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Functional Benefits of Ficus Hispida L.
Published in Hafiz Ansar Rasul Suleria, Megh R. Goyal, Health Benefits of Secondary Phytocompounds from Plant and Marine Sources, 2021
D. Suma, A. Vysakh, R. N. Raji, Ninan Jisha, M. S. Latha
The pharmacological activity has been investigated in a few members of the plant population till date. Only 5–10% of the plants have been explored so far among 250,000 species of plants that exist on this earth. Phytochemistry is the study of natural products (chemicals) collected from the plants. Phytochemicals or phytoconstituents are biologically dynamic, innately available chemical constituents available in plants, which can deliver health welfare to human beings. Phytoconstituents are mainly classified as primary and secondary chemicals based on chemical reactions related to plants.
Ethnobotany of the Silk Road – Georgia, the Cradle of Wine
Published in Raymond Cooper, Jeffrey John Deakin, Natural Products of Silk Road Plants, 2020
Rainer W. Bussmann, Narel Y. Paniagua Zambrana, Shalva Sikharulidze, Zaal Kikvidze, David Kikodze, David Tchelidze, Ketevan Batsatsashvili
Rhododendron caucasicum phytochemistry: Diterpenoids (andromedotoxine), phenols (campanuline, friedeline, taraxerol, uboyol, ursolic, and oleanolic acid) steroids (sitosterol), phenolcarbon acids, catechins (catechine, catechine, gallocatechine, epigallocatechine, epicatechine) flavonoids (quercetine, quercetrine), essential oils (citronellol, geraniol, nerol, a-terpineol, linalool, farnesol), anthocyanins (Sokolov, 1985).
Application of Phytodrug Delivery in Anticancer Therapy
Published in Madhu Gupta, Durgesh Nandini Chauhan, Vikas Sharma, Nagendra Singh Chauhan, Novel Drug Delivery Systems for Phytoconstituents, 2020
Although phytodrugs have shown great promise in the clinic, there is a clear caveat concerning its safety, even though phytodrugs are usually considered as mild medicines. It should be noted that phytodrugs present both desired and undesired effects during cancer therapy. Therefore, extensive clinical studies and scientific analyses such as phytochemistry, pharmacognosy, or molecular biological approaches remain to be applied to clarify the underlying mechanisms of action as well as toxicity of phytodrugs, to promote more extensive application of phytodrugs in cancer therapy.
Biosynthesis, characterization of magnetic iron oxide nanoparticles and evaluations of the cytotoxicity and DNA damage of human breast carcinoma cell lines
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Ghassan M. Sulaiman, Amer T. Tawfeeq, Amal S. Naji
Historically, members of the Fabaceae family, particularly Albizia adianthifolia are easily available and grow abundantly in the east coast of South Africa. A. adianthifolia is used in Central and West Africa for the treatment of skin diseases, inflamed eyes, bronchitis, tapeworm, headaches and sinusitis [20]. It is reported that root and bark extracts from A. adianthifolia inhibit acetylcholinestarase and cyclooxygenase activity. These anti-inflammatory properties may be useful in the treatment of human diseases related to oxidative stress [21]. The phytochemistry of this plant has not been elucidated adequately. However, saponins such as prosapogenins and triterpenesaponins were identified; they display a broad range of pharmacological and biological properties [22,23].
Profiling and identification of chlorogenic acid metabolites in rats by ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometer
Published in Xenobiotica, 2018
Fei Wang, Zhanpeng Shang, Lulu Xu, Zhibin Wang, Wenjing Zhao, XiaoDan Mei, Jianqiu Lu, Jia Yu Zhang
Phytochemistry studies demonstrated that phenolic acids, iridoid glycosides, saponins and flavonoids are the major constituents of Flos Lonicera Japonica. Among them, chlorogenic acids (CGAs) are a large family of phenolic acid esters composed of quinic acid and 1–4 residues of certain cinnamic acids, most commonly caffeic, p-coumaric and ferulic acids (Clifford, 2000; Clifford et al., 2006a, 2010; Jaiswal et al., 2011a; Jaiswal & Kuhnert, 2011b, 2011c). In addition, CGAs also exist in other species, such as coffee beans (Clifford et al., 2008), Gallium odoratum lettuce (Jaiswal et al., 2014), Rudbeckia hirta (Jaiswal et al., 2011a), Ilex paraguariensis (Jaiswal et al., 2010), Stevia rebaudiana (Karakose et al., 2011), etc. According to relevant pharmacological researches, CGAs possesses many biological activities, such as anti-bacterial (Karunanidhi et al., 2013), anti-oxidant (Stalmach et al., 2006), anti-inflammatory (Chan et al., 2008), anti-nociceptive (Yoo et al., 2008), anti-angiogenic (Yoo et al., 2008) and anti-viral (Gamaleldi et al., 2016) activities. In our previous report, caffeoylquinic acids (CQA), dicaffeoylquinic acids (DiCQA), p-coumaroylquinic acids (p-CoQA) and feruloylquinic acids (FQA) are the main classes of CGAs found in Flos Lonicera Japonica (Zhang et al., 2016). However, the information regarding absorption, distribution, metabolism, excretion and toxicity (ADME/T) of CGAs in Flos Lonicera Japonica remains unclear. Therefore, it is important to extensively study their ADME/T process, particularly the characterization of metabolites, which can help in explaining and predicting various events related to the efficacy and toxicity of CGAs (Holcapek et al., 2008; Levsen et al., 2005).
Polydatin-Induced Direct and Bystander Effects in A549 Lung Cancer Cell Line
Published in Nutrition and Cancer, 2022
Lung cancer is the second most common cancer to be diagnosed in both men and women worldwide and contributes to the maximum number of cancer-related deaths (1). With the development in phytochemistry, the use of phytochemicals as chemotherapeutics and chemopreventives is evolving as a promising approach for the management of this cancer type (2). Therefore, in the present study, we have used polydatin, a natural precursor of resveratrol, to check its anticancer effect and mechanism of action on A549 lung cancer cell line.