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Nano Delivery of Antiviral Plant Bioactives as Cancer Therapeutics
Published in Devarajan Thangadurai, Saher Islam, Charles Oluwaseun Adetunji, Viral and Antiviral Nanomaterials, 2022
Haripriya Shanmugam, Badma Priya, Manickam Senguttuvan Swetha, Janani Semalaiyappan
Ellagic acid is present in strawberries, raspberries, blackberries, walnuts, and pecans occur in conjugation with glucose moieties. Ellagic acid inhibits the activity of proteases present in the HCV (hepatitis C virus) virus, thereby inhibiting its multiplication. It is studied extensively for its antioxidant and antiproliferative potential. The anti-proliferative nature of ellagic acid has made it a very potent anticancer bioactive; it activates the intrinsic apoptotic pathway and works against several cancers, like carcinoma, cervical, and breast cancers (Reddy et al. 2014).
Chemopreventive Agents
Published in David E. Thurston, Ilona Pysz, Chemistry and Pharmacology of Anticancer Drugs, 2021
Ellagic acid (Figure 12.36) is a phenolic antioxidant found in relatively low amounts in plant tissues. It has been reported to be present in berries such as raspberries (5.8 mg/kg), strawberries (18 mg/kg), and blackberries (88 mg/kg). Ellagic acid has been reported to have chemopreventive properties, with suggested mechanisms including antioxidant, antiproliferative, and pro-apoptotic effects, with evidence of it modulating a number of signaling pathways.
Nanocarriers Systems and Their Application for the Delivery of Different Phytoconstituents
Published in Madhu Gupta, Durgesh Nandini Chauhan, Vikas Sharma, Nagendra Singh Chauhan, Novel Drug Delivery Systems for Phytoconstituents, 2020
Ebru Altuntaş, Gülgün Yener, Burcu Özkan
Ellagic acid is a powerful antioxidant phytochemical with limited applications due to its poor biopharmaceutical characteristics (low permeability and poor solubility). Ellagic acid loaded niosomes were producted from mixtures of Span 60 and Tween 60 for transdermal administration. Researches on skin distribution have shown that ellagic acid-loaded niosomes have a higher skin delivery effect than ellagic acid solutions across human dermis and epidermis (Junyaprasert et al., 2012).
Ellagic acid protects against non-alcoholic fatty liver disease in streptozotocin-diabetic rats by activating AMPK
Published in Pharmaceutical Biology, 2022
Jozaa Z. ALTamimi, Ghedeir M. Alshammari, Nora A. AlFaris, Reham I. Alagal, Dalal H. Aljabryn, Norah A. Albekairi, Mahmoud Ahmad Alkhateeb, Mohammed Abdo Yahya
Ellagic acid is a polyphenol abundant in various fruits, including strawberries, pomegranate, guava, walnuts, almonds, and green tea in the form of hydrolyzable tannins called ellagitannins (Evtyugin et al. 2020). In the intestine, ellagitannins are metabolized to EA, which is metabolized into more absorbable metabolites called urolithin, which may mediate its pharmacological effects (Djedjibegovic et al. 2020). At the clinical and experimental levels, EA possessed several pharmacological health benefits, including acting as an anticarcinogenic, antiviral, anti-inflammatory, antibacterial, antimalarial, antidiabetic, antianxiety, and antiatherogenic molecule (Goswami et al. 2014; Ayhanci et al. 2016; Seo et al. 2016; Polce et al. 2018; Aslan et al. 2020). EA is a potent hepatoprotective, nephroprotective, neuroprotective, and cardioprotective agent due to its well-reported antioxidant, anti-inflammatory, and anti-apoptotic effects (Kannan and Quine 2013; Goswami et al. 2014; Polce et al. 2018, Zhou et al. 2019). Indeed, EA prevented liver damage in several animal models, including, at least, alcohol, carbon tetrachloride (CCl4) cisplatin, cyclosporine, paracetamol, and HFD-induced diabetic rats.
The impact of ellagic acid on some apoptotic gene expressions: a new perspective for the regulation of pancreatic Nrf-2/NF-κB and Akt/VEGF signaling in CCl4-induced pancreas damage in rats
Published in Immunopharmacology and Immunotoxicology, 2021
Abdullah Aslan, Seda Beyaz, Ozlem Gok, Muhammed Ismail Can, Fazilet Erman, Orhan Erman
Antioxidants play a major role in protection toward these factors [8–10]. With the latest studies, ellagic acid (EA) has been found to have strong anti-inflammatory, antioxidative, and anticancer properties. It has been defined as an active compound responsible for the antioxidant properties, a plant-derived polyphenol found in a large diversity of nuts and fruits, such as strawberries, walnuts, grapes, raspberries, and black currants. The effects of EA on PSC activation and cell functions have been evaluated and it has been shown that it inhibits the activation of basic cell functions and PSCs [11,12]. It has been found that EA has antidiabetic activity through its effect on β-pancreas cells that stimulates insulin secretion and decreases glucose sensitivity, especially due to its strong antioxidant activity [13]. In particular, EA administration has been shown to improve insulin resistance [14].
Comparison of the Protective Effect of Salvia officinalis and Rosmarinus officinalis Infusions Against Hepatic Damage Induced by Hypotermic-Ischemia in Wistar Rats
Published in Nutrition and Cancer, 2020
Sana Bahri, Ridha Ben Ali, Raed Abdennabi, Dorra Ben Said, Mona Mlika, Mohamed Kacem Ben Fradj, Michelle Véronique El May, Saloua Ben Khamsa Jameleddine
These findings can be explained following the analysis by HPLC, which showed the presence of gallic acid, vanillic acid, ellagic acid, and ferullic acid in R. officinalis L. at a higher level than that in S. officinalis L. (84.03 vs. 57.43 mg/L; 1272.63 vs. 332.00 mg/L; 1719.18 vs. 21.13 mg/L; 219.01 vs. 30.35 mg/:L, respectively). Gallic acid was found to play an anticarcinogenic, antimicrobial, antimutagenic, antiangiogenic, and anti-inflammatory roles (23). Vanilic acid was described to have an antioxidant activity by reducing cisplatin induced nephrotoxicity in rats (24). Ferulic acid was also described to contribute to the suppression of melanoma growth and angiogenesis (25). Ellagic acid has been reported to have anti-inflammatory, antitumor, and hepatoprotective effects (26) and to play an antioxidant activity (27). Together, all these findings suggest that these compounds found in abundance in R. officinalis L. than in S. officinalis L. infusions can probably converge to play a hepatoprotective role against hypotermic-ischemia inducing liver lesion.