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Hospitality Meets Healthcare In Oncology At Cancer Treatment Centers Of America®
Published in Frederick J. DeMicco, Ali A. Poorani, Medical Travel Brand Management, 2023
Peter C. Yesawich, Ananth Mohan, Carolyn Lammersfeld, Kelly Murray
Nutrition counseling and physical activity may also help with fatigue, physical functioning, and improved quality of life. Much research still needs to be done on the clinical benefit of natural products. However, open communication in an integrative setting regarding their use, along with guidance by qualified providers, may help patients identify those which should be considered and, more importantly, those that are contraindicated for symptom management during cancer treatment. The integrative approach to care may also be beneficial in steering patients away from “alternative” treatments and delays in seeking conventional cancer care.
Introduction
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Talita Turvey, Samantha R. Loggenberg, Namrita Lall
Due to rapid development in industrialized countries, there are at least 119 chemical substances derived from 90 plant species that can be considered as important drugs commonly used in one or more countries, of which 74% were discovered due to the research and isolation of plants that are used in traditional medicine (Arvigo et al., 1993). It was reported, after a study was conducted on US-based prescription drug data, that natural products play an important role in drug treatment, with over 50% of the most prescribed drugs in the United States containing either a natural product or plant-derived compound that functioned as the active ingredient (Grifo et al., 1997). The use of alternative medicine has increased in developed countries in modern times, due to an increase in reported cases of chronic diseases. Despite the accessibility of modern treatments, the use of CAM was deemed a comforting choice of treatment by patients dissatisfied with synthetic-based drugs (Thorne et al., 2002). Medicinal plants play an important role in modern drug development, with nearly 25% of modern drugs being derived from plants that are used in traditional medicine, according to WHO (Khan and Ahmad, 2019).
Exploring Important Herbs, Shrubs, and Trees for Their Traditional Knowledge, Chemical Derivatives, and Potential Benefits
Published in Azamal Husen, Herbs, Shrubs, and Trees of Potential Medicinal Benefits, 2022
Tilahun Belayneh Asfaw, Tarekegn Berhanu Esho, Archana Bachheti, Rakesh Kumar Bachheti, D.P. Pandey, Azamal Husen
Many people in most parts of the world depend on traditional medicine for their primary health care needs. Traditional medicinal systems are used to prepare crude drugs that have a synergetic effect of treating several diseases like liver problems, cancer, malaria, stomach and skin problems, pimples, ulcerations, etc. There are considerable economic benefits in developing countries, including both indigenous and exogenous medicines and medicinal plants for the treatment of various diseases. This is because medicinal plants are the sources of natural products/ bioactive compounds, which are responsible for treating such conditions. Natural products have been used as beneficial therapeutic agents for treating many diseases for a long time. For drug discovery, bioactive compounds play an essential role in developing the newly formulated drugs that arose from a limited number of basic chemical frameworks.
Hepatoprotective effect of protocatechuic acid against type 2 diabetes-induced liver injury
Published in Pharmaceutical Biology, 2023
Kaixia Xu, Guang Lu, Qianjin Feng, Shuangchao Chen, Yonghui Wang
Current management of diabetes is based on synthetic compounds that are commonly associated with severe adverse effects. Compared to synthetic compounds, natural products are relatively non-toxic, inexpensive and available in an ingestible form (Younus and Anwar 2016). Natural products, like polyphenolic compounds derived from plants, modulate blood glucose metabolism through the amplification of cell IR and activation of insulin-like growth factor binding protein signaling pathway (Anwar et al. 2021). PCA is a natural phenolic compound widely existing in medicinal materials, vegetables and fruits, and our research discovered that PCA ameliorated the IR, oxidative stress, lipid accumulation and inflammatory cell infiltration in liver tissues of IR/D rats, and the role of PCA in IR/D rats might be mediated by regulating the NF-κB and Wnt1/β-catenin pathways, signifying PCA as a novel drug candidate for IR/D-induced liver injury.
Effect of quercetin on the pharmacokinetics of selexipag and its active metabolite in beagles
Published in Pharmaceutical Biology, 2022
Shun-bin Luo, Er-min Gu, Yu-ao Chen, Shi-chen Zhou, Chen Fan, Ren-ai Xu
It is widely believed that the phytochemicals derived from natural products are usually safe. However, people hardly realise that it may lead to serious clinically significant interactions when combined with prescription or over-the-counter drugs. Quercetin used for more than 160 years is a naturally polar auxin transport inhibitor (Fischer et al. 1997). Some researchers have reported that although cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1), cytochrome P450 family 2 subfamily A polypeptide 6 (CYP2A6), and cytochrome P450 family 2 subfamily E polypeptide 1 (CYP2E1) are not affected by the quercetin, quercetin has the potential to inhibit CYP2C8 and CYP3A4 (Chandrasekaran et al. 1978; Elbarbry et al. 2019). The in vitro study has demonstrated that selexipag is hydrolysed by CYP3A4 and CYP2C8 enzymes to the main active metabolite, ACT-333679 (Gnerre et al. 2018). However, ACT-333679 is not only metabolised by CYP3A4 and CYP2C8 but also metabolised by other ways such as the uridine 5″-diphosphoglucuronosyltransferase (UGT) enzymes, etc. (Gnerre et al. 2018).
Dihydrofolate reductase inhibitors: patent landscape and phases of clinical development (2001–2021)
Published in Expert Opinion on Therapeutic Patents, 2022
Kavita Bhagat, Nitish Kumar, Harmandeep Kaur Gulati, Aanchal Sharma, Amandeep Kaur, Jatinder Vir Singh, Harbinder Singh, Preet Mohinder Singh Bedi
From the ancient time, natural products have played a keen role in the field of drug discovery due to the diverse array of pharmacological properties. They are often used as a therapeutic agent, especially in infectious diseases and cancer diseases. Natural products are most commonly used due to their higher selectivity, lesser toxicity, and side effects as compared to the synthetic compounds [31]. It was also well known that in the drug discovery field, organic synthesis is one of the major difficult tasks to achieve. Although, there are unpredictable advancements have been made in the field of research for the exploration of novel DHFR inhibitors, but we still considered that the discovery has failed to reach the expectation due to some limitations and need to improve our work.