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Herbs with Antidepressant Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
There are no studies of the use of Apium graveolens in the treatment of MDD in human subjects. 3-n-Butylphthalide, found in Apium graveolens, has shown remarkable effects in the treatment of stroke, and has neurochemical effects that would also be expected to improve MDD. There have been no tests of 3-n-Butylphthalide in the treatment of MDD. Doses of 200 mg 3-n-Butylphthalide three times daily have been safely and effectively used in patients with vascular cognitive impairment without dementia, stroke, or MDD.20
Effects of butylphthalide injection on treatment of transient ischemic attack as shown by diffusion-weighted magnetic resonance imaging abnormality
Published in International Journal of Neuroscience, 2020
Chenhao Zhang, Yanjing Zang, Qin Song, Weidong Zhao, Hongxuan Li, Lei Hu, Qing Zhang, Fang Gu, Chunliang Zhang
Butylphthalide injection in is a new type of brain protective drug, which is a clear pale yellow oil-like liquid at room temperature. The chemical name of butylphthalide is dl-3-butyl-1 (3)-isobenzofuranone with molecular formula of C12H14O2 and molecular weight of 190.24 g/mol, that was extracted from seeds of celery Apium graveolens Linn. Previous studies [13,14] have shown that butylphthalide can reverse injury of ischemic neurons through multiple targets, and promote the collateral circulation to establish and protect vascular endothelial function. Several studies [15–20] have shown that dl-3n-butylphthalide can directly pass through the blood brain barrier, which has been used to treat cerebral ischemia and dementia. dl-3n-butylphthalide can promote the increase in the number of capillaries, restore microcirculation in the ischemic region, protect the mitochondria and improve the brain energy metabolism after cerebral infarction. dl-3n-butylphthalide can also improve cerebral blood flow in the ischemic area and reduce the infarction area. Moreover, dl-3n-butylphthalide can inhibit the release of glutamic acid, reduced calcium concentration in cells, decrease generation of free radicals, exert antioxidant activity and decrease cell apoptosis after cerebral ischemia. Therefore, this study examined the effect of butylphthalide injection for treating patients with TIA and positive DWI findings. We investigated the effectiveness and safety of butylphthalide injection in preventing and treating lesions that progressed to cerebral infarction. We also examined the association of the effect of butylphthalide injection in these patients and ABCD2 scores.