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The Twentieth Century and Beyond
Published in Scott M. Jackson, Skin Disease and the History of Dermatology, 2023
Today, dermatologists spend a considerable amount of time in each office visit counseling patients on the proper way to care for their largest organ. There are countless skin care products available; some have more evidence behind their promises than others. A simple and evidence-based skin care regimen for the face involves cleansing the face with a gentle cleanser twice daily, the morning application of a moisturizer with a sun-protective factor (SPF 15 or higher) along with an antioxidant lotion that contains Vitamin C, and the nighttime application of a moisturizer along with a retinoid cream. Vitamin C binds the sun-generated free radicals and prevents aging of our skin, while retinoids repair the actual damage from the sun. The earlier in a person's life this routine is started, the more likely a person will appreciate the benefits of it later in life. Other evidence-based products are fluorouracil cream, hydroquinone, and alpha and beta hydroxy acids. The secret to finding the right skin care products, and not modern-day snake oil, is to research the product's ingredients.
Evaluating Performance Benefits of Conditioning Formulations on Human Skin
Published in Randy Schueller, Perry Romanowski, Conditioning Agents for Hair and Skin, 2020
Ronald L. Rizer, Monya L. Sigler, David L. Miller
Individuals should be excluded from a study who have a recent history of using a cosmetic that contains the same active ingredient as the product being tested. Examples include alpha-hydroxy acids, beta-hydroxy acids, and retinoids.
Future and Novel Unexplored Indications of Retinoids
Published in Ayse Serap Karadag, Berna Aksoy, Lawrence Charles Parish, Retinoids in Dermatology, 2019
The irritant potential of presently used topical retinoids can lead to post-inflammatory hyperpigmentation, especially in skin of color. A novel combination of a bioengineered molecule (alpha hydroxy acid [AHA] and retinoid conjugate [RC], or AHA-RC) has been tested in vivo (5). This delivers both lactic acid (AHA) and RC. A combination product containing 0.1% AHA-RC, 2% salicylic acid (a beta hydroxy acid–BHA), and 10.4% L-lactic acid has also been evaluated, where it is proposed that the combination would selectively ensure the best properties of the components, i.e., RC-induced normalization of cellular differentiation, AHA-induced exfoliation in hydrophilic areas, and BHA-induced exfoliation in lipophilic areas (5).
Study of biosurfactant extract from corn steep water as a potential ingredient in antiacne formulations
Published in Journal of Dermatological Treatment, 2022
Lorena Rodríguez-López, Myriam Rincón-Fontán, Xanel Vecino, José M. Cruz, Ana B. Moldes
Many active principles with antimicrobial activity are used against C. acnes. Some examples could be derivatives from vitamin A or zinc salts, among others. For instance, zinc salts are known by their anti-inflammatory effect, as well as their antimicrobial activity (3,4,17). Bae and Park (18) have also reported the synergetic effect of ZnO and citric acid against C. acnes. Moreover, it is common to see salicylic acid in formulations against acne vulgaris. Salicylic acid, a beta hydroxy acid, acts not only as antimicrobial agent, but also has keratolytic action, which helps to unclog pores and reduce the acne (19–22).
Is maintenance treatment in adult acne important? Benefits from maintenance therapy with adapalene, and low doses of alpha and beta hydroxy acids
Published in Journal of Dermatological Treatment, 2019
Ewa Chlebus, Monika Serafin, Marcin Chlebus
Another factor worth highlighting is that many female patients over the age of 25 years, in addition to skin treatment and improvement in its appearance (a reduction in acne lesions) also expect assistance in selecting skin care products with moisturizing and anti-aging properties which, at the same time, do not interfere with their therapy. The substances contained in considered dermocosmetics (alpha and beta hydroxy acids) are compounds with recognized exfoliating, skin smoothing and brightening properties. In addition to acne elimination, they provide good skin appearance.