using vibrating sample magnetometer (VSM).
Preparation and evaluation of tumour microenvironment response multistage nanoparticles for epirubicin delivery and deep tumour penetration
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Jialing Dai, Shangcong Han, Fang Ju, Mei Han, Lisa Xu, Ruoyu Zhang, Yong Sun
tBAM was synthesized according previous procedure [19]. Ethanolamine was dissolved in 100 ml, 1 M, NaOH, and stirred. Then, di-tert-butyl dicarbonate (Boc2O) was dissolved in 50 ml 1,4-diethylene dioxide added into ethanolamine solution, reaction 48 h. Termination reaction with water addition and extracted with ethyl acetate three times. The organic phase was washed with saturated salt water and dried with anhydrous magnesium sulphate. After vacuum drying, a yellow oil product, Boc-ethanolamine, was obtained. Boc-ethanolamine and triethylamine were dissolved in anhydrous CH2Cl2, pre cooling in an ice water bath for 20 min and nitrogen protection, under magnetic stirring condition by dropwise addition of methacryloyl chloride and sealing. The reaction mixture was allowed to warm to room temperature and stirred overnight. The reaction mixture was washed with water, 10% citric acid and 10% K2CO3, sat.NaHCO3 and brine. The organic layer was dried over Na2SO4, and the solvent was evaporated under reduced pressure. The product was purified by recrystallization from CH2Cl2/hexane to give the product.