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Aesthetic
Published in Tor Wo Chiu, Stone’s Plastic Surgery Facts, 2018
Minocycline-induced pigmentation is a rare side effect that can take years to resolve. The mainstay treatment has been QS alexandrite laser, usually requiring several treatments. The authors found that 1-2 treatments with the 755 nm picosecond laser was sufficient.
Information on level of drugs into breastmilk
Published in Wendy Jones, Breastfeeding and Medication, 2018
Minocycline should also be taken with a full glass of water while remaining upright in order to avoid oesophageal ulceration. A black chaelate of minocycline has been found in the breastmilk of two women causing the production of black milk; this may also be involved in skin pigmentation that is associated with minocycline (Basler and Lynch 1985; Hunt et al. 1996). In a study of two patients given a single dose of minocycline 200 mg, peak milk levels of 0.8 mg per litre were measured at six hours after the dose (Mizuno et al. 1969). The most frequent use of minocycline is to treat acne vulgaris. Although milk levels may be low, the risk of dental staining cannot be quantified so the drug should be avoided other than in short courses. Relative infant dose is quoted as 0.2–1.4% (Hale 2017 online access). The BNF recommends that tetracyclines should not be given to women who are breastfeeding (although absorption and therefore discolouration of teeth in the infant is probably usually prevented by chelation with calcium in milk).
The Management of Treatment-Resistant Depression
Published in Dr. Ather Muneer, Mood Disorders, 2018
Tetracycline antibiotics, doxycycline and minocycline, also have potent anti-inflammatory effects and are currently being evaluated for the treatment of MDD. Preclinical data for minocycline indicate that it exerts antidepressant effects through its anti-inflammatory, antioxidant, anti-glutamatergic and neuroprotective properties.27 Clinical trials are currently underway to investigate minocycline as an adjunctive therapy for MDD and bipolar depression. Doxycycline has also demonstrated promise, as recent preclinical data show improvement of depressive-like behavioral manifestations in inflammatory mouse models.28 Currently no clinical trials for tetracycline antibiotics for TRD have been reported; however, because of their preclinical effects, these pleiotropic agents are of interest in TRD.
Therapeutic options for difficult-to-treat Acinetobacter baumannii infections: a 2020 perspective
Published in Expert Opinion on Pharmacotherapy, 2021
Matteo Bassetti, Laura Labate, Chiara Russo, Antonio Vena, Daniele Roberto Giacobbe
A tetracycline (minocycline) and a glycylcycline (tigecycline) are also considered among the options for treating severe DTR-AB infections [52,53]. Generally speaking, minocycline is an attractive option, owing to good tolerability, low cost, and availability of an oral formulation. In a recent meta-analysis of 10 observational studies (of which 9 retrospective), the lung was the most frequent site of infection, and mortality in patients treated either with minocycline monotherapy or with minocycline-including combined regimens was 21% (35/167) [52]. However, it should be noted that this result was the sum of deaths in the different studies, and it was thus unadjusted for between-study differences. Furthermore, the retrospective, observational nature of most included studies inherently implies a serious/critical risk of bias. Consequently, the use of minocycline for severe DTR-AB infections would still require support by dedicated RCT data before being universally recommended. Tigecycline is an important option for complicated intraabdominal infections (cIAI) due to tigecycline-susceptible DTR-AB, but its role for other more frequent types of DTR-AB infections such as VAP remains debated, due to the possible increased mortality reported in VAP patients treated with tigecycline, and based on pooled data from RCT [6]. Nonetheless, sometimes in clinical practice tigecycline may remain the only active agent for DTR-AB VAP, and its use at higher dosage than usual may thus be considered by clinicians in the absence of dependable alternatives [54–56].
Successful treatment of infectious delayed union after ulnar shortening osteotomy using once-weekly teriparatide with low-intensity pulsed ultrasound
Published in Case Reports in Plastic Surgery and Hand Surgery, 2021
Kiyohito Takamatsu, Takuya Uemura, Ema Onode, Masaru Koshimune
Five months after the operation, the patient complained of swelling and pain at the surgical site and loosening of the screw and radiolucency at the osteotomy site were observed on X-ray (Figure 1(C,D)). White blood cell count and C-reactive protein (CRP) levels were 9100/µL and 0.02 mg/dL, respectively. In view of the loosened hardware, we removed the plate. However, intraoperatively, abscess formation at the osteotomy site and around the loosened screw was found and no bony union was noted. We diagnosed infected delayed union and proceeded with removal of all screws and plate, followed by thorough debridement of the infected tissue (Figure 2(A)). The pus and infected tissue were cultured, but no growth was observed. After debridement, a short arm splint was applied for 4 weeks and then a wrist brace (Wrist care pro, Alcare Co Ltd, Tokyo Japan) was applied for additional 6 weeks, except during range of motion exercises, because there was some stability even after implant removal. The patient was administered oral linezolid 1200 mg/day for 3 weeks, but an allergic skin rash appeared. Therefore, oral minocycline 100 mg/day was administered for an additional 2 weeks. The allergic reaction to linezolid resolved a week after the drug withdrawal. The laboratory parameters were normalized 16 days after implant removal and debridement (white blood cell count, 7600/μl; CRP, 0.09 mg/dL).
Effects of combined treatment of minocycline and methylprednisolone on the expression of tumor necrosis factor alpha and interleukine-6 in experimental spinal cord injury: a light and electron microscopic study
Published in Ultrastructural Pathology, 2020
Leman Sencar, Derviş Mansuri Yilmaz, Abdullah Tuli, Sait Polat
Recent studies have reported that minocycline, a tetracycline-derived antibiotic, can induce neuroprotection through reducing apoptosis of oligodendrocytes and inflammation.4,26 Minocycline exhibits these neuroprotective effects when given intraperitoneally or intravenously after spinal cord injury.27 Minocycline has been shown to inhibit microglia and macrophage activations at the lesion site, show its neuroprotective effects and reduce neuropathic pain after injury.28 Some researchers indicated that minocycline exhibits its neuroprotective effects in other nervous system diseases such as ischemia, Huntington’s disease and amyotrophic lateral sclerosis.26 Therefore, the mechanism of action of minocycline needs to be investigated by further studies.29