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Experimental Stomatology
Published in Samuel Dreizen, Barnet M. Levy, Handbook of Experimental Stomatology, 2020
Samuel Dreizen, Barnet M. Levy
Mesrobian and Shklar38 looked into the effect of dietary zinc sulfate on the healing of experimental extraction wounds. In this study, 62 Syrian hamsters were subjected to a lower first molar extraction under i.p. anesthesia. Of the group, 31 hamsters received a supplement of zinc sulfate in the drinking water amounting to an average daily intake of 1.3 mg of the salt, whereas 31 were given unsupplemented water. All consumed the same laboratory chow. Sacrifice times ranged from 3 days to 14 weeks after extraction. At necropsy, the jaws, were removed, fixed in 10% formalin, and processed for histologic examination of hematoxylin and eosin stained sections.
Social Psychology
Published in Mohamed Ahmed Abd El-Hay, Understanding Psychology for Medicine and Nursing, 2019
Aggression refers to any behavior whose intent is to harm another person (Bushman & Huesmann, 2010). Aggression is expressed in a countless number of behaviors that involve the intention to harm another, whether physical or verbal in nature. Thus, although significant pain and distress may be caused by extracting a tooth, this is not aggressive behavior, as there is no intent to harm.
An enigmatic approach in Ayurvedic Pharmacopoeia of India
Published in C. P. Khare, Evidence-based Ayurveda, 2019
Extracts: The modernization of the Ayurvedic drug industry is experimenting with various extraction techniques. More and more capsules and tablets appearing in the market are based on products using extraction techniques. Even liquids like syrups, medicated oils, and other oral suspensions depend on the extracts. Extraction is essential to reduce the bulk of the drug material and enhance its potency, acceptability, and convenience of administration of the drug. The purpose of standardized extraction procedures for crude drugs is to acquire the therapeutically desired portion and eliminate inert material, by treatment with a selective solvent known as the menstruum. The extract thus obtained is used as a medicinal agent directly, or further processed to be incorporated in any dosage form such as a tablet, capsule or syrup.
Risk of bleeding with dental implant surgery in patients on anticoagulant or antiplatelet drugs: a systematic review and meta-analysis
Published in Acta Odontologica Scandinavica, 2023
Much research has been conducted on the bleeding risk with dental surgery in patients under OAC or AP therapy. However, most of it has been focussed on dental extraction as it is the most common minor oral surgical procedure [7,8]. Shi et al. [7] in a recent meta-analysis of 12 studies have indicated that the risk of bleeding is greater in anticoagulated patients undergoing minor oral surgery as compared to healthy controls. The majority of studies in their review were on dental extraction with just four studies focussing on dental implants. In another study, Bajkin et al. [9] have reviewed the literature on bleeding tendencies after implant placement in anticoagulated patients but no meta-analysis was conducted in their review. Despite the widespread use of OAC and AP drugs as well as dental implantation procedures in the general population, it is still not clear how these medications influence the risk of bleeding following surgical placement of a dental implant. There is a need for evidence on the risk of bleeding with AP, OAC, different types of OAC (Vitamin K antagonists [VKAs] and direct oral anticoagulants [DOACs]), and between AP vs. OAC to guide clinical practice. Thus, this study aimed to conduct a systematic literature search and pool evidence on the risk of bleeding in patients under AP and OAC therapy undergoing dental implant surgery.
Pain, discomfort, and functional impairment after extraction of primary teeth in children with palatally displaced canines – a randomized control trial comparing extraction of the primary canine versus extraction of the primary canine and the primary first molar
Published in Acta Odontologica Scandinavica, 2023
Sigurd Hadler-Olsen, Jeanett Steinnes, Hege Nermo, Anders Sjögren, Elin Hadler-Olsen
Extraction procedures generally induced more discomfort than pain, both being highest during injection of anaesthesia. The discomfort decreased gradually from the injection of anaesthesia until one-week post-extraction, whereas pain was lower during extraction than on the evening of the extraction day. The mean level of pain and discomfort reported by the children never exceeded mild (VAS <45 mm) for any of the procedures or time points (Table 2). However, at the individual level, one child reported severe pain (in the DEG) and two children had moderate pain (in the SEG) during injection of anaesthesia. Two children reported moderate pain during extraction (both in the DEG) and two reported moderate or severe pain in the evening of the extraction day (both in the DEG). Compared to children in the SEG, children in the DEG reported significantly higher levels of pain and discomfort during injection and extraction as well as on the evening of the extraction day (Table 2).
Tucumã (Astrocaryum aculeatum) extract: phytochemical characterization, acute and subacute oral toxicity studies in Wistar rats
Published in Drug and Chemical Toxicology, 2022
Camille Gaube Guex, Gabriela Buzatti Cassanego, Rafaela Castro Dornelles, Rosana Casoti, Ana Martiele Engelmann, Sabrina Somacal, Roberto Marinho Maciel, Thiago Duarte, Warley de Souza Borges, Cínthia Melazzo de Andrade, Tatiana Emanuelli, Cristiane Cademartori Danesi, Euler Esteves Ribeiro, Liliane de Freitas Bauermann
This study is registered in the Sistema Nacional de Gestão de Patrimônio Genético e do Conhecimento Tradicional Associado (SisGen) under the number A75395F. Tucumã fruit was collected directly from native palm trees found in primary and secondary forests, pastures and home gardens, being obtained from a composite sample representing a mixture of progenies from Manaus City (Amazonas State, Brazil), located in the Amazonian region (3°6′26″S, 60°1′34 ″W). Tucumã usually blooms from June to January and produces fruit from February to August; we obtained the fruits (5 kg) from Manaus city in August, 2017. According to Sagrillo et al. (2015), the tucumã ethanolic extract was prepared from tucumã pulp that was crushed and placed separately into sealed amber glass jars containing an absolute ethanol solution at a ratio of 1:5 (w/v) for extraction. The extraction was performed over four days at room temperature with daily agitation. The homogenate was filtered through Whatman No. 1 paper and then collected; the ethanol was removed using a rotary evaporator at reduced pressure, 25 °C at 115 rpm. Following this procedure, the pulp extract was lyophilized and stored at –20 °C until the use. We obtained 109 g of dried tucumã pulp extract.