China
Africa
Explore chapters and articles related to this topic
Noninvasive Sensing of Serum sRAGE and Glycated Hemoglobin by Skin UV-Induced Fluorescence
Published in Andrey V. Dunaev, Valery V. Tuchin, Biomedical Photonics for Diabetes Research, 2023
Vladimir V. Salmin, Tatyana E. Taranushenko, Natalya G. Kiseleva, Alla B. Salmina
The most susceptible to glycation are “long-lived” proteins such as skin collagen or crystalline in lens. The end products of non-enzymatic stable glycation and glycooxidation are pentosidine and carboxymethyl lysine. Being accumulated in the collagen of the skin, these compounds change their structure, disrupt the morphology of the dermis, and lead to the development of diabetic dermopathy. It was found that changes in skin collagen correlate with the content of glycated hemoglobin (HbA1c) in the blood, and the degree of hyperglycemia-induced alterations in microvessel endothelial cells, and can be considered in patients with diabetes as a predictor of microangiopathies and the risk of developing specific complications, or as a marker for early diagnostics even at the preclinical stage. It is important that glycated proteins are stable compounds and characterize glycation processes over several months and/or years. Therefore, the assessment of these molecules is informative for the early diagnosis of carbohydrate metabolism disorders before the onset of clinical symptoms of the disease, as well as for identifying the risk of developing microvascular complications in patients with diabetes.
Cardiovascular Risk Factors
Published in Nicole M. Farmer, Andres Victor Ardisson Korat, Cooking for Health and Disease Prevention, 2022
In a similar study, however, involving the herbs thyme and parsley, the phenolic content and antioxidant potential of these ingredients were not related to the inhibition of advanced glycation products (Ramkissoon et al., 2012). This result suggests that for some herbs, substances other than phenolic compounds may be involved in inhibiting AGEs. Of note, these studies did not utilize cooking methods in the experiments to mimic home cooking conditions.
Dementia
Published in Michelle Tollefson, Nancy Eriksen, Neha Pathak, Improving Women's Health Across the Lifespan, 2021
Kelly J. Freeman, D. Nicole Paddock, Cristina H. Davis
Avoidance of foods high in advanced glycation end-products (AGEs) may be one of the most important recommendations for the prevention of dementia. Foods high in AGEs such as bacon, butter, fried eggs, and cheeses are generally more inflammatory, while those lower in AGEs such as vegetables, fruits, and whole grains tend to be higher in beneficial antioxidants.11 Although the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet has received a great deal of attention in recent years, we highlight avoidance of AGES as a more optimal approach. Adopting a diet that is primarily whole-food plant-based, and sustained over a long period of time, has the greatest potential for optimal brain health and prevention of dementia.
Evening primrose oil attenuates oxidative stress, inflammation, fibrosis, apoptosis, and ultrastructural alterations induced by metanil yellow in the liver of rat: a histological, immunohistochemical, and biochemical study
Published in Ultrastructural Pathology, 2023
Amany Mohamed Shalaby, Rania H. Shalaby, Mohamed Ali Alabiad, Doaa I. Abdelrahman, Mohammed Alorini, Fatima A. Jaber, Shaimaa Mohamed Abdelfattah Hassan
Twenty-four hours following the last EPO and Myl dosage, final body weights were measured. Ketamine (60 mg/kg i.p.) was used to anesthetize the rats, and blood samples were then taken through retro-orbital punctures, allowing the blood to coagulate. Then, the serum was separated for 15 minutes at 2500 rpm. The serum was utilized for the measurement of liver enzymes. Under anesthesia, the abdomens were opened and the livers were removed. The left lobes from the different groups were frozen in liquid nitrogen, chopped into pieces, and maintained at 80°C to facilitate the creation of tissue homogenates. The homogenized tissues were employed for the measurement of advanced glycation end products (AGE), oxidative stress parameters, pro-inflammatory cytokines, nuclear factor kappa B (NF-κB), and inducible nitric oxide synthase (iNOS). While the right lobe was split into two portions; one was prepared for light microscopic study, while the other was prepared for electron microscopic study.
3-Bromopyruvate elevates ROS and induces hormesis to exert a caloric restriction mimetic effect in young and old rats
Published in Archives of Physiology and Biochemistry, 2023
Jitendra Kumar Arya, Raushan Kumar, Shambhoo Sharan Tripathi, Syed Ibrahim Rizvi
Advanced glycation end products (AGEs) in serum are associated explicitly with the glycation of biomolecules and is a robust biomarker for oxidative stress and aging (Singh et al.2014). AGEs often contribute to the manifestation of accelerated aging, including vascular and microvascular damage, hyperlipidaemia, cataracts, and impaired wound healing (Giacco and Brownlee 2010). In oxidative stress conditions, the production of ROS results in induced glycoxidation reactions, leading to increased endogenous production of reactive aldehydes derivatives which furtherproduce advanced glycating end products (Moldogazieva et al.2019). Our previous report with another glycolytic inhibitor (2-Deoxy glucose), that has the same target, showed a decrease in the AGE level rats after treatment (Saraswat et al.2019). Therefore, we are speculating the same mechanism for the 3-BP-induced decrease in AGE in rats (Figure 4(C)).
Role of advanced glycation end products and insulin resistance in diabetic nephropathy
Published in Archives of Physiology and Biochemistry, 2023
Endoplasmic reticulum (ER) stress is an adaptive response in cells under environmental stress and participate in renal diseases. AGEs dose-dependently decreased mesangial cell viability and induced cell apoptosis. AGEs also induced ER stress signals in a time- and dose-dependent manner. Advanced glycation end products are one of the important factors contributing to the pathogenesis of various inflammatory disorders like obesity, diabetes mellitus along with various diabetic complications, renal disorders, cardiovascular diseases, PCOS and neurodegenerative disorders (Barlovic et al. 2010, Diamanti-Kandarakis et al. 2005, Li et al. 2012, Uribarri et al. 2007). Since AGEs are known to modify the structure of proteins and components of extracellular matrix-like collagen and elastin, they may also lead to misfolding of such proteins. Under such prevailing conditions in a cell, ER stress is generated, which further leads to unfolded protein response (UPR) (Kaufman 2002), which may further lead to apoptosis of a cell. Also, there are various growing evidences that suggest ER stress being one of the ways by which AGEs can induce the alternate way of activating NF-kB and apoptosis in podocytes of the kidneys, endothelial cells and hepatocytes (Sanchez-Niño et al. 2010).