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Abies Spectabilis (D. Don) G. Don (Syn. A. Webbiana Lindl.) Family: Coniferae
Published in L.D. Kapoor, Handbook of Ayurvedic Medicinal Plants, 2017
The ether extract of the petals and stamen showed the presence of quercetin and luteolin and that of receptacle only, quercetin. The aqueous extract of petals and stamens yielded isoquer cetrin and glucoluteolin; and that of receptacle of the flower yielded isoquercitrin. The leaves contained quercetin, isoquercitrin, leukocyanidin, and leukodelphinidin.637 The seeds of N. nucifera contained 2.11% oil which is comprised of myristic, palmatic, oleic, linoleic, and linolenic acid.638
Nelumbo nucifera
Published in Dilip Ghosh, Pulok K. Mukherjee, Natural Medicines, 2019
Pulok K. Mukherjee, Debayan Goswami, Bhaskar Das, Subhadip Banerjee
The leaves also contain flavonoinds like isoquercitrin (34) and leucocyanidin (35) (Nakaoki 1962; Ohkoshi et al. 2007).
Identification of active compounds of traditional chinese medicine derived from maxing shigan decoction for COVID-19 treatment: a meta-analysis and in silico study
Published in Expert Review of Anti-infective Therapy, 2023
Xiaodan Guo, Yihua Lin, Fengming He, Ying Jin, Simian Chen, Ting Li, Caisheng Wu, Lin Zhang, Xueqin Chen
The study identified the top 8 molecules, namely MOL007214 (Leucocyanidin), MOL010489 (Resivit), MOL000098 (quercetin), MOL004903 (liquiritin), MOL004576 (taxifolin), MOL000006 (luteolin), MOL000492 (catechin), and MOL010788 (leucopelargonidin), which appeared most frequently in both the SP and XP docking methods. These 8 compounds were selected for further molecular docking studies. Additionally, the top 15 proteins with the highest frequency of occurrence of these 8 compounds in the same protein under the two docking protocols were identified for subsequent studies. Notably, Chen et al. illustrated the pharmacokinetic parameters (PK) of luteolin and found that after oral administration of 30 mg/kg to rats, Tmax (Time to reach maximum concentration) was 0.47 ± 0.14 h, Cmax (Maximum concentration) was 894.9 ± 222.3 ng/mL, and AUC (Area under the concentration-time curve) was 2904 ± 681 ng·h/mL [81]. Huang et al. reported the PK of quercetin and found that after oral administration of 290 mg/kg to rats, Tmax was 0.22 ± 0.09 h, Cmax was 5.07 ± 1.56 μg/mL, and AUC was 2.76 ± 1.33 μg·h/mL [82]. These data indicate that the selected compounds exhibit good PK properties.
Antioxidant and vasorelaxant effects of aqueous extract of large cardamom in L-NAME induced hypertensive rats
Published in Clinical and Experimental Hypertension, 2020
S K Kanthlal, Jipnomon Joseph, Bindhu Paul, Vijayakumar M, Uma Devi P
Spices are a source of various phytochemicals that have antioxidant, anti-inflammatory and vasodilatory effects. Hence, these agents may provide a cost effective means of managing different diseases including hypertension (11–13). Large cardamom (Amomum subulatum Roxb of family Zingiberaceae) a well-known flavoring spice native to India and Southeast Asia has been used to treat various ailments in different medicinal systems world over. The seeds of large cardamom are a good source of tonic molecules for heart, stomach, liver and kidney (14). The seeds contain cardamonin, alpinetin and glycosides such as cyanidin-3-glucoside, petunidin 3,5-diglucoside, leucocyanidin-3-О-β-d-glucopyranoside, subulin, protocatechuic acid, etc (15). The ethnomedical exploration proved that one teaspoonful of cardamom powder (including seeds and pericarp), if taken twice a day, will benefit the patients with cardiac disorders (16). Moreover, cardamonin and alpinetin are able to induce endothelium-dependent and -independent relaxation of arteries through multiple mechanisms which may contribute to their beneficial effects in the treatment of vascular disorders (17). Cyanidin-3-glucoside protects vascular endothelial cell inflammation induced by angiotensin-II by enhancing the production of superoxide dismutase (18). However, there are no scientific reports available on the effects of large cardamom in N-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats.
In vitro cytotoxicity of polyphenols from Datura innoxia aqueous leaf-extract on human leukemia K562 cells: DNA and nuclear proteins as targets
Published in Drug and Chemical Toxicology, 2020
Elham Chamani, Roshanak Ebrahimi, Khatereh Khorsandi, Azadeh Meshkini, Asghar Zarban, Gholamreza Sharifzadeh
Free radicals have a single unpaired electron which could destroy proteins, lipids, intracellular components and cause disease, especially cancer (Lobo et al. 2010). Plants are rich in bioactive compounds such as flavonoids, tannin, and alkaloids, which have antioxidant and anti-cancer properties (Afolayan and Wintola 2011). Phytochemical analysis was performed to determine the TPC, TFC and TTC of D. innoxia aqueous leaf-extract using Folin–Ciocalteu assay and aluminum chloride reagent. The TFC and TPC of 1 g of D. innoxia extract are displayed in Figure 1(D). The results indicate that the TFC and TPC of the extracts were 25 mg rutin/g extract and 13.56 ± 0.2 mg GAE/g, respectively. The TTC was 11.92 mg leucocyanidin/g extract as shown in Figure 1(D).