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Mitigation of Obesity: A Phytotherapeutic Approach
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
A.B. Sharangi, Suddhasuchi Das
Dolichos biflorus, belonging to family Leguminosae, is a twining herb of Old-World tropics and cultivated in India for food and fodder. Piper betle belongs to the Piperaceae family, which includes pepper and kava also. It is observed that the combined extract of the above two mentioned plants is used to prepare the herbal formulation LI10903F which shows considerable adipogenesis having the capacity to reduce lipid accumulation in 3T3-L1 adipocytes and demonstrate lipolysis (Sengupta et al., 2012).
ANTIDIABETIC ACTIVITY OF Hypericum mysorense Heyne
Published in V. R. Mohan, A. Doss, P. S. Tresina, Ethnomedicinal Plants with Therapeutic Properties, 2019
V. Sornalakshmi, P. S. Tresina, K. Paulpriya, V. R. Mohan
In the present scenario, medicinal plants are used as pharmaceuticals in the treatment of several diseases. In the present study, H. mysorense leaf and bark ethanol extracts were prepared and orally administrated to the diabetic animals. A standard hypoglycemic drug, glibenclamide was used to treat the diabetic rats in order to compare the activity of the H. mysorense. In the present study, the loss in body weight observed in alloxan-induced diabetic rat group (Group I) (after a period of 21 days) may be due to muscle wasting and loss of tissue proteins upon indication of diabetes with alloxan (Kumar et al., 2011; Poongothai et al., 2011). Treatment with H. mysorense leaf and bark extracts improved body weight to a certain extent, indicating that control over muscle wasting resulted from glycemic control. This suggests the hypoglycemic effect of H. mysorense in diabetic rats. Ethanol extracts of H. mysorense leaf and bark treatment in diabetic-treated group for 21 days resulted in significant reduction (p < 0.05, p < 0.01) in their FBG levels. FBG reduction was higher in the H. mysorense bark ethanol extract and these effects were higher than those of the standard oral hypoglycemic agent, glibenclamide. Earlier, Santhakumari et al. (2006) and Kaleem et al. (2005) reported 26% and 52% reduction in the FBG levels of diabetic rats treated with aqueous extracts of Piper betle leaves and Piper nigrum seeds, respectively for 30 days.
The art and science of surgery
Published in Lois N. Magner, Oliver J. Kim, A History of Medicine, 2017
Archeological evidence indicates that opium, magic mushrooms, fermented beverages, and other psychoactive substances have been used all over the world. For example, people have been chewing betel leaves for thousands of years. The leaves of the betel plant (Piper betle) are known by many names in various Asian countries. Chemists have identified compounds in the plant that have anesthetic and psychoactive, euphoria-inducing properties. In Ayurvedic medicine, betel leaves were recommended as a cure for bad breath, but habitually chewing betel leaves stains the teeth. Human teeth with characteristic reddish betel stains were discovered in a burial pit in a cave in the Philippines. Betel stains have also been found on the teeth of human remains that date between 2400 and 2000 bce, excavated from a Bronze Age site in Vietnam.
Anticancer Potential of Hydroxychavicol Derived from Piper betle L: An in Silico and Cytotoxicity Study
Published in Nutrition and Cancer, 2022
S. Vinusri, R. Gnanam, R. Caroline, V. P. Santhanakrishnan, A. Kandavelmani
Phenolic compounds are secondary metabolites produced in higher plants and microorganisms through shikimic acid and phenylpropanoid metabolic pathways. Because of their antioxidant and anti-inflammatory properties, natural polyphenolics reduce the risk of various classes of tumors, especially chronic myeloid leukemia (1). These compounds possess an aromatic ring with one or more hydroxyl groups and have multiple roles, such as radical scavenging activity, plant defense mechanisms, and antimicrobial activity (2). Piper betle L. is a medicinal plant and a rich source of polyphenolic bioactive compounds, such ashydroxychavicol, terpinen-4-ol, safrole, allylpyrocatecholmonoacetate, eugenol, eugenyl acetate, α-cadinene, β-elemene, piper betol, carvacrol, allyl catechol, chavicol, p-cymene, caryophyllene, chavibetol, cineole, and estragole (3).
In silico molecular docking for assessing anti-fungal competency of hydroxychavicol, a phenolic compound of betel leaf (Piper betle L.) against COVID-19 associated maiming mycotic infections
Published in Drug Development and Industrial Pharmacy, 2022
Vinusri Sekar, Gnanam Ramasamy, Caroline Ravikumar
In view of the above facts, the present study was executed to explore the medicinal benefits of phytochemicals of Piperaceae family, a rich source of several medicinally significant compounds. Amidst the several crops of Piperaceae family, Piper betle L. holds its position from the ancient time onwards with huge medicinal, traditional and commercial significance [35]. Its dark shiny fresh leaves and sometimes petioles also are used to treat respiratory issues, cold, cough, skin diseases, gastric issues and indigestion problems [36]. The compounds identified in the P. betle are found to have excellent medicinal properties such as anti-bacterial, anti-fungal, anti-oxidant, stimulant, analgesic, anti-nitrosation, anti-mutagenic, anti-pyretics and anti-tumour activities. Betel leaf extract was proved to have strong antimicrobial effects [36–40]. The anti-fungal property of betel extract was firmly established [41–45].
Biofilm inhibition and anti-quorum sensing activity of phytosynthesized silver nanoparticles against the nosocomial pathogen Pseudomonas aeruginosa
Published in Biofouling, 2019
Saloni Shah, Swapnil Gaikwad, Shuchi Nagar, Shatavari Kulshrestha, Viniti Vaidya, Neelu Nawani, Sarika Pawar
Silver nanoparticles (AgNPs) are attracting much attention in the fields of biomedical technology because of their antibacterial, anti-biofilm, anti-cancer and antioxidant properties (Taglietti et al. 2014; Ghosh et al. 2015; Zhang et al. 2016). There are reports on anti QS and the biofilm inhibitory activity of green synthesized AgNPs/nanocomposites (Masurkar et al. 2012; Singh et al. 2015; Kulshrestha et al. 2017; Srinivasan et al. 2017). Piper betle L. (Pb) is a widely cultivated plant in the Indian subcontinent and Southeast Asia and has long been in use for several medicinal formulations. There are a few reports on Pb-functionalized AgNPs (Pb-AgNPs) for their antibacterial, anti-QS and anti-cancer activities (Shanmuga Prabha et al. 2014; Preethi and Padma 2016; Srinivasan et al. 2017), but the anti-QS and anti-biofilm activity of Pb-AgNPs against P. aeruginosa PAO1 have not been explored so far. Here one-step synthesis of AgNPs has been demonstrated using Pb leaf extract and the anti-QS and anti-biofilm activity of these nanoparticles against P. aeruginosa PAO1 is evaluated. Further, the mechanism of action of AgNPs and eugenol-conjugated AgNPs was examined by computational molecular docking with P. aeruginosa PAO1 quorum sensing regulator proteins.