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Clinical Considerations in Radiotracer Biodistribution Studies
Published in Lelio G. Colombetti, Biological Transport of Radiotracers, 2020
The administration of 1.25 mg of vitamin D3 intravenously in rats caused a significant decrease in the uptake of 99mTc PPi and 99mTcDP by bone. Administration of 1.25 mg of dihydrotachysterol by stomach tube caused a significant increase in the ratio: uptake of 99mTc PPi by myocardial infarct/uptake by bone.43
Premature Aging
Published in Nate F. Cardarelli, The Thymus in Health and Senescence, 2019
The presence of an animal model of accelerated aging would greatly facilitate research in the areas of gerontology and geriatrics. One can chemically induce certain conditions found in the aged in laboratory animals, such as administering dihydrotachysterol to rodents.191 However, the metabolic changes observed only apply to one aspect of aging, and do not correlate with the human condition.
Skin
Published in Pritam S. Sahota, James A. Popp, Jerry F. Hardisty, Chirukandath Gopinath, Page R. Bouchard, Toxicologic Pathology, 2018
Zbigniew W. Wojcinski, Lydia Andrews-Jones, Daher Ibrahim Aibo, Rie Kikkawa, Robert Dunstan
Mineralization may occur secondary to inflammation in the subcutis or may be associated with high dietary levels of calcium. Dihydrotachysterol causes mineralization of subcutaneous tissues by a mechanism involving mobilization of calcium stores.
Proteomics based drug repositioning applied to improve in vitro fertilization implantation: an artificial intelligence model
Published in Systems Biology in Reproductive Medicine, 2021
Roberto Matorras, Raquel Valls, Mikel Azkargorta, Jorge Burgos, Aintzane Rabanal, Felix Elortza, Jose Manuel Mas, Teresa Sardon
Among the drug candidates in Table 3, three vitamin D-related compounds, doxercalciferol, calcidiol, and dihydrotachysterol, were identified. The decidua produces calcitriol in response to IL-1B secreted by the blastocyst. It may help support implantation by attenuating decidual T-cell function (Barrera et al. 2015; Thangamani et al. 2015). Decidual NK cells treated with calcitriol show decreased cytokine synthesis, such as IL-6 and TNFα, which are linked to pregnancy failure (Tamblyn et al. 2015). Additionally, vitamin D may play an important autocrine role through its regulation of the transcription of genes such as HOXA10, critical for EI and placentation (Evans et al. 2004). Several studies have shown worse IVF outcomes in women with deficient vitamin D levels (Chu et al. 2018; Iliuta et al. 2020), and vitamin D supplementation is recommended in IVF deficient and insufficient women (Chu et al. 2018; Iliuta et al. 2020).
Bone mineral density in primary care patients related to serum calcium concentrations: a longitudinal cohort study from Sweden
Published in Scandinavian Journal of Primary Health Care, 2018
Sofia Dalemo, Robert Eggertsen, Per Hjerpe, Erik G. Almqvist, Kristina Bengtsson Boström
The characteristics of the study subjects are presented in Table 1. In the group with baseline elevated calcium concentrations, the median value at baseline was 2.60 (2.56–2.78, 10th and 90th percentile), and 2.45 mmol/L (2.27–2.58, 10th and 90th percentile) at follow-up. Body constitution (body height and weight) did not differ between the groups with elevated and normal calcium concentrations at baseline. Furthermore, the only significant difference between two groups Table 2 was that the total group and women with baseline elevated calcium concentrations had been using oral corticosteroids for long periods compared with those with normal calcium concentrations. Thus there no significant differences between the groups with elevated and normal calcium concentrations at baseline regarding previous fractures (distal forearm, humerus, proximal femur and vertebra), family history of fractured hip, age at menopause, smoking habits or low BMI, and medication with multivitamins, oestrogens or dihydrotachysterol (data not shown).
Calciphylaxis-as a drug induced adverse event
Published in Expert Opinion on Drug Safety, 2019
Ignacio Portales-Castillo, Daniela Kroshinsky, Cindy K. Malhotra, Roberta Culber-Costley, Mario Gennaro Cozzolino, Shelly Karparis, Charles L. Halasz, Jeremy Goverman, Harold J. Manley, Rajeev Malhotra, Sagar U. Nigwekar
In 1961 Selye, Gabbiani and Strebel published experiments describing extensive cutaneous calcification in rats after exposure to certain agents and introduced the term ‘calciphylaxis’. They described calciphylaxis as a form of hypersensitivity from the exposure to a ‘calcifier’ (dihydrotachysterol, vitamin D2, vitamin D3, parathyroid hormone [PTH]) and then to a ‘challenger’ (metallic salts such as iron, aluminum, egg albumin, or trauma) [7,8]. In the next few years reports of cutaneous calcifications in patients with advanced renal failure were published [9,10].