Isothipendyl

Isothipendyl

Monographs of Topical Drugs that Have Caused Contact Allergy/Allergic Contact Dermatitis

Published in Anton C. de Groot, Monographs in Contact Allergy, 2021

Isothipendyl is an azaphenothiazine H1 receptor antagonist with antihistaminic and anticholinergic properties. It is indicated for the topical treatment of itching associated with allergic reactions. In pharmaceutical products, isothipendyl is employed as isothipendyl hydrochloride (CAS number 1225-60-1, EC number 214-957-9, molecular formula C16H20ClN3S) (1).

10H-1,9-diazaphenothiazine and its 10-derivatives: synthesis, characterisation and biological evaluation as potential anticancer agents

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Journal Information

Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2019

Beata Morak-Młodawska, Krystian Pluta, Małgorzata Latocha, Małgorzata Jeleń, Dariusz Kuśmierz, Kinga Suwińska, Aleksander Shkurenko, Zenon Czuba, Magdalena Jurzak

The modifications of the phenothiazine structure with one or two pyridine rings lead to pyridobenzothiazines and dipyridothiazines, respectively. Of the four isomeric pyridobenzothiazines (being 1-aza-, 2-aza-, 3-aza- and 4-azaphenothiazines), the 10-dialkylaminoalkyl derivatives of the 1-aza series (known as prothipendyl, isothipendyl, oxypendyl, cloxypendyl and pipazethate) are still used in the various therapies such as antipsychotic24–26, antihistaminic27,28, and antitussive29 and antiemetic drugs30.

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Monographs of Topical Drugs that Have Caused Contact Allergy/Allergic Contact Dermatitis

10H-1,9-diazaphenothiazine and its 10-derivatives: synthesis, characterisation and biological evaluation as potential anticancer agents