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Herbal Drug Discovery Against Inflammation: From Traditional Wisdom to Modern Therapeutics
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
Shalini Dixit, Karuna Shanker, Madhumita Srivastava, Priyanka Maurya, Nupur Srivastava, Jyotshna, Dnyaneshwar U. Bawankule
Pentacyclic triterpenes (PTs) as aglycones of saponins have been used as anti-inflammatory remedies in folk medicine (Safayhi and Sailer, 1997). Betula alba, B. pendula, B. pubescent, and B. platyphylla containing betulin as an active biological constituent. Studies reported on the activity of methanolic extract from the rhizomes of N. nucifera, as well as betulin and betulinic acid, revealed a marked inhibition of the carrageenan and serotonin-induced rat paw edema. The fruit juice of Ecballium elaterium L.A Cucurbitacin. (Family-Cucurbitaceae) used as Turkish folk medicine for the treatment of sinusitis has been investigated for its anti-inflammatory activity (Perez, 2001). Plant sterols and n-3 polyunsaturated fatty acids (PUFA) reduces systemic inflammation as well as are cardioprotective in hyperlipidemic individuals (Micallef and Garga, 2009). Oleanolic acid 3-glucoside Isolated from Randia dumetorum Lam. (Rubiaceae) seeds showed significant anti-arthritic activity in the exudative and proliferative phases of inflammation in rats (Perez, 2001). Cyperus rotundus (Cyperaceae) and Bryophyllum pinnatum (Crassulaceae) contain ß-sitosterol which shows anti-inflammatory and antipyretic activities which have been studied on carrageenan-induced edema, cotton pellet implantation, and Brewer´s yeast-induced pyrexia in rats. ß-Sitosterol was found to possess potent anti-inflammatory activity against both tests, similar to hydrocortisone and oxyphenbutazone (Perez, 2001).
Survey of Indigenous Knowledge of Medicinal Plants in India
Published in Megh R. Goyal, Preeti Birwal, Santosh K. Mishra, Phytochemicals and Medicinal Plants in Food Design, 2022
Acharaya Balkrishna, Nishant Gupta, Deepak K. Gond, Ishwar P. Sharma, Rachana Bhandari, Vedpriya Arya
In some previous studies performed at Bhiwani district [3, 4], Bryophyllum pinnatum and Crateva magna were reported useful in stone-related problems. Scoparia dulcis was reported from different study areas [8]. Similar ethnobotanical and medicinal practices have previously been studied in different localities of Haryana, such as Jhajjar district [18],Central Haryana [4, 7],Gurugram district [21],Hisar district [40],Karnal district [26],Mahendergarh district [30, 31, 32],Plains of Yamuna Nagar district [22],Whole Haryana [3, 12].
The Role of Herbal Medicines in Female Genital Infections
Published in Megh R. Goyal, Hafiz Ansar Rasul Suleria, Ramasamy Harikrishnan, The Role of Phytoconstitutents in Health Care, 2020
Many plant species are available for the treatment of vaginal infections such as [53, 59, 83]: Bridelia cathartica subsp cathartica;Bryophyllum pinnatum;Cladostemon kirkii;Clematis brachiata;Euphorbia hypericifolia;Erianthemum dregei;Euphorbia hypericifolia;Hypoxis hemerocallidia;Ipomoea batatas;Krauseola mosambicina;Mimusops caffra;Opuntia stricta;Origanum vulgare;Pyrenacantha kaurabassana;Ranunculus multifidus;Sarcophyte sanguinea subsp. sanguinea;Senecio serratuloides.
UPLC-PDA-ESI-QTOF-MS/MS fingerprint of purified flavonoid enriched fraction of Bryophyllum pinnatum; antioxidant properties, anticholinesterase activity and in silico studies
Published in Pharmaceutical Biology, 2021
Joyce Oloaigbe Ogidigo, Chioma Assumpta Anosike, Parker Elijah Joshua, Collins U. Ibeji, Daniel Emmanuel Ekpo, Bennett C. Nwanguma, Okwesili Fred Chiletugo Nwodo
Bryophyllum pinnatum (Lam.) Oken (Crassulaceae) is a succulent perennial herb commonly known as ‘miracle plant’ and in Nigeria locally known as ‘Oda opue’ in Igbo and ‘Abamoda’ in Yoruba. It is widely distributed in tropical Africa, India, China, Australia, and South America (Afzal et al. 2013). Bryophyllum pinnatum flourishes throughout parts of Southern Nigeria and is commonly used in folk medicine for the treatment of many ailments (Afzal et al. 2013; Chibli et al. 2014). Several bioactive compounds including, phenolics, alkaloids, flavonoids, triterpenes, glycosides, steroids, bufadienolides, cardenolides, and organic acids, have been identified and documented in B. pinnatum (Fernandes et al. 2019). Bryophyllum pinnatum plant extracts are reported to possess several pharmacological activities including antimicrobial (Abubakar et al. 2014), neuropharmacological (Salahdeen and Yemitan 2006), anti-inflammatory and analgesic (Fürer et al. 2013), muscle relaxant and sedative (Plangger et al. 2006), gastroprotective (Afzal et al. 2013) and antioxidant (Sharma et al. 2014).
Neuroprotective effect of Bryophyllum pinnatum flavonoids against aluminum chloride-induced neurotoxicity in rats
Published in Toxicology Mechanisms and Methods, 2022
Joyce Oloaigbe Ogidigo, Chioma Assumpta Anosike, Parker Elijah Joshua, Collins U. Ibeji, Bennett C. Nwanguma, Okwesili Fred Chiletugo Nwodo
Fresh leaves of Bryophyllum pinnatum was collected from the Nsukka area, Enugu State, Nigeria. The leaves were identified and authenticated by a Botanist, Dr Grace Ugabe, at the Herbarium of the National Institute for Pharmaceutical Research and Development Abuja Nigeria, with reference number: NIPRD/H/6855. B. pinnatum leaves were rinsed with water, cut into small pieces, air-dried, and pulverized using a mechanical blender. The pulverized sample was kept in a dry airtight container until extraction.