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Clinical Endocrinology of Pregnant Mares
Published in Juan Carlos Gardón, Katy Satué, Biotechnologies Applied to Animal Reproduction, 2020
In addition, the administration of the PG synthetase inhibitor (meclofenamic acid) to pregnant mares after abdominal surgery diminishes the normal postsurgical rise in PGFM and facilitates fetal survival compared with that in untreated mares (Silver et al., 1979). In addition, Esteller-Vico et al. (2017) showed that estrogen suppression resulted in a decrease in circulating PGFM, which suggests that estrogens partially regulate PG production during pregnancy, since PGFM concentrations were lower but still increased during the last trimester of equine gestation in letrozole-treated mares.
Role of muscarinic receptors in cardiovascular regulation in SHR
Published in H. Saito, Y. Yamori, M. Minami, S.H. Parvez, New Advances in SHR Research –, 2020
These findings were corroborated by experiments of Hendriks et al. (1993). These authors demonstrated, that endothelium-dependent contractions evoked by muscarinic agonists were completely inhibited by meclofenamic acid and that the endothelium-dependent relaxation to acetylcholine was identical in SHR and WKY under treatment with meclofenamic acid.
Classifications
Published in Fazal-I-Akbar Danish, Ahmed Ehsan Rabbani, Pharmacology in 7 Days for Medical Students, 2018
Fazal-I-Akbar Danish, Ahmed Ehsan Rabbani
Drugs with analgesic and moderate anti-inflammatory effectsPropionic acid derivativesIbuprofenKetoprofenFenoprofenFlurbiprofenCarprofenIndoprofenNaproxenOxaprozinFenamic acid derivativesMefenamic acidMeclofenamic acidFlufenamic acidTolfenamic acid
A cysteine trapping assay for risk assessment of reactive acyl CoA metabolites
Published in Xenobiotica, 2022
Nobuyuki Kakutani, Satoru Kobayashi, Toshio Taniguchi, Yukihiro Nomura
Pooled human liver microsomes (n = 50, mixed gender) were purchased from Sekisui XenoTech, LLC (Kansas City, KS, USA). Trizma® hydrochloride solution (pH 7.4, 1 M), magnesium solution (1 M), KCl, CoA, ATP, Triton X-100, ibufenac, tolmetin, repaglinide, furosemide, zomepirac, mefenamic acid, and diclofenac were purchased from Sigma-Aldrich (St Louis, MO, USA). Acetonitrile (MeCN), glutathione (GSH), lysine, ibuprofen, fenclozic acid, indomethacin, and naproxen were purchased from Fujifilm Wako Pure Chemical Corporation (Osaka, Japan). Dithiothreitol (DTT), meclofenamic acid, probenecid, gemfibrozil, and febuxostat were purchased from Tokyo Chemical Industry (Tokyo, Japan). Benoxaprofen was purchased from Toronto Research Chemicals (Toronto, Ontario, Canada). TAK-875 was synthesised by Japan Tobacco, Inc. [35S]cysteine (Cys) and Ultima Flo M were purchased from PerkinElmer Life and Analytical Science (Boston, MA, USA). Formic acid (FA) and dimethyl sulfoxide (DMSO) were purchased from Nacalai Tesque (Kyoto, Japan). An Acquity C18 BEH column and XBridge BEH C18 column were purchased from Waters Corporation (Milford, MA, USA). The stock solutions of test compounds were prepared in DMSO or 50% water/MeCN at a concentration of 100 mM before each assay.
The influence of physicochemical properties on the reactivity and stability of acyl glucuronides†
Published in Xenobiotica, 2018
Patrick Camilleri, Akshay Buch, Brandi Soldo, Andrew J. Hutt
A similar ortho- substitution effect that again results in relative stability is observed for the glucuronides of drugs such as meclofenamic acid (45) (t½, 28.1 h) and mefenamic acid (46) (t½, 17.0) (Sawamura et al., 2010).