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Apiaceae Plants Growing in the East
Published in Mahendra Rai, Shandesh Bhattarai, Chistiane M. Feitosa, Ethnopharmacology of Wild Plants, 2021
Sherweit El-Ahmady, Nehal Ibrahim, Nermeen Farag, Sara Gabr
A. graveolens is characterized by a peculiar fragrance attributed to its volatile constituents. Celery leaves display the highest yield of volatile oil which is mainly composed of α- and β-pinene, myrcene, limonene, 1-dodecanol, 9-octadecen-12-ynoic acid methyl ester and tetradecence-1-ol acetate (Malhotra 2012, Nagella et al. 2012). On the other hand, the fruit volatile oil contains mainly limonene, phthalides as 3-n-butyl phthalide, sedanenolide and sedanolide in addition to α- and β-selinene, apiol, sedanonic anhydride and caryophyllene (Hassanen et al. 2015). The fruit oil is more enriched in sesquiterpenoids than leaf oil, while the leaf oil contains more monoterpenoids (Sowbhagya 2014). Phthalides are responsible for most of the medicinal effects of celery including anti-inflammatory, hypotensive and insecticidal activities (Sowbhagya 2014).
Catalog of Herbs
Published in James A. Duke, Handbook of Medicinal Herbs, 2018
On steam distillation French seed yield 1.9 to 2.4% oil; Indian seed yield 2.14 to 2.50%. The essential oil contains the glucoside apiin. Celery seed oil contains ca. 60% limonene, 10 to 15% selenine, 1 to 3% sesquiterpene alcohols, sedanolide, sedanonic anhydride a phenol (perhaps guaiacol), and palmitic acid.29 Seeds also contain myristicic acid, hydroxy-methoxypsoralen, and umbelliferone. Diuresis may be due to the presence of glycolic acid Stalks may yield the photodynamically active principle bergapten. Per 100 g, the leaf is reported to contain 21 calories, 92.8 g HX), 1.4 g protein, 0.3 g fat, 4.2 total carbohydrate, 1.0 g fiber, 1.3 g ash, 62 mg Ca, 37 mg P, 2 5 mg Fe, 96 mg Na, 326 mg K, 1,040 μg beta-carotene equivalent, 0.06 mg thiamine, 0.07 mg riboflavin, 0.4 mg niacin, and 20 mg ascorbic acid. Garg et al.88 report 6 coumarins in the seeds, seselin, isoimperatorin, osthenol. bergapten, isopimpinellin, and the novel apigravin. Per 100 g, celery seed is reported to contain 392 calories (1,641 kJ), 6.6 g H2O, 18.1 g protein, 25.3 g fat, 41.4 g total carbohydrate, 11.8 g fiber, 9.3 g ash, 1,767 mg Ca, 547 mg P, 45 mg Fe, 440 mg Mg, 160 mg Na, 1,400 mg K, 6.9 mg Zn, 52 IU vitamin A, and 17.1 mg ascorbic acid. There are 60 mg phytosterol.89
Abies Spectabilis (D. Don) G. Don (Syn. A. Webbiana Lindl.) Family: Coniferae
Published in L.D. Kapoor, Handbook of Ayurvedic Medicinal Plants, 2017
The celery fruits yield 2 to 3% of pale-yellow volatile oil with a persistent odor, characteristic of the plant. The fruits also yield 17% of a fatty oil called oil of celery. Chemical constituents of the essential oil are d-limonene, d-selinene, sesquiterpene alcohols, sedanolide, and sedanomic acid anhydride. Chemical examination of the seeds showed the presence of anthoxanthins which consisted almost completely of glycosides which have been separated into two entities called graveobioside A and graveobioside B. Both of them yielded apiose and glucose on hydrolysis, but the aglycone of graveobioside A was found to be luteolin and that of graveobioside B, chrysoeriol. It was seen that glycosides are apiose glucosides.102
Tanshinone I induces cell apoptosis by reactive oxygen species-mediated endoplasmic reticulum stress and by suppressing p53/DRAM-mediated autophagy in human hepatocellular carcinoma
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2020
Emerging evidence has shown that autophagy may serve as a potential therapeutic target for cancer therapy, and autophagy exerts a contradictory effect in different cancer cell types. Recently, it has been reported that TA IIA induces autophagic cell death in KBM-5 and SCC-9 cells [34,35]. In A375 cells, TA IIA inhibits the proliferation of A375 cells by activating the autophagy pathway [36]. However, Lee et al. revealed that TA I induces protective autophagy in malignant pleural mesothelioma cells [37]. Jing et al. also revealed that TA I induces pro-survival autophagy in gastric cancers [4]. Our results showed that TA I significantly decreased the expression of autophagy-related proteins LC3B-II and beclin-1 in HepG2 and Huh7 cells. Furthermore, 3-MA and TA I significantly increased cell growth inhibition compared with TA I treatment alone in HepG2 and Huh7 cells. Additionally, Cui et al. reported that p53/DRAM-mediated autophagy contributes to radiation-induced death in MCF-7 breast cancer cells [38]. Hsieh et al. reported that sedanolide promotes autophagy via the p53/DRAM signaling pathway in human liver cancer J5 cells [39]. Wei et al. also demonstrated that XingNaoJing inhibits autophagy by suppressing the p53/DRAM signaling pathway in PC12 cells [12]. Interestingly, our results demonstrated that TA I decreased p53 and DRAM expression in HepG2 and Huh7 cells. These data indicated that TA I induced cell apoptosis by repressing p53/DRAM-mediated autophagy in HepG2 and Huh7 cells.