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Curative Properties of Chamomile in Gastrointestinal Disorders
Published in Megh R. Goyal, Preeti Birwal, Durgesh Nandini Chauhan, Herbs, Spices, and Medicinal Plants for Human Gastrointestinal Disorders, 2023
Bisabolol has been reported to decrease the quantity of proteolytic enzyme “pepsin” by the stomach except for any alterations in the amount of stomach acid, as a result of which it was prescribed for the treatment of stomach and upper intestinal disorders.45
Chemistry of Essential Oils
Published in K. Hüsnü Can Başer, Gerhard Buchbauer, Handbook of Essential Oils, 2020
α-Bisabolol (115) is the simplest of the cyclic sesquiterpenoid alcohols. If farnesol is the sesquiterpenoid equivalent of geraniol and nerolidol of linalool, then α-bisabolol is the equivalent of α-terpineol. It has two chiral centers and therefore exists in four stereoisomeric forms, all of which occur in nature. The richest natural source is Myoporum crassifolium Forst., a shrub from New Caledonia, but α-bisabolol can be found in many other species including chamomile, lavender, and rosemary. It has a faint floral odor and anti-inflammatory properties and is responsible, at least in part, for the related medicinal properties of chamomile oil.
Catalog of Herbs
Published in James A. Duke, Handbook of Medicinal Herbs, 2018
Flowerheads contain an aromatic bitter principle (anthemic acid), regarded as a mild tonic, but may be emetic in large doses. In Latin America, “tea” made from Matricaria is taken as an after dinner beverage. Oil of camomile is used in cordials, perfumes, and shampoos. Both negative and positive bactericidal tests are reported on Mycobacterium tuberculosis, Salmonella typhimurium, and Staphylococcus aureus8 Azulene has an antiphlogistic action.3 Chamillin is said to be the spasmolytic agent, perhaps the same as apigenine.3 The oil has candicidal properties as well.29 Chamazulen is said to possess anodyne, antiinflammatory, antiseptic, antispasmodic, and vulnerary properties. Alpha-bisabolol has antiinflammatory, antimicrobial, and antipeptic activities. Some of the cylic ethers in chamomile are antian-aphylactic, antiinflammatory, antimicrobial, and antispasmodic. Umbelliferone is fungistatic. Camomile tea itself is hypnotic.2933 Extracts are used in bath preparations, hair dyes, mouth washes, shampoos, and sunburn preparations. Oils are used to impart fragrance to creams, detergents, lotions, perfumes, and soaps, and as a flavoring in beverages, baked goods, candies, frozen dairy desserts, gelatins, liqueurs (benedictine, bitters, vermouths), and pudding, with average food use usually below 0.002%.29
The effect of chamomile extract obtained in supercritical carbon dioxide conditions on physicochemical and usable properties of pharmaceutical ointments
Published in Pharmaceutical Development and Technology, 2018
Emilia Klimaszewska, Artur Seweryn, Anna Małysa, Małgorzata Zięba, Joanna Lipińska
Plant ingredients are commonly used in the pharmaceutical (Eshun & He 2004, p. 91; Srivastava et al. 2010, p. 895; Singh et al. 2011, p. 82), cosmetic (Kole et al. 2005, p. 315; Khan & Abourashed 2010, p. 657; Herman et al. 2013, p. 232; Sikora et al. 2015, p. 574; Klimaszewska et al. 2016, p. 1000), household chemicals (Gambogi et al. 2006, p. 171; Sikora et al. 2015, p. 574; Wasilewski & Seweryn 2016, p. 778; Wasilewski et al. 2016a, p. 368; 2016b, p. 114; 2016c, p. 1315) and food industries (Eshun & He 2004, p. 91; Khan & Abourashed 2010, p. 657) due to their natural abundance. One example is wild chamomile which is known to have a wide spectrum of pharmacological and therapeutic activities (Singh et al. 2011, p. 82). Among other valuable ingredients, chamomile extracts contain alpha-bisabolol (Avonto et al. 2013, p. 1848). The role of the compound in pharmacological and physiological processes is summarized in studies by Kamatou and Viljoen (2010, p. 1). Alpha-bisabolol exhibits anti-inflammatory, analgesic, antibacterial and anticancer effects. In addition, high levels of alpha-bisabolol in chamomile are responsible for increasing transcutaneous drug penetration. Safayhi et al. (1994, p. 410) showed chamazulene to be another important ingredient of wild chamomile. Chamazulene may contribute to the anti-inflammatory effect induced by chamomile by inhibiting the synthesis of leukotrienes and producing additional antioxidative activity. Other valuable active ingredients found in chamomile extracts include polyphenols, polyunsaturated fatty acids (linoleic acid) and mineral salts (Scalia et al. 1999, p. 549; Cushnie & Lamb 2005, p. 343; Orav et al. 2010, p. 48).
Effectiveness of Matricaria chamomilla (chamomile) extract on pain control of cyclic mastalgia: a double-blind randomised controlled trial
Published in Journal of Obstetrics and Gynaecology, 2018
N. Saghafi, H. Rhkhshandeh, N. Pourmoghadam, L. Pourali, M. Ghazanfarpour, A. Behrooznia, F. Vafisani
Chamomile, scientifically known as Matricaria Chamomilla, belongs to the family of composite plants, which are indigenous of Mediterranean region. This medicinal plant is made of various constituents such as Chamazulene with anti-inflammatory and antioxidant effects, apigenin with anti-inflammatory, analgesic and antineoplastic effect, flavonoid with anti-inflammatory and anti-anxiety effect, and finally alpha bisabolol with anti-inflammatory and digestive effect (Sharifi et al. 2014).
Pharmaceutical agents for treatment of leishmaniasis: a patent landscape
Published in Expert Opinion on Therapeutic Patents, 2020
Yasmim Maria Barbosa Gomes de Carvalho, Saravanan Shanmugam, Mayrton Santos Batista, Mairim Russo Serafini, Adriano Antunes De Souza Araújo, Lucindo José Quintans Júnior
According to inventors, (-)-α-bisabolol concentration in the composition ranges from 0.01% to 3.0% w/w (i.e. in weight, by weight of the total composition), which present effects: antileishmanial; anti-inflammation and/or local skin necrosis; limitation of dissemination of the parasite to other tissues; activation of the wound healing process.