Oral gel loaded with penciclovir–lavender oil nanoemulsion to enhance bioavailability and alleviate pain associated with herpes labialis
Published in Drug Delivery, 2021
Khaled M. Hosny, Amal M. Sindi, Hala M. Alkhalidi, Mallesh Kurakula, Nabil K. Alruwaili, Nabil A. Alhakamy, Walaa A. Abualsunun, Rana B. Bakhaidar, Rahaf H. Bahmdan, Waleed Y. Rizg, Sarah A. Ali, Wesam H. Abdulaal, Majed S. Nassar, Mohammed S. Alsuabeyl, Adel F. Alghaith, Sultan Alshehri
Noteworthy, the chemical constituents of lavender vary depending on its variety (Białoń et al., 2019) and primarily include linalool, linalyl acetate, lavandulol acetate, and β-caryophyllene oxide (Dong et al., 2020). Compounds, such as α-terpineol, 4-terpinenol, and linalool, have shown specific antiviral activity (Król et al., 2013), while the local anesthetic activity of linalool and linalyl acetate from LO has been established (Koulivand et al., 2013). Additionally, 4-terpinenol, thymol, and carvacrol are known to exert anti-inflammatory actions, providing additional benefits against herpes labialis (Król et al., 2013).